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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial lipopolysaccharide (LPS), a driver of hyperinflammation in severe COVID-19. How viral evolution over the years alters this interaction remains unclear. Here, we i

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, insulin resistance, dyslipidemia, and hypertension. Its association with venous thromboembolism (VTE) has been inconsistently reported. We investigated the association between MetS and VTE, and the influence of sex and abdominal obesity. We included 12,788 middle-aged and older adults from the re-ex

Aims: Identifying reliable biomarkers is crucial for addressing diagnostic uncertainty and prognostic stratification in amyotrophic lateral sclerosis (ALS). This systematic review and meta-analysis aimed to integrate recent evidence on blood and cerebrospinal fluid (CSF) biomarkers.Methods: We searched studies published between January 1, 2019, and March 25, 2025, investigating blood or CSF biomar

BACKGROUND: Type 2 diabetes mellitus (T2DM) is common among people with HIV (PWH), although studies comparing T2DM-related complications in people with and without HIV (PWoH) remain limited. This was assessed using data from the Cohort Study on Morbidity and HIV in Sweden (COSMOHS).METHOD: Nationwide study including Swedish residents born 1930-2006, diagnosed with T2DM between 2010 and 2019, follo

Den här broschyren riktar sig till dig som vill veta mer om vad palliativ vård är och vad den kan göra för personer med allvarlig sjukdom eller vid tillstånd då livet är hotat.Palliativ vård fokuserar på livskvalitet och kan starta tidigt i sjukdomsförloppet och pågå parallellt med annan vård. Här får du veta mer om vad palliativ vård är och fördelarna med att påbörja den tidigt, oavsett om det är

What happens when you take a normal city and try to cram more people into it, without expanding the surface on which it can grow? Maybe you end up with something like Manhattan or Tokyo, with skyscrapers standing side by side and large roads cutting in-between them. Now we try to fit some more people in. Then you might get something similar to Hong Kong, more compact, more layered and with even le

Genom Bohuslän, mellan Strömstad och Göteborg, löper en järnväg. En järnväg som heter Bohusbanan. En järnväg som en gång i tiden var en symbol för framtidstro och utveckling. Banans praktfulla stationshus, de första som välkomnar en och den sista som vinkar adjö vid ett besök till en av de många orterna längs järnvägen, står idag som barriärer till samhällena de tillhör. Byggnaderna som en gång vaThrough Bohuslän, between Strömstad and Gothenburg, runs a railway. A railway called Bohusbanan. A railway that was once a symbol of optimism and progress. The line’s grand station buildings—the first to welcome and the last to bid farewell to visitors of the many towns along the route—now stand as barriers to the communities they belong to. Buildings that were once open, public, social spaces own

I Sörmlands sydöstra kustlandskap, på Tunabergshalvön, ligger den lilla bruksorten Buskhyttan. Orten har goda geografiska förutsättningar att utvecklas som en aktiv landsbygdsort, där man kan leva ett liv närmare naturen men ändå ha nära till arbete och stad. Den uppkom i och med etableringen av ett sågverk år 1917, men sedan slutet av 1970-talet har verksamheten varit nedlagd och sågområdet lämnaIn the southeastern coastal landscape of Södermanland, on the Tunaberg Peninsula, lies a small mill town called Buskhyttan. It is strategically placed within its community and has the potential of being a well connected and active rural area where you can live a life closer to nature. The town emerged with the establishment of Marsvikens sawmill in 1917, but since the end of the 1970s the industry

Background: Anaemia is frequently recorded during preoperative screening and has been suggested to affect outcomes after surgery negatively.Objectives: The objectives were to assess the frequency of moderate to severe anaemia and its association with length of hospital stay.Design: Post hoc analysis of the international observational prospective 'Local ASsessment of VEntilatory management during G

Current strategies to reduce the climate impact of production and consumption are insufficient to meet the pressing targets of the Paris Agreement. To expand visions of the possible ‘solution space’ in climate transitions, we explore a framework based on two dichotomies centred around the role of labour and the composition of economic output. From these dichotomies we sketch out four pathways for

Breast cancer is the most common cancer in women. Lymphoedema in the arm is a well-known side effect of breast cancer treatment and ranks high among the serious concerns of survivors. Thus, it is important to diagnose arm lymphoedema at an early stage and start conservative treatment when lymphoedema is still minimal or mild, thereby preventing development or deterioration of arm lymphoedema. Scre

Questions: How did α-, β- and γ- plant diversity of coastal dune slack plant communities change over 37 years during a period of significant changes in conservation management practices?. Location: Ainsdale Sand Dunes National Nature Reserve, England. Methods: We surveyed plant communities in dune slacks at Ainsdale Sand Dunes National Nature Reserve at two time points: in 1985 and in 2022. This p

Digital technology has become an integral aspect of contemporary cities, especially with the rise of smart city initiatives. Over the past two decades, researchers and practitioners have studied the potential of large public screens, also known as urban screens, in transforming public spaces and shaping the urban experience. This article contributes to the debate by discussing urban screens in the

We introduce a two-phase quadratic integrate-and-fire (QIF) neuron whose membrane potential evolves according to two alternating Riccati equations within finite bounds. This simple extension removes the unphysical voltage divergence of the standard QIF model while producing realistic spike waveforms. Despite this modification, the system retains an exact low-dimensional description in the thermody

Sweden is renowned for its centralised wage bargaining system, which has been studied from the point of view of inflation, wage differentials and unemployment. This article studies media coverage of wage bargaining rounds in the 1950s–1960s and in the 2000s–2010s to investigate the social understanding of what the wage bargaining institutions are supposed to do. The results indicate that the opera

The endothelin receptor antagonist atrasentan improved kidney outcomes in the SONAR trial for type 2 diabetes and chronic kidney disease (NCT01858532), though individual responses varied. To identify molecular biomarkers of atrasentan response and outcome, we conducted a nested case-control proteomics study (N = 180) within the SONAR trial population and identified urinary clusterin (uCLU) as the

Introduction: Strengthening Primary Health Care (PHC) is essential for building resilient and equitable health systems, but PHC faces barriers in implementation, resource allocation, and political prioritisation. This study aimed to develop a strategic roadmap to enhance PHC by identifying core values, priorities, and actionable strategies through expert consensus. Methods: A two-round Delphi stud

Globally, a substantial number of children experience various forms of parental maltreatment. Child protection agencies work to support these children and prevent further abuse or neglect, often through targeted interventions directed at the parents. Previous research has indicated that social workers may approach male and female perpetrators of maltreatment differently once a case is reported. To