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The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow
Background: Apnea of prematurity is a common problem in preterm infants that may have significant consequences on their development. Methylxanthines (aminophylline, theophylline, and caffeine) are effective in the treatment of apnea of prematurity. Doxapram is used as a respiratory stimulant in cases refractory to the methylxanthine treatment. Objectives: To evaluate the benefits and harms of doxa
Microbial contaminants are responsible for several infectious diseases, and they have been introduced as important potential food- and water-borne risk factors. They become a global burden due to their health and safety threats. In addition, their tendency to undergo mutations that result in antimicrobial resistance makes them difficult to treat. In this respect, rapid and reliable detection of mi
This chapter brings the Global South to the centre stage of degrowth debates to envision what a truly global and anti-colonial movement towards degrowth could look like. To do so, we first bring the varying definitions of the term ‘Global South’ to the forefront and consider the Global South not as an undynamic and apolitical cate- gory, but as a site of resistance and independent critical thinkin
The discussion on the Anthropocene has increased the urgency to promote a sustainable society, considering the planetary boundaries, population growth and resource scarcity. Thus, the United Nations created the 2030 Agenda for Sustainable Development to address this challenge, including 17 Sustainable Development Goals (SDGs) and 169 SDG targets. In this context, the energy sector is one of the ma
The flavour-tagging algorithms developed by the ATLAS Collaboration and used to analyse its dataset of s=13 TeV pp collisions from Run 2 of the Large Hadron Collider are presented. These new tagging algorithms are based on recurrent and deep neural networks, and their performance is evaluated in simulated collision events. These developments yield considerable improvements over previous jet-flavou
Performance of a proton exchange membrane (PEM) fuel cell is very sensitive to its electric resistance appearing in its functional components. In this paper, the electric resistance as well as related parameters of a cell is evaluated by a recently developed numerical method in the through-plane direction of the electrodes. The results show that the channel/rib structure leads to non-homogeneous e
BACKGROUND: Perinatal stroke refers to a diverse but specific group of cerebrovascular diseases that occur between 20 weeks of fetal life and 28 days of postnatal life. Acute treatment options for perinatal stroke are limited supportive care, such as controlling hypoglycemia and seizures. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, or regenerate injured bra
The cooperative emission of interacting nanocrystals is an exciting topic fueled by recent reports of superfluorescence and superradiance in assemblies of perovskite nanocubes. Several studies estimated that coherent coupling is localized to a small fraction of nanocrystals (10−7-10−3) within the assembly, raising questions about the origins of localization and ways to overcome it. In this work, w
Previous research has identified good communication as one of several key factors essential for destination resilience. However, there has been a lack of research on how communication contributes to this development. To address this gap, this study explores the communication work done by Destination Management Organizations (DMOs) with stakeholders to influence destination resilience. The study ex
The Cherenkov Telescope Array (CTA) will be the next generation ground-based observatory for very-high-energy (VHE) gamma-ray astronomy, with the deployment of tens of highly sensitive and fast-reacting Cherenkov telescopes. It will cover a wide energy range (20 GeV - 300 TeV) with unprecedented sensitivity. To maximize the scientific return, the observatory will be provided with an online softwar
Introduction: With the rapid development of treatment modalities for obesity management, there is a growing need for guidelines. This was acknowledged by the Swedish National Board of Health and Welfare and in 2020 the process of producing the first national guidelines for obesity care, including both children and adults, was initiated. The main aim was to ensure equal high standard care throughou
Here, we present new models to fit small angle X-ray scattering (SAXS) data for the characterization of ion tracks in polymers. Ion tracks in polyethylene terephthalate (PET), polycarbonate (PC), polyimide (PI) and polymethyl methacrylate (PMMA) were created by swift heavy ion irradiation using 197Au and 238U with energies between 185 MeV and 2.0 GeV. Transmission SAXS measurements were performe
While the conventional forest plot is useful to present results within subgroups of patients in clinical studies, it has been criticized for several reasons. First, small subgroups are visually overemphasized by long confidence interval lines, which is misleading. Second, the point estimates of large subgroups are difficult to discern because of the large box representing the precision of the esti
Weather impacts several aspects of our daily life, of which the way we travel is one. The relationship between weather phenomena and ridership of trains has not received much attention previously. The study we present here aims to understand the impact of temperature, wind, and precipitation on passenger volumes for commuter trains. To do so we make use of automatic passenger count and weather dat
Background: The international multi-center randomized controlled STEPCARE-trial will investigate optimal management of sedation, temperature, and mean arterial pressure (MAP) during intensive care in out-of-hospital cardiac arrest (OHCA) patients due to various etiologies. The primary outcome is mortality at 6 months. This protocol describes an extended follow-up sub-study of the STEPCARE-trial wi
This paper presents a search for a new Z′ resonance decaying into a pair of dark quarks which hadronise into dark hadrons before promptly decaying back as Standard Model particles. This analysis is based on proton-proton collision data recorded at s = 13 TeV with the ATLAS detector at the Large Hadron Collider between 2015 and 2018, corresponding to an integrated luminosity of 139 fb−1. After sele
Groundwater, as a vital water resource in arid and semi-arid regions, plays a crucial role in sustaining human livelihoods, agriculture, and industry. Over recent decades, these areas have witnessed rapid groundwater depletion, raising concerns about resource sustainability. This research provides a comprehensive analysis of the factors contributing to the decline in groundwater levels (GWL) withi
