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A fully integrated 0.6 V 2.6 mA VCO aimed for the GPS L1 band is realized in a 90 nm CMOS process. The VCO operates at 6.3 GHz and a divide-by-four circuit buffer provide the wanted 1575.42 MHz signal. The VCO has a measured phase noise of-103 dBc/Hz at 100kHz offset and a chip area of 1.15mm ², including bondpads.

Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov

Accessible design enables participation in the digital society for everyone. However, cognitive accessibility is not well established within the field of web design. The International Classification of Functioning, Disability and Health (ICF) provides a descriptive framework that relates health conditions to functioning and participation. ICF Core Sets are purposefully tailored shortlists of ICF c

To predict major pressure losses from pumping shear thinning liquid foods and beverage, rheometer-measured flow behaviour (n) and flow consistency (K) indices are needed. These are always obtained with some measurement uncertainty. This contribution develops a tool that allows for quantitatively estimating how a given measurement uncertainty in the rheological parameters translate to predictio

Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de

BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl

Climate change is one of the major drivers of biodiversity loss. Among vertebrates, amphibians are one of the more sensitive groups to climate change due to their unique ecology, habitat requirements, narrow thermal tolerance and relatively limited dispersal abilities. We projected the influence of climate change on an endemic toad, Malabar Tree Toad (Pedostibes tuberculosus; hereafter MTT) from t

The governance of agricultural resources, particularly seeds, has long been a site of contestation between corporate-aligned institutions promoting proprietary seed laws and smallholder farmers, civil society organisations, and food sovereignty advocates defending traditional seed systems and local control. In Ghana, the introduction and eventual passage of the Plant Variety Protection Act of 2020

The Siusi/Seis section has been measured for the δ13C signature across the Permian-Triassic Boundary (PTB) in high resolution on magnetostratigraphic samples from Scholger et al. (2000), enabling an exact correlation with magnetostratigraphic data. We show that the base of the short normal polarity magnetozone that has been reported from the evento-stratigraphic boundary correlates with a distinct

Tensor-valued encoding in diffusion MRI allows probing of microscopic anisotropy in tissue, however, time-dependent diffusion (TDD) can bias results unless b-tensors are carefully tuned to account for TDD. We propose two novel strategies for tuning b-tensors to enable accurate measurements without interference from TDD due to restricted diffusion. The first strategy involves identifying encoding t

As decolonization transformed world geopolitics, various Eastern Europeanauthoritarian ultranationalist groups sought to instrumentalize anti-imperialism in their attempts to launch a violent overthrow of the socialist regimes of the Soviet bloc. As the USSR underwent a transformation from the radical anti-imperialism of the 1920s to certain imperial attributes following the announcement of the BrAs decolonization transformed world geopolitics, various Eastern Europeanauthoritarian ultranationalist groups sought to instrumentalize anti-imperialism in their attempts to launch a violent overthrow of the socialist regimes of the Soviet bloc. As the USSR underwent a transformation from the radical anti-imperialism of the 1920s to certain imperial attributes following the announcement of the Br

Phylogenies are central to many disciplines in biology. While disciplines such as systematics are focused on phylogenetic hypotheses themselves, other disciplines depend on robust and well-supported phylogenies in order to put biological data into evolutionary context through phylogenetic comparative studies. Examples of such fields are macroevolutionary research e.g. studying the evolution of a f

Monitoring toxic elements has a long tradition in Slovenia due to historical mining. More recently, attention has shifted to essential elements, since both deficiencies and excesses can harm health. Regular monitoring of (non-)essential elements supports risk assessment and policymaking. While urine and blood are common biomonitoring matrices, hair offers a non-invasive alternative that reflects e

Access to outdoor leisure activities is central to supporting active and healthy ageing. To address the lack of research on services supporting continued engagement, this study examines how public, voluntary and private sectors provide outdoor recreation services for older adults. This study uses a qualitative research design to draw on interviews, a workshop, and field observations conducted in a

The theory of ecologically unequal exchange (EUE) posits that international trade is structurally organized in a manner that allows a net transfer of resources from peripheral developing to core industrialized countries. The consequence, it is argued, is under-development in the periphery and augmented productive capacity in the core. EUE thus challenges the neoliberal free-market argument that ex

A search for top quark pair resonances in final states containing at least one electron or muon has been performed with the ATLAS experiment at the CERN Large Hadron Collider. The search uses a data sample corresponding to an integrated luminosity of 2.05 fb(-1), which was recorded in 2011 at a proton-proton centre-of-mass energy of 7 TeV. No evidence for a resonance is found and limits are set on

This Letter presents a search for singly produced vector-like quarks, Q, coupling to light quarks, q. The search is sensitive to both charged current (CC) and neutral current (NC) processes, pp -> Qq -> Wqq' and pp -> Qq -> Zqq' with a leptonic decay of the vector gauge boson. In 1.04 fb(-1) of data taken in 2011 by the ATLAS experiment at a center-of-mass energy root s = 7 TeV, no evidence of suc

A search for a heavy, CP-odd Higgs boson, A, decaying into a Z boson and a 125 GeV Higgs boson, h, with the ATLAS detector at the LHC is presented. The search uses proton-proton collision data at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 20.3 fb(-1). Decays of CP-even h bosons to tau tau or bb pairs with the Z boson decaying to electron or muon pairs are conside