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This thesis concerns the legal consequences and the economic effects of the use of a damages clause (avtalsvite). Starting from a rather routinely picture in the legal literature, the thesis seeks to establish a more sophisticated application of the clause, in order to maximize the parties total utility.Thanks to their long-standing use, there is a generally accepted picture of what damages clauseThis thesis concerns the legal consequences and the economic effects of the use of a damages clause (avtalsvite). Starting from a rather routinely picture in the legal literature, the thesis seeks to establish a more sophisticated application of the clause, in order to maximize the parties total utility.Thanks to their long-standing use, there is a generally accepted picture of what damages clause

OBJECTIVE: HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explored. The aim of this population-based cohort study was to assess the association

Populations of Dactylorhiza incarnata (early marsh orchids) with spotted leaves appear in widely separate parts of Europe including Scandinavia and the Baltic area, The Alps, and Britain and Ireland. Forms with spotted leaves have often been segregated as a separate subspecies, D. incarnata subsp. cruenta. Although previous studies have indicated that the taxon is heterogeneous, it is not known hoPopulations of Dactylorhiza incarnata (early marsh orchids) with spotted leaves appear in widely separate parts of Europe including Scandinavia and the Baltic area, the Alps, and Britain and Ireland. Forms with spotted leaves have often been segregated as a separate subspecies, D. incarnata subsp. cruenta. Although previous studies have indicated that the taxon is heterogeneous, it is not known ho

During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we dem

Background : Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development. Objective : This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations. Design : In the Malmö Diet and Cancer Study, diet

Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.Design: Prospective cohort study.Setting: The M

Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a raredisease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment.This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-basedregistry data, (II) to evaluate tolerability and efficacy of lenalidomiMantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-based registry data, (II) to evaluate tolerability and efficacy of lenalid

Popular Abstract in English From the pure technological perspective (leaving the business aside), the design of electronic devices, such as mobile phones, is an extremely complex process often involving a large number of disciplines, from mastering complicated mathematical models to proficiency of physical and electrical properties of specific materials involved in the manufacturing. In order to oThe methodology behind this work has been to use the concept of algorithm-hardware co-design to achieve efficient solutions related to the digital front-end in mobile receivers. It has been shown that, by looking at algorithms and hardware architectures together, more efficient solutions can be found; i.e., efficient with respect to some design measure. In this thesis the main focus have been plac

Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.

The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study"

Popular Abstract in Swedish Under tidigmodern tid utvecklades på kronans gods i Danmark en interaktion mellan bönderna och överheten som byggde på intressegemenskap och en tvingande omsorgspraktik. Den nödvändiga samlevnaden mellan styrande och styrda utmärktes av interdependens och intersubjektiva lösningar på konflikter. Detta system framväxte som en nödvändighet för att minska effekterna av bönIn the early-modern period, Danish peasants living on crown estates across the country found a profitable way of interacting with the crown and its representatives. The necessary co-existence of rulers and ruled was marked by inter-dependence, solidarity of interest, and inter-subjective resolution of conflict. The system served to lessen the consequences of natural disasters that otherwise affect

We studied leukemic stem cells (LSCs) in a Smad4(-/-) mouse model of acute myelogenous leukemia (AML) induced either by the HOXA9 gene or by the fusion oncogene NUP98-HOXA9. While HOXA9-SMAD4 complexes accumulate in the cytoplasm of normal hematopoietic stem- and progenitor cells (HSPCs) transduced with these oncogenes, there is no cytoplasmic accumulation of HOXA9 in Smad4(-/-) HSPCs and as a con

The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) c

The risk of distant recurrence in breast cancer patients is difficult to assess with current clinical and histopathological parameters, and no validated serum biomarkers currently exist. Using a recently developed recombinant antibody microarray platform containing 135 antibodies against 65 mainly immunoregulatory proteins, we screened 240 sera from 64 patients with primary breast cancer. This uni

Popular Abstract in English Imagine a solar powered flash light. Each photon absorbed by the flash light’s solar cell creates electric energy and the flash light’s light source converts the electrical energy again into photons. The purpose of such a device may be questionable, because you would be surprised if it would create more light than what it absorbs. However, under certain conditions it isIn this thesis the luminescence properties of highly doped semiconductors are studied with focus on degenerately n-doped InP. It is demonstrated how photoluminescence measurements on degenerately doped semiconductors allow an estimation of the doping concentration without need for electrical contacts. The degenerate doping can furthermore reveal the conduction band structure for energies higher th

Globally, malignant melanoma shows a steady increase in the incidence among cancer diseases. Malignant melanoma represents a cancer type where currently no biomarker or diagnostics is available to identify disease stage, progression of disease or personalized medicine treatment. The aim of this study was to assess the tissue expression of alpha-synuclein, a protein implicated in several disease pr

Popular AbstractAvhandlingen är en pedagogikhistorisk kvinnobiografi. Min empiri bygger främst på ett biografiskt material bestående av litteratur av och om Honorine Hermelin Grønbech, samt brev från och till henne, radio- och TV-program jämte material kring skolan, protokoll, föreläsningsanteckningar samt samtal med tidsvittnen. Mot bakgrund av en pedagogy-historical and a women’s historical contThe aim of the dissertation is to analyse, in the light of the history of education and of women, ”biographical sections” of the life and work of the Swedish educationalist Honorine Hermelin Grønbech (1886-1977). The focus is on adult education, and in particular female civic education, which set out to encourage Swedish women to exercise their newly won rights of citizenship (1921). The publicat

We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative