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Objective: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. Methods: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to e
Objectives: To identify characteristics of older adult emergency department (ED) patients aged ≥65 with suicidal ideation and/or behavior. Methods: A single center retrospective chart review analyzed 392 patients (≥65) with suicidal ideation and/or behavior (2013–2019). Comprehensive full-text searches were used. Subgroup analyses for age and gender were conducted. Results: Depressive disorder was
BACKGROUND: Parents experience a range of mental health disorders following their child's cancer diagnosis. It is thus essential to explore how the child's cancer diagnosis affects the dosage of psychotropic medication in both short- and long-term use, as well as potential disparities in utilization patterns between mothers and fathers.PATIENTS AND METHODS: Using Swedish registers, we identified a
ADP-ribosyltransferase ARTD1/PARP1 is a target for cancer and ischemia drug development. Several other ARTD-family enzymes have been characterized in recent years, and it has become clear that their inhibition might also have therapeutic value. This minireview series summarizes current knowledge of pharmacological inhibition of ADP-ribosyltransferases by a compound class called PARP inhibitors and
Maternal vaccination, resulting in transfer of protective IgG across the placenta, represents a promising strategy to prevent neonatal disease caused by group B Streptococcus (GBS). The prototype vaccine GBS-NN, a fusion protein consisting of the N-terminal domains of the alpha-like protein (Alp) family members AlphaC and Rib, has been shown to display a good safety profile and to elicit a strong
Pregnancy-induced immune modulation might lead to reactivation of latent tuberculosis infection (LTBI). This thesis explores aspects of immune-based LTBI diagnostics and how pregnancy affects the immune control of Mycobacterium tuberculosis (Mtb) infection. We studied a prospective cohort of women recruited during pregnancy in Ethiopia. LTBI testing was performed by quantification of interferon-γ
Background: Physical meetings are favoured in social care and home health service in Sweden, both when it comes to internal meetings or home visits at citizens residence. During the pandemic, physical meetings were supposed to decrease as much as possible to avoid the virus to spread. One solution was to digitize as many meetings as possible. Transforming meetings from physical to digital is not w
Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid biomarkers. Our approach involves the utilization of 6-carboxyfluorescein modified singl
Objective: To study the efficacy of psoralen with ultraviolet A photochemotherapy (PUVA) and narrowband ultraviolet B phototherapy (NBUVB), for early-stage mycosis fungoides (MF) in Thais. Materials and Methods: A retrospective medical chart review of 50 cases was performed. Demographic data, type of phototherapy, duration of treatments, clinical response, relapse, and adverse effects were analyze
OBJECTIVES: To compare sociodemographic, clinical, and suicide-specific characteristics between younger old (aged 65-74) and older old (aged 75+) adults who died by suicide in 2015, and to identify clinically relevant subgroups in the entire study cohort 65+ through cluster analysis.DESIGN: Retrospective cohort study.SETTING: All health care units across Sweden.PARTICIPANTS: Individuals aged 65+ w
Population ageing means that increasingly many are faced with the dual demands of paid work while providing unpaid care to older family members. Caregiving requires time and energy, with implications for paid work and well-being. The challenges faced by individuals add up and therefore also impact national economies. This dissertation provides insights into the implications of unpaid caregiving fo
In a large case-control study of Swedish incident type I diabetes patients and controls, 0–34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients.
Popular Abstract in Swedish Arbetet i denna avhandling har lett till en ökad förståelse av proteinet SOX11:as roll som biomarkör för äggstockscancer och B-cells-lymfom vilket förhoppningsvis kommer att resultera i enklare diagnos, bättre prognostik samt eventuellt nya terapier för dessa cancertyper. Var tredje person i Sverige beräknas få en cancerdiagnos någon gång i livet och statistiken är likIt is estimated that one third of all people in Sweden will be diagnosed with cancer during their lifetime. The outcome for a specific patient is related to early and correct diagnosis, and prediction of effective treatment regimens. Biomarkers are molecules that can aid the clinician in such decisions regarding diagnosis, prognosis and therapy. In this thesis, based on five original papers, the
This paper presents a theoretical analysis of the neoliberal production of anxiety in academic faculty members in universities in Northern Europe. The paper focuses on neoliberalization as it is instantiated through audit and ranking systems designed to produce academia as a space of economic efficiency and intensifying competition. We suggest that powerful forms of competition and ranking of acad
Det första skedet när ett byggnadsverk ska uppföras är det konceptuella designskedet, det är här de första besluten om utformningen av byggnadsverket görs. I det traditionella arbetsflödet utformas byggnadsverket först i ett ritprogram, sedan används ett annat datorverktyg för att verifiera att det utformade byggnadsverket kan hantera de krafter som uppstår, t.ex. vind, egentyngd osv. Detta arbeteBefore a new structure can be built, it must be designed. This design phase is a very important step in the building process. The total cost of the structure and its structural performance are largely dependent on the structural design process. The impact of decisions on the design process is initially high and declines as the design matures. However, few computational tools are available for the
Popular Abstract in Swedish Människans immunförsvar har utvecklats under miljontals år för att i bästa möjliga mån skydda oss från infektioner och det sköter i de allra flesta fall det jobbet utmärkt. Ibland händer det dock att någonting går fel och konsekvensen kan bli väldigt obehaglig eller till och med förödande för den drabbade. Allergiska reaktioner är ett utmärkt exempel på en sådan situatiAntibodies of the IgE isotype play a key role as the allergen recognizer in allergic disease, which today affects as much as a third of the population in the industrialized parts of the world. Despite this crucial role of IgE, our knowledge of IgE repertoires and how we can utilize the information hidden in monoclonal IgE to improve the quality of life of allergic patients, is limited. This thesis
Evolutionary prediction and control are increasingly interesting research topics that are expanding to new areas of application. Unravelling and anticipating successful adaptations to different selection pressures becomes crucial when steering rapidly evolving cancer or microbial populations towards a chosen target. Here we introduce and apply a rich theoretical framework of optimal control to und
