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Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly target the pathological changes leading to increased IOP, which can manifest as medication resistance as disease progresses. To identify physiological modulators of IOP, we performed genome- and exome-wide association an
Background: The association between protein intake and prostate cancer risk remains unclear. Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid int
Opioid use disorders (OUD) is a relapsing condition with high mortality. Opioid maintenance treatment (OMT) reduces heroin use, and overall morbidity and mortality. The prevalence of psychiatric and substance use disorders, potential baseline predictors for psychiatric hospitalization, and psychiatric diagnoses at follow-up were investigated and may give hints about possible preventative strategie
The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addi
Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic resonance (CMR) can detect early signs of cardiovascular disease (CVD). The aim was to study if myocardial perfusion differs between healthy male
Limited data are available on the pathogenesis of HIV-2, and the evolution of Env molecular properties during disease progression is not fully elucidated. We investigated the intra-patient evolution of molecular properties of HIV-2 Env regions (V1–C3) during the asymptomatic, treatment-naïve phase of the infection in 16 study participants, stratified into faster or slower progressors. Most notably
Ectopic expression of transcription factor combinations has been recently demonstrated to reprogram differentiated somatic cells towards the dendritic cell (DC) lineage without reversion to a multipotent state. DCs have the ability to induce potent and long-lasting adaptive immune responses. In particular, conventional type 1 DCs (cDC1s) excel on antigen cross-presentation, a critical step for ind
Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, a
PurposeArterial stiffness is independently associated with orthostatic hypotension in older individuals. The relationship between orthostatic blood pressure adaptation and aortic stiffness has not been thoroughly examined in a younger population. We investigated the relationship between orthostatic blood pressure adaptations, central aortic hemodynamics, and aortic stiffness in a cohort of predomi
Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell injury in several metabolic organs, we here investigate its role in the main cell types of vasculature. We depleted STK25 by small interfering RNA in hum
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi
LUNDS UNIVERSITET 1 LUNDS UNIVERSITET KURSPLAN PPTP Institutionen för psykologi Psykodynamisk inriktning avseende barn & ungdom A. PPTT01. Kurs 1: Teoretisk bas (theoretical basis) Nivå A. 7 högskolepoäng Kursen är inrättad av Samhällsvetenskapliga fakultetsstyrelsen 2012-05-03 Kursplanen är fastställd av Institutionsstyrelsen vid Institutionen för psykologi 2012-06-05. Denna kursplan gäller från
https://www.psy.lu.se/sites/psy.lu.se/files/kursplandynamiskinriktningbarnoungdomny2012.pdf - 2026-05-20
Bakgrund: Pes Equino Varus Adductus (PEVA), även känt som klumpfot, är en medfödd felställning i fotens leder som kräver omfattande behandling under flera år. Det finns ett fåtal studier om hur PEVA påverkar barns grovmotoriska utveckling. Mer kunskap behövs om vilka faktorer som eventuellt kan påverka den grovmotoriska utvecklingen. Syfte: Att beskriva och jämföra utveckling av grovmotorik och pa
Nature-based solutions (NbS) have proven effective in addressing urban sustainability challenges. This thesis focuses on bridging the gap in NbS short-term interventions, scale, and financial barriers. It examines the instrumentalization and implementation of successful long-term interventions from a policy and urban governance perspective, aiming to inspire cities and identify commonalities. The
This study examines the relationship between global news narratives and market volatility, focusing on the VIX index as a measure of investor sentiment. By analyzing financial news headlines from 2023, the research investigates whether keyword frequencies related to terms like conflict, recession, and bullish can predict changes in VIX. The study employs multiple regression, time series analysis,
