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Immortalized erythroid cell lines are expected to be a promising source of ex vivo manufactured red blood cells (RBCs), however the induction of enucleation in these cell lines is inefficient at present. We utilized an imaging-based high-throughput system to identify chemical compounds that trigger enucleation of human erythroid cell lines. Among >3,300 compounds, we identified multiple histone de
Objective: Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVneo) was exposed to various concentrations of PM2.5 (PM2.5) in order to elucidate the effect of urban
Culture-expanded mesenchymal stromal cells (MSCs) are promising candidates for clinical cell-based therapies. MSC products are heterogeneous and we therefore investigated whether acoustophoresis, an ultrasound-based separation technology, could be used for the label-free enrichment of functionally different MSC populations. Acoustophoresis uses an ultrasonic standing wave in a microchannel which d
Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments. A meta-analysis to quantify the effect modified by the predictors using individual patient data (IPD) is suggested. The initia
The prospect of being able to efficiently inject large plasmids in insulin-producing beta cells is very attractive for diabetes research. However, conventional transfection methods suffer from high cytotoxicity or low transfection efficiency, which negatively affect their outcome. In contrast, nanostraw electroporation is a gentle method that can provide a high transfection efficiency while mainta
The purpose of the present chapter is to outline the principles of experimental phenomenology as an approach to research on spirituality. Experimental phenomenology is the investigation of phenomenological practices and their impact. Essential to phenomenological practices is that they involve intentional variations of experiencing by means of changes in the direction of attention and the choice oThe purpose of the present chapter is to outline the principles of experimental phenomenology as an approach to research on spirituality. Experimental phenomenology is the investigation of phenomenological practices and their impact. Essential to phenomenological practices is that they involve intentional variations of experiencing by means of changes in the direction of attention and the choice o
BackgroundIn the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, an
Aging profoundly affects the immune system leading to an increased propensity for inflammation. Age-related dysregulation of immune cells is implicated in the development and progression of numerous age-related diseases such as: cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. Monocytes and monocyte-derived macrophages, being important players in the inflammatory resp
Sustainable Aviation Fuels (SAF) typically exhibit a composition that differs significantly from conventional jet fuels. These variations in chemical makeup influence the thermophysical and reactive properties of these propellants. In this study, Finite-Rate Chemistry (FRC) Large Eddy Simulations (LES) are employed to investigate turbulent spray flames from a Triple Annular Research Swirler (TARS)
Objective: Humanrhinovirus is the most common cause of the common cold worldwide (1). It hasbeen shown that a substantial part of the airborne viruses is found in aerosolparticles in the range of 1-4 µm (2). Studying the infectivity of aerosolparticles in this range is, however, challenging; therefore, not many studieshave been conducted on their infectivity. The aim of this work is toinvestigate
The formation of copper phosphide phases during brazing can negatively impact the mechanical properties of copper joints and the overall performance of the resulting product. For instance, copper tubes in air conditioning heat exchangers are brazed using Cu-P filler alloy, resulting in unnecessary brittle Cu₃P compounds. This study investigates a novel process of dephosphorization of copper phosph
Lost Farm Festival transformed an abandoned farm into a global gathering point for grief, anger and creativity – where concerts, rituals and installations turned Sjællands Odde into a new center of the world.
Background: Brief Admission by self-referral (BA) is a crisis-management intervention standardized for individuals with self-harm at risk of suicide. We analyzed its health-economic consequences. Materials and methods: BA plus treatment as usual (TAU) was compared with TAU alone in a 12-month randomized controlled trial with 117 participants regarding costs for hospital admissions, coercive measur
Metastable cubic tin(II) sulfide (π-SnS) is an earth-abundant semiconductor whose three-dimensionally bonded chiral lattice may overcome the short minority-carrier lifetime of orthorhombic SnS while maintaining a near-ideal bandgap for tandem photovoltaics. Despite its promise, ultrafast carrier cooling and recombination mechanisms over illumination density remain poorly constrained. We use core-l
The global steel industry accounts for 8–10 % of global CO2 emissions and requires deep decarbonisation for achieving the targets set in the Paris Agreement. However, no low-emission primary steel production technology has yet been commercially feasible or deployed. Through analysing revisions and additions of European Union climate policy, we show that green hydrogen-based steelmaking in competit
Transfecting clonal beta cells with large DNA plasmids holds significant promise for diabetes research. Existing transfection techniques like lipofection, viral transduction, and bulk electroporation often face limitations such as low efficiency and cytotoxicity. Nanoelectroporation, which utilizes nanopores or nanostraws and the application of mild electrical pulses, offers a gentle and safe alte
In Singapore, children’s education is often presented as “an overriding and all-consuming concern,” driven by intense competition for grades and school admissions (Waters, 2015: 290). However, the desire for academic excellence as a pathway to better lives is not as straightforward as it may seem. Drawing on ethnographic fieldwork with Singaporean families, this paper explores parents’ affective a
Information and communication technologies (ICTs) become more advanced and more accessible which leads to new ways of work. A rather new phenomenon is that of location independent workers (LIWs), who are enabled by these technologies to work while traveling the world. New ways of working assumingly lead to changes in the work-nonwork interface. This study takes a demands and resources approach to
LÖRDAG 27 JUNI Cirkusmingel med Momo och Ross Stortorget 13.00–16.00 SÖNDAG 28 JUNI Vilda ätliga växter Skrylle, Naturum 10.45–14.00 Offentliga konstverk i stadsparken Samling vid fontänen vid musik- paviljongen 13.00–14.00 Barbra Streisand: Från ful ankunge till glamorös Funny Girl –med Lasse Walldov Stadsparken, Lilla Vita 18.00–19.00 MÅNDAG 29 JUNI Kulturhistorisk stadsvandring i Nöden Samling
https://www.botan.lu.se/sites/botan.lu.se/files/sommarlund2020_program_web_print.pdf - 2026-06-28
