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Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-side
Wnt5a, a member of non-canonical wingless-related MMTV integration site family is a secreted glycoprotein that plays important roles in development and disease. Recent studies have shown that Wnt5a protein levels are up-regulated in prostate cancer, but contrasting reports exist on the role of Wnt5a to predict outcome after radical prostatectomy in patients with localized prostate cancer. Our grou
Background: HIV-1 is one of the fastest evolving pathogens, and is distinguished by geographic and genetic variants that have been classified into different subtypes and circulating recombinant forms (CRFs). Early in infection the primary coreceptor is CCR5, but during disease course CXCR4-using HIV-1 populations may emerge. This has been correlated with accelerated disease progression in HIV-1 su
OBJECTIVE: To investigate the determinants and consequences of orthostatic hypotension in the middle-aged segment of the general population. METHODS: A population of 5722 men aged 52.6 +/- 3.6 years, previously included in the Malmö Preventive Project (n = 22 444 men), was re-screened after 5.6 +/- 1.0 years and thereafter followed up over a period of 19.6 +/- 5.3 years. RESULTS: At re-screening,
Functional studies of resident microglia require molecular tools for their genetic manipulation. Here we show that microRNA-9-regulated lentiviral vectors can be used for the targeted genetic modification of resident microglia in the rodent brain. Using transgenic reporter mice, we demonstrate that murine microglia lack microRNA-9 activity, whereas most other cells in the brain express microRNA-9.
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors and neurons from human embryonic stem cells, which recapitulates human fetal brain development. Through the addition of a small molecule that activates canonical WNT signaling, we induced rapid and efficient dose-dependent specification of r
The introduction of total prostate specific antigen (total PSA) testing in blood has revolutionized the detection and management of men with prostate cancer (PCa). The objective of this review was to discuss the challenges of PCa biomarker research, definition of the type of PCa biomarkers, the statistical considerations for biomarker discovery and validation, and to review the literature regardin
Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson's disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circuitry after transplantation remain largely unknown. In this study, we use modified rabies virus to trace afferent and efferent connectivity of transplan
The purpose of this study was to examine the subjective experience of schizophrenia. Four people, two of them diagnosed with schizophrenia and two relatives, were interviewed. The themes selected were development of the disease, recovery, belief in the future, the role of families and siblings, stigmatization and the relationship between violent crimes and mental illness. The development and exper
This paper intends to investigate the impact of the two-sided market effect with nearby theories, the importance of customer loyalty and customer relationship management in the newspaper industry. It takes its theoretical references from academic research literature and interviews with the focus on customer loyalty and customer relationship management in the two-sided market environment. The resu
Förändring av individens anknytning till sociala nätverk kan vara ett sätt att få en tidigare kriminell och/eller missbrukare att värdera ett konformt liv. Detta med en förhoppning om att ersätta individens kriminella värden och attityder till konforma sådana, genom att individen associerar och identifierar sig med gruppen (det sociala nätverket). Med utgångspunkt i denna idé är därför vårt syfte
In the 1940-ies curtain walls were introduced, i.e. brick walls that do not have any bearing function but served as a front material. Horizontal reinforcement was used in this kind of walls, partly over and under openings or, in undisturbed wall fields, every 5-6th bed joint. In this work the tensile bond strength of mortar joints repaired with an injection tool and a manual method respectively is
Begreppet adaptation to the adverse effects of climate change är relativt nytt in internationell miljörätt. Begreppet adaptation är inte definierat i UNFCCC. Den här uppsatsen analyserar adaptation i ljuset av begreppet reparation i internationell sedvanerätt. Uppsatsen undersöker vad begreppen adaptation och reparation har gemensamt. Kan adaptation i UNFCCC ses som en möjlig utveckling eller förlThe concept of adaptation to the adverse effects of climate change is relatively recent in international environmental law. Adaptation is not defined in the UNFCCC. This paper attempts to address adaptation in the UNFCCC from the perspective of reparation under customary international law. It investigates what the concepts of adaptation and reparation have in common. Could adaptation in the UNFCCC
This is an essay about the reconciliation process in Guatemala its focus is on investigating the strategies used and their results. The theoretical framework consists of reconciliation-theory with truth and justice as central concepts. The method used is a combination of abductive and theory consuming method with a qualitative approach that allows an in-depth study, which is necessary to understan
Since the first issuance in 1994, Swedish Government inflation indexed bonds have given a higher return then their nominal counterpart. This is despite the fact that investors can reduce the risks of inflation. Findings on other markets, as the US bond market, suggest that the higher return can be explained by the lower liquidity of inflation indexed bonds relative the nominal bonds. The aim of th
