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In order to identify the signal epitopes of the neuropeptide Y (NPY) molecule, the conformation of the NPY molecule was pertubated by a systematic double D-amino acid replacement of neighbouring residues. These NPY-analogs were examined for receptor affinity and on biological activity. The rat cerebral cortex and hippocampus were used for binding characteristics on Y1 and Y2 binding sites, respect
Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis
Abstract Noroviruses are now the leading cause of gastroenteritis worldwide. Noroviruses are effectively transmitted due to a low infectious dose, viral shedding in high concentrations, environmental stability, and they induce only a limited immunity after infection. Especially, the norovirus variants of genotype II.4 (GII.4) have seemed greatly adapted for pandemic spread. The high infectivity o
The incidence of narcolepsy type 1 (NT1) increased in Sweden following the 2009-2010 mass-vaccination with the influenza Pandemrix-vaccine. NT1 has been associated with Human leukocyte antigen (HLA) DQB1*06:02 but full high-resolution HLA-typing of all loci in vaccine-induced NT1 remains to be done. Therefore, here we performed HLA typing by sequencing HLA-DRB3, DRB4, DRB5, DRB1, DQA1, DQB1, DPA1
Background: Screening that includes digital breast tomosynthesis (DBT) with two-dimensional (2D) synthetic mammography (SM) or standard 2D digital mammography (DM) results in detection of more breast cancers than does screening with DM alone. A decrease in interval breast cancer rates is anticipated but is not reported. Purpose: To compare rates and characteristics of (a) interval breast cancer in
Objective: The aim of this systematic review and meta-analysis (SR-MA) was to identify signaling molecule profiles and blood-derived biomarkers in migraine and cluster headache (CH) patients. Background: Currently no migraine and CH valid biomarkers are available. Blood tests based on biomarker profiles have been used to gather information about the nervous system. Such tests have not yet been est
Rationale & Objective: Data for outcomes of patients with end-stage renal disease (ESRD) secondary to systemic sclerosis (scleroderma) requiring renal replacement therapy (RRT) are limited. We examined the incidence and prevalence of ESRD due to scleroderma in Europe and the outcomes among these patients following initiation of RRT. Study Design: Registry study of incidence and prevalence and
Lung cancer is a common cancer type associated with poor prognosis. Even in the group of patients with earlystage tumors, for which curative treatment is possible, lung cancer recurrence is frequent. The aim of this thesis was to investigate the potential prognostic role of mutations in tumor specimens, blood-based proteins and circulating tumor DNA.In study I, we performed EGFR mutation detection
Objective: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. Methods: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait-specific polygenic risk scores for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol
Faculty of Science 2026 | Lund University 1 Education that equips students to solve the challenges of tomorrow 2 Wide range of programmes and courses Stable student base of around 3,000 students, including 1,800 full-time equivalent students. Broad selection of degree programmes. Large number of freestanding courses. Strong emphasis on practical learning through laboratory work and field studies.
LUNDS UNIVERSITET 1 LUNDS UNIVERSITET KURSPLAN PPTR Institutionen för psykologi Familjeterapi A. PPTR01. Kurs 1: Teoretisk bas (theoretical basis) Nivå A. 7 högskolepoäng Kursen är inrättad av Samhällsvetenskapliga fakultetsstyrelsen 2012-05-03 Kursplanen är fastställd av Institutionsstyrelsen vid Institutionen för psykologi 2012-06-05. Denna kursplan gäller från och med ht 2012. B. Allmänna uppgi
https://www.psy.lu.se/sites/psy.lu.se/files/kursplanfamiljeterapiinriktning2012.pdf - 2026-07-22
Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing cells Review Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing Alessandro Fiorenzano * , Edoardo Sozzi, Malin Parmar and Petter Storm Citation: Fiorenzano, A.; Sozzi, E.; Parmar, M.; Storm, P. Dopamine Neuron D
303413_nr1_Omslag_Chakra.indd Ed ited b y Ish a D u b ey C hakra A rticulations of a Pandem ic 2020 N o 1 SASNET ISBN 978-91-986267-3-5 ISSN 1652-8220 Articulations of a Pandemic Researching and Navigating South Asia in the Times of Covid-19 EDITED BY ISHA DUBEY SASNET | LUND UNIVERSITY Swedish South Asian Studies Network (SASNET) SASNET is an interdisciplinary network for the production and d
https://www.sasnet.lu.se/sites/sasnet.lu.se/files/2021-01/web_version_chakra_2020_no_1_ny-3.pdf - 2026-07-22
Background: Myocardium at risk (MaR) can be evaluated by cardiovascular magnetic resonance (CMR) imaging using contrast-enhanced steady state free precession (CE-SSFP) in patients after ST-elevation myocardial infarction (STEMI). However, CE-SSFP utilizes gadolinium contrast, which is contraindicated in patients with severe renal insufficiency. Native T1-mapping is a non-contrast CMR method which
Background: SARS-CoV-2 remains globally circulating, yet post-pandemic comprehensive molecular, serological, and population-level immunity data from low-resource settings such as Ethiopia are limited. This study employed genomic surveillance with seroepidemiological assessment to characterize the epidemiology of SARS-CoV-2 among individuals presenting with influenza-like illness (ILI) and severe a
Background and objective: Patients diagnosed with grade group (GG) 1 prostate cancer (PCa) following treatment for benign disease (“incidental” PCa) are typically managed with active surveillance (AS). It is not known how their outcomes compare with those observed in patients diagnosed with GG1 on biopsy. We aimed at determining whether long-term oncologic outcomes of AS for patients with GG1 PCa
Importance: Early identification of the likelihood of autism spectrum disorder (ASD) using minimal information is crucial for early diagnosis and intervention, which can affect developmental outcomes. Objective: To develop and validate a machine learning (ML) model for predicting ASD using a minimal set of features from background and medical information and to evaluate the predictors and the util
BACKGROUND: Sacroiliac joint pain is increasingly recognized as a cause of low back pain. We compared the safety and effectiveness of minimally invasive sacroiliac joint arthrodesis using triangular titanium implants and conservative management in patients with chronic sacroiliac joint pain. METHODS: This study was a prospective, multicenter randomized controlled trial of adults with chronic sacro
76 F Å G E L Å R E T 2 0 2 3P R O J E K T LUVRE LUVRE-projektet (Lund Uni- versity Vindel River Expedi- tion) startades 1963. År 2023 var det 61:a verksamhetsåret och alla delprojekt genom- fördes i full omfattning enligt uppgjord plan (med något litet undantag). Fokus ligger på övervakning av och forskning kring fåglar, men även insek- ter, träd och däggdjur med mera studeras i fjällmiljön runt G
https://www.luvre.lu.se/sites/luvre.lu.se/files/2025-01/LUVRE_Fa%CC%8Agela%CC%8Aret2023.pdf - 2026-07-22
GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). METHODS AND RESULTS: A nine-SNP-lipid-genetic-risk-score was r
