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Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demo

Researcher Contact details Email: petter [dot] pilesjo [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Service point: 16 WebpagePetter Pilesjös profile in Lund University research portalOther affiliations Researcher Centre for Advanced Middle Eastern Studies (CMES) Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in a Changin

https://www.cmes.lu.se/petter-pilesjo - 2026-05-08

Tracking techniques are vital for the understanding of the biology and ecology of organisms. While such techniques have provided important information on the movement and migration of large animals, such as mammals and birds, scientific advances in understanding the individual behaviour and interactions of small (mm-scale) organisms have been hampered by constraints, such as the sizes of existing

Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potent

Mediterranean diet has been suggested to explain why coronary heart disease mortality is lower in southern than northern Europe. Dietary habits can be revealed by isotope ratio mass spectrometry (IRMS) measurement of carbon (δ(13)C) and nitrogen (δ(15)N) in biological tissues. To study if diet is associated with human plaque stability, atherosclerotic plaques from carotid endarterectomy on 56 pati

Popular Abstract in English Large market-driven software companies face new challenges in requirements engineering and management that emerged due to their recent extensive growth. At the same time, the pressure generated by competitors’ and users’ expectations demands being more competitive, creative and flexible to more quickly respond to a rapidly changing market situation. In the pursuit of stLarge market-driven software companies face new challenges in requirements engineering and management that emerged due to their recent extensive growth. At the same time, the pressure generated by competitors’ and users’ expectations demands being more competitive, creative and flexible to more quickly respond to a rapidly changing market situation. In the pursuit of staying competitive in this co

BACKGROUND: Viral gene therapy of malignant brain tumors has been restricted by the limited vector distribution within the tumors. Multipotent mesenchymal stromal cells (MSCs) and other precursor cells have shown tropism for gliomas, and these cells are currently being explored as potential vehicles for gene delivery in glioma gene therapy. OBJECTIVE: To investigate MSC migration in detail after i

Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M

Appropriate regulation of hematopoietic stem cell (HSC) numbers and function is a requisite for life-long blood cell replenishment. Knowledge of factors that regulate HSC activity is derived largely from murine model systems, with serial transplantation often considered a "gold standard" to assess longevity and self-renewal of HSCs. In the literature, we noted inconsistencies in how serial transpl

Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM

Studies on fibre intake and incident colorectal cancer (CRC) indicate inverse associations. Differences by tumour stage have not been examined. We examined associations between fibre intake and its sources, and incidental CRC. Separate analyses were carried out on the basis of sex, tumour location and the Tumour, Node, Metastasis (TNM) classification. The Malmö Diet and Cancer Study is a populatio

Background:Observational studies have mostly found no association between self-reported whole-grain (WG) intake and prostate cancer (PCa). Plasma alkylresorcinol metabolites have been suggested as biomarkers for WG intake in free-living populations. Methods:We investigated the major dietary and lifestyle determinants of plasma alkylresorcinol metabolites in a nested case-control study (1,016 cases

Popular Abstract in Swedish Förståelse av hjärtats pumpförmåga är av yttersta vikt för att kunna behandla patienter med hjärtsjukdom, framförallt hjärtsvikt. Studier av hjärtat har av naturliga skäl framförallt gjorts med öppen bröstkorg eller med hjärtat uttaget ur kroppen, och detta påverkar hjärtats pumpning. Magnetresonans-kameran gör det möjligt att avbilda hjärtat i alla delar av hjärtcykelnCardiac pumping physiology is important for understanding the pathophysiology of patients with cardiac disease. MRI gives the opportunity to measure volumes and flow non-invasively with high accuracy and precision. This thesis examines some aspects on cardiac pumping physiology. Study I showed that the total heart volume in humans decreases during systole by ~8 % (range 5-11 %), and anatomically i

Popular Abstract in Swedish The overall interest pursued in this thesis is how the former socialist economies of Central and Eastern Europe can build strong and dynamic systems of innovation. The purpose of the thesis is to investigate the dynamics and evolution of the telecommunications system of innovation in Estonia from the late Soviet period to Estonia's EU accession, and to provide an in-depThe overall interest pursued in this thesis is how the former socialist economies of Central and Eastern Europe can build strong and dynamic systems of innovation. The purpose of the thesis is to investigate the dynamics and evolution of the telecommunications system of innovation in Estonia from the late Soviet period to Estonia's EU accession, and to provide an in-depth explanation of how innova

Popular Abstract in English From the pure technological perspective (leaving the business aside), the design of electronic devices, such as mobile phones, is an extremely complex process often involving a large number of disciplines, from mastering complicated mathematical models to proficiency of physical and electrical properties of specific materials involved in the manufacturing. In order to oThe methodology behind this work has been to use the concept of algorithm-hardware co-design to achieve efficient solutions related to the digital front-end in mobile receivers. It has been shown that, by looking at algorithms and hardware architectures together, more efficient solutions can be found; i.e., efficient with respect to some design measure. In this thesis the main focus have been plac

Special welcome issue 2020.pdf NEWSLETTER GRADUATE SCHOOL GRADUATE SCHOOL, FACULTY OF SOCIAL SCIENCES, LUND UNIVERSITY Special application issue 2020 All student newsaletters are available online: tinyurl.com/GSstudentnews (very handy, as they have clickable links) https://tinyurl.com/GSstudentnews https://tinyurl.com/GSstudentnews Letter from the Director of Studies 1 Thinking about coming to Lun

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/special_welcome_issue_2020_final.pdf - 2026-05-09

Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target TE families or unique TE loci. We also detail procedures for validating the efficiency and specificity of large-scale CRISPRi-based silencing using a multiome approach combining bulk RNA sequencing, C

AIMS: To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.METHODS: Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after

Behavioral, physiological, and life-history adaptations to the lunar cycle are global phenomena across trophic levels and ecosystems yet remain poorly understood because of the challenges of studying free-living organisms at night. We show that the lunar cycle regulates both daily foraging activity and foraging success in the red-necked nightjar-a nocturnal avian insectivore-and that moonless peri