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Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well as informative of biology. Herein, we employed a population-based metastatic melan

Researchers at Lund University in Sweden have conducted a clinical study to show how a woman’s genetic profile provides information on which hormone treatment is most effective for in vitro fertilisation (IVF). The researchers have now developed a simple oral swab test that shows which hormone therapy is the best option for IVF treatment About 15 per cent of all couples of reproductive age are inv

https://www.lunduniversity.lu.se/article/higher-success-rate-using-simple-oral-swab-test-ivf - 2025-11-24

BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee

Metformin is the first-line drug that can lower blood sugar levels in type 2 diabetes patients. One third of patients do not respond to metformin treatment and 5 per cent experience serious side effects, which is the reason many choose to stop medicating. Researchers at Lund University in Sweden have now identified biomarkers that can show in advance how the patient will respond to metformin treat

https://www.lunduniversity.lu.se/article/metformin-type-2-diabetes-patients-or-not-researchers-now-have-answer - 2025-11-23

This thesis investigates the effect of visible articulatory movements on speech comprehension in L1 and L2 listeners of Swedish. Previous research found faciliatory effects on speech perception when speech was presented audiovisually in various settings and under diverse listening conditions for both L1 and L2 listeners. However, it is still not investigated thoroughly, how L2 proficiency affects

Forskning visar att naturupplevelser kan leda till ökat mänskligt välmående. Dessa fördelar är särskilt värdefulla för sjuka och sköra personer, såsom patienter på sjukhus. Genom att analysera planeringsdokument och intervjua relevanta aktörer undersöker denna studie hur naturområden är inkluderade i planeringen av ett framtida sjukhus i Helsingborg, Sverige. Mer specifikt så ger den insikt i hur A growing field of research links natural environments to increased human well-being. These benefits are especially valuable for people in the process of regaining health, for instance those who are in hospitals. Through reviewing planning documents and interviewing key actors, this thesis explores how natural environments are incorporated in the planning of a future hospital in Helsingborg, Swede

This exploratory mixed-methods case study research is guided by the question of what kind of role carbon markets can currently play in crafting a business model to support nature-based solutions of wild grassland carbon sinks in Europe. By developing a carbon offset project for the nature organisation Rewilding Europe, this research engages with and connects the literature on carbon markets and ca

BACKGROUND: Breast-conserving surgery followed by radiotherapy is part of standard treatment for early-stage breast cancer. Hypoxia is common in cancer and may affect the benefit of radiotherapy. Cells adapt to hypoxic stress largely via the transcriptional activity of hypoxia-inducible factor (HIF)-1α. Here, we aim to determine whether tumour HIF-1α-positivity and hypoxic gene-expression signatur

CONTEXT: Heart failure (HF) is associated with symptom exacerbations and risk of mortality after an emergency department (ED) visit. Although emergency physicians (EPs) treat symptoms of HF, often the opportunity to connect with palliative care is missed. The "surprise question" (SQ) "Would you be surprised if this patient died in the next 12 months?" is a simple tool to identify patients at risk

BACKGROUND: Guidelines recommend primary percutaneous coronary intervention (PCI) in patients with ST-segment-elevation myocardial infarction (STEMI) presenting ≥12 hours of symptom onset in the presence of ongoing ischemia. However, data supporting this recommendation are limited. We evaluated the effect of primary PCI on reperfusion success, using cardiac magnetic resonance, in STEMI patients wi

Rationale: Symptom relief is a key treatment goal in patients with chronic obstructive pulmonary disease (COPD). However, there are limited data available on the response to bronchodilator therapy in patients at low risk of exacerbations with different levels of symptom severity. This study compared treatment responses in patients with a range of symptom severities as indicated by baseline COPD as

Daily school physical activity (PA) improves musculoskeletal traits. This study evaluates whether the benefits remain 4 years after the intervention. We followed 45 boys and 36 girls who had had 40 min PA/school day during the nine compulsory school years and 21 boys and 22 girls who had had 60 min PA/school week (reference), with measurements at baseline and 4 years after the program terminated.

Muscle-invasive bladder cancer (MIBC) is characterised by significant molecular heterogeneity, with the tumour composition being further sculptured by local microenvironmental influences. This inherent complexity contributes to the divergent disease trajectories and the variable therapeutic susceptibility observed among patients. Consequently, there is an evident need for prognostic and predictive

BACKGROUND: Experimental research has shown the benefits of auditory white noise on cognitive performance in children with attention problems. However, little is currently known about individual differences in noise response amongst children with a clinical diagnosis of attention deficit hyperactivity disorder (ADHD). In addition, no research has so far tested the effects of visual white noise on

Background Electrical cardioversion of atrial fibrillation is associated with an increased risk of embolic stroke, but is generally considered safe if performed within 48 h after onset. Our objective was to investigate if thromboembolism and bleeding in association with cardioversion of atrial fibrillation differed between patients with and without oral anticoagulation. Methods Retrospective study

BACKGROUND: We sought to identify potential clinical variables associated with outcomes after radium-223 therapy in routine practice. METHODS: Consecutive non-trial mCRPC patients who received ≥1 dose of radium dichloride-223 at four academic and one community urology-specific cancer centers from May 2013 to June 2014 were retrospectively identified. Association of baseline and on-therapy clinical