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Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants exp

Asthma and allergies are common diseases in adolescents and have increased during the last few decades. All elite level sports activities result in increased risk of asthma and rhinitis regardless of sport practised. Physical activity is at the same time regarded as a health-promoting factor and is recommended both for the prevention and treatment of diseases. The aim of this study was to explore

We have recently shown that low plasma levels of mid-regional atrial natriuretic peptide (MR-ANP) predict development of diabetes and glucose progression over time, independently of known risk factors for diabetes development. However, since MR-ANP levels might be influenced by unknown factors causing diabetes, we cannot rule out that such relationship might be confounded. Previous studies have sh

BACKGROUND: Restrictions in social and leisure activity can have negative consequences for the health and well-being of stroke survivors. To support the growing number of people who are ageing with stroke, knowledge is needed about factors that influence such activity in a long-term perspective. AIM: To identify long-term predictors of the frequency of social and leisure activities 10 years afte

The aim of this study was to examine breast density in relation to breast cancer specific survival and to assess if this potential association was modified by mode of detection. An additional aim was to study whether the established association between mode of detection and survival is modified by breast density.

Spark ablation is an advantageous method for the generation of metallic nanoparticles with defined particle sizes and compositions. The reaction of the metal particles with the carrier gas during the synthesis and, therefore, the incorporation of those light elements into structural voids or even compound formation was confirmed for hydrides and oxides but has only been suspected to occur for nitr

α-Synuclein is a synaptic protein that accumulates primarily in synucleinopathies and secondarily in certain lysosomal storage disorders. However, its physiological roles in health and disease are not fully understood. In part, this has been hampered by the inability to visualize α-synuclein and its cellular localization, due to the lack of specific antibodies and faithful reporters. Here, we used

In recent decades, working with computers has evolved from a specialized area to a requirement at most workplaces. Information systems also change regularly and employees have to adapt to new computer systems. However all individuals do not like computer work and the concept of computer anxiety describes human attitudes to computers. This study examined how computer anxiety is influenced by an inf

In the 1940-ies curtain walls were introduced, i.e. brick walls that do not have any bearing function but served as a front material. Horizontal reinforcement was used in this kind of walls, partly over and under openings or, in undisturbed wall fields, every 5-6th bed joint. In this work the tensile bond strength of mortar joints repaired with an injection tool and a manual method respectively is

Event är korta tidsintervall som skiljer längre episoder med stabila oceaniska förhållanden från varandra. När cirkulationen i världshaven tillfälligt stängs av under ett event förändras fauna- och bergartssammansättningen, och även isotopförhållandena. Målet med detta arbete har varit att utröna hur de sensiluriska brachiopoderna reagerade på det globalt kända Lau Event. På Gotland omfattar det lThe impact of the Ludfordian Lau Primo-Secundo Event on brachiopods from Gotland has been investigated. About 12 000 individuals were identified from five samples. The results are supplemented by an extensive literature study. On Gotland, the Lau Event spans the Botvide Mbr (uppermost När Fm, upper Hemse Group) and the Eke Fm. It caused extinctions, faunal, sedimentary and isotopic changes. Conodo

In the beginning of the 1990’s community service was introduced at a couple of Swedish courts as an experiment. It was to be a compliment to probation and together the two were supposed to be considered the equivalent in harshness of a shorter prison sentence. After a few years the experiment was extended to all Swedish courts and by the end of the decade community service was made a permanent par

Begreppet adaptation to the adverse effects of climate change är relativt nytt in internationell miljörätt. Begreppet adaptation är inte definierat i UNFCCC. Den här uppsatsen analyserar adaptation i ljuset av begreppet reparation i internationell sedvanerätt. Uppsatsen undersöker vad begreppen adaptation och reparation har gemensamt. Kan adaptation i UNFCCC ses som en möjlig utveckling eller förlThe concept of adaptation to the adverse effects of climate change is relatively recent in international environmental law. Adaptation is not defined in the UNFCCC. This paper attempts to address adaptation in the UNFCCC from the perspective of reparation under customary international law. It investigates what the concepts of adaptation and reparation have in common. Could adaptation in the UNFCCC

This is an essay about the reconciliation process in Guatemala its focus is on investigating the strategies used and their results. The theoretical framework consists of reconciliation-theory with truth and justice as central concepts. The method used is a combination of abductive and theory consuming method with a qualitative approach that allows an in-depth study, which is necessary to understan

Since the first issuance in 1994, Swedish Government inflation indexed bonds have given a higher return then their nominal counterpart. This is despite the fact that investors can reduce the risks of inflation. Findings on other markets, as the US bond market, suggest that the higher return can be explained by the lower liquidity of inflation indexed bonds relative the nominal bonds. The aim of th