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We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female

For patients with gastroenteropancreatic neuroendocrine tumours (GEP-NET), health-related quality of life (HRQoL) is important. Meanwhile, whether tumour volume is associated with HRQoL is unknown. Hence, the aim of this study was to assess if total somatostatin receptor expressing tumour volume is correlated with HRQoL in patients with metastatic GEP-NET. Some 71 patients were included in the stu

Nickel-based superalloys are known to be difficult to machine. These alloys are generally machined with cemented carbide tools under low productivity process conditions. Superhard polycrystalline cubic boron nitride (PcBN) tooling offers the possibility of increased production rates, however, a thorough understanding of the material performance and degradation is required before a transition from

Det övergripande syftet med denna avhandling är att främja den konceptuella förståelsen av transformativ innovationspolitik genom empirisk forskning med fokus på omställningen till en cirkulär ekonomi i den danska avfallssektorn. Under detta breda syfte handlar avhandlingen mer specifikt om att utforska frågor relaterade till geografi i transformativ innovationspolitik samt såkallad övergångsdynamThe overall aim of this thesis is to advance the conceptual understanding of transformative innovation policy through empirical research focusing on the transition towards a circular economy in the Danish waste sector. Under this broad aim, the thesis is more specifically concerned with exploring issues relating to the geography of transformative innovation policy as well as transition dynamics an

The categories and concepts in the existing official land-use maps have been under improvements over recent years; however, this study from Nordland, northern Norway, shows that they continue to pose several dilemmas when aiming to better capture the impacts of multiple land uses on reindeer herding. While these developments have done much to better communicate the presence of reindeer herding to

Fluorescence sensing plays an increasingly important role in biology and biomedicine. For many practical applications of fluorescent probes, an “off-on” response is preferred. The question of how fluorescence quenching/enhancement occurs is fundamental and of high importance for application and design of new fluorescent probes. The sensing mechanism of an aminorhodamine (TMARh) pH probe is investi

The Memorial Sloan Kettering Cancer Center (MSKCC) recommendations on prostate cancer screening were developed in response to three limitations of previous screening guidelines: insufficient evidence base, failure to link screening with treatment, and lack of risk stratification. The objective of the recommendations is to provide a schema for prostate cancer screening that maximizes the benefits,

The Keccak sponge function family, designed by Bertoni et al. in 2007, was selected by the U.S. National Institute of Standards and Technology (NIST) in 2012 as the next generation of Secure Hash Algorithm (SHA-3). Due to its theoretical and practical importance, cryptanalysis of SHA-3 has attracted a lot of attention. Currently, the most powerful collision attack on SHA-3 is Jian Guo et al.’s lin

Introduction: There is a great need for fully automated plasma assays that can measure amyloid beta (Aβ) pathology and predict future Alzheimer's disease (AD) dementia. Methods: Two cohorts (n = 920) were examined: Panel A+ (n = 32 cognitively unimpaired [CU], n = 106 mild cognitive impairment [MCI], and n = 89 AD) and BioFINDER-1 (n = 461 CU, n = 232 MCI). Plasma Aβ42/Aβ40, phosphorylated tau (p-

Purpose: To describe performed moral case deliberations and present a nationwide study of difficult situations and moral questions raised by healthcare professionals during moral case deliberations in Swedish childhood cancer care. Methods: Written reports (n = 72) about difficult situations and moral questions were completed by healthcare professionals, trained as facilitators, who implemented mo

Purpose: Accuracy investigation of volumetric navigators for motion correction, with emphasis on geometric EPI distortions at ultrahigh field. Methods: High-resolution Dixon images were collected in different head positions and reconstructed to water, fat, T2*, and B0 maps. Resolution reduction was performed, and the T2* and B0 maps were used to apply effects of TE and EPI distortions to simulate

There is a growing interest in industry and academia in machine learning (ML) testing. We believe that industry and academia need to learn together to produce rigorous and relevant knowledge. In this study, we initiate a collaboration between stakeholders from one case company, one research institute, and one university. To establish a common view of the problem domain, we applied an interactive r

The Paris Agreement establishes a transparency framework for anthropogenic carbon dioxide (CO2) emissions. It's core component are inventory-based national greenhouse gas emission reports, which are complemented by independent estimates derived from atmospheric CO2 measurements combined with inverse modelling. It is, however, not known whether such a Monitoring and Verification Support (MVS) capac

Purpose: Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor-valued diffusion encoding and joint relaxation-diffusion quantification enable more reliable quantification of compa

Purpose: This study aimed to quantify the relationship between objective and subjective measures of functional ability and determine if measures in the deficient (ACLd) state were correlated to, and capable of predicting a patient's objective and subjective measures in the reconstructed (ACLr) state. Methods: Twenty ACL-injured participants completed hop and side cut movements prior to and 10 mont

The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘proto