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Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the peroxide regulator PerR, in an M1 serotype of Streptococcus pyogenes. To determine the role of PerR in S. pyogenes, we inactivated the gene by allelic replacement. PerR-deficient bacteria showed 48% reductio

Daniel Quinn is the protagonist in Paul Auster's novel City of Glass. This essay traces his development chronologically to assess his search for, need of, and eventual lack of an identity.

Klimatförändringarna tvingar miljontals människor världen över att lämna sina hem, men det juridiska skyddet för dem som flyr miljörelaterade kriser är fortfarande otydligt och fragmenterat. 1951 års flyktingkonvention erbjuder viktiga skydd för personer som flyr förföljelse, men omfattar inte individer som fördrivs av klimatförändringar, vilket skapar betydande luckor i den internationella rättenClimate change is displacing millions globally, yet legal protections for those fleeing environmental crises remain unclear and fragmented. The 1951 Refugee Convention offers critical safeguards for those fleeing persecution but excludes individuals displaced by climate change, leaving significant gaps in international law. This raises pressing questions: How can international law address the chal

Background: As worldwide life expectancy increases, the Swedish Ambulance Service is likely to be affected by the demographic shift towards a larger proportion of older persons. An older population tends to increase the demand for ambulances, indicating a need to illuminate older patients’ perspective. Thus, the aim of this study was to explore older patients’ perceptions of the Swedish Ambulance

Drawing on data from the United Kingdom, Sweden, Germany, and Switzerland, this article shows that during the process of interpreting the refugee definition and applying it to the context of the Eritrean Military/National Service Programme (MNSP), the definition is subject to various interpretations and applications. As a result, the treatment of similarly situated Eritrean asylum applications dif

Directional crack growth criteria in compressed elastic–plastic materials are considered. The conditions at the crack tip are evaluated for a straight stationary crack. Remote load is a combined hydrostatic stress and pure shear, applied via a boundary layer assuming small scale yielding. Strains and deformations are assumed to be small. Different candidates for crack path criteria are examined. M

Välkommen till Institutionen för hälsovetenskaper, en av sex institutioner vid Medicinska fakulteten, Lunds universitet. Genom vår forskning ökar vi kunskapen och förståelsen om människors hälsa och livskvalitet. Hälsofrämjande och förebyggande insatser, behandlande åtgärder, vård och omsorg och rehabilitering är centrala forskningsområden. Vi arbetar i nära samarbete med hälso- och sjukvård och kThe Department of Health Sciences is one of six departments at the Faculty of Medicine, Lund University. We conduct research within the field of health sciences. Health promotion and prevention efforts, Treatment measures, Health and social care and Rehabilitation are key research areas. We work in close collaboration with health care and municipalities to translate research results into practical

Hjärt-kärlsjukdom är världens vanligaste dödsorsak. Det främsta underliggande tillståndet är ateroskleros: plack som bildas i blodkärlens väggar och kan orsaka akuta komplikationer, såsom hjärtinfarkt och stroke. Genom vår forskning ämnar vi identifiera kliniska metoder som kan hjälpa oss att hitta plack med hög komplikationsrisk, för att i tid kunna ge adekvat förebyggande behandling. Vi vill äveCardiovascular disease is the most common cause of death. The main underlying condition is atherosclerosis: plaques formed in the arteries which can cause complications as stroke or myocardial infarction. Our research aims to prevent complications by identifying clinical methods to detect patients with high-risk plaques to personalize treatment strategies as well as novel mechanisms to use as ther

Existing metastatic disease represents a major clinical challenge. The long-term goal of our study is to gain deeper understanding of cellular mechanisms underlying cancer metastasis. We focus on identification and validation of new predictive biomarkers and drug targets that are specifically for metastatic cancer. We recently focus on studying the role of lipid kinases in particular, phosphatidyl

AimsTo assess the variation in ovarian carcinoma type diagnosis among gynaecological pathologists from Nordic countries, and whether a rationally designed panel of immunohistochemical markers could improve diagnostic reproducibility. Methods and resultsEight pathologists from four countries (Sweden, Denmark, Norway, and Finland) received an educational lecture on the diagnosis of ovarian carcinoma

Allteftersom stora framsteg görs i datorernas värld och inom artificiell intelligens ser samhället en allt större implementering av artificiell intelligence-teknologi i människors vardag. En sådan implementering är autonoma, självkörande, fordon. Detta är en teknologi som lovar stora framsteg inom fordonssäkerhet, lägre utsläpp till följd av mindre köbildning och en rad andra samhällsvinster. Det

Mervärdeskatterätten utgör ett fullständigt harmoniserat område inom EU och medlemsstaternas lagstiftning på området är till sin helhet baserad på EU rätten. En uniform tillämpning av momsreglerna i medlemsstaterna är av stor vikt för mervärdesskattesystemets funktion. Skyldigheten att tolka nationell lag i enlighet med EU rätten är därför ett viktigt instrument för att säkerställa en uniform tillThe area of VAT constitutes a completely harmonized area within the EU and the national provisions in this area are to their entirety based on EU law. A uniform application of the VAT provisions throughout the EU therefore becomes essential in order to ensure the proper function of the VAT system. The obligation for national courts to interpret national law in conformity with EU law becomes an imp