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Objective: To determine whether combining routine cross-cultural cognitive assessments with plasma phosphorylated tau217 (p-tau217) increases diagnostic accuracy in identifying Alzheimer's disease (AD) in a consecutive mixed memory clinic cohort of ethnically diverse patients. Methods: We included 201 memory clinic patients originating from 42 different countries. Patients were examined with the M

Aggregation of the hyperphosphorylated tau protein is a central driver of Alzheimer’s disease, and its accumulation exhibits a rich spatiotemporal pattern that unfolds during the course of the disease, sequentially progressing through the brain across axonal connections. It is unclear how this spatiotemporal process is orchestrated, namely, to what extent the spread of pathologic tau is governed b

Aqueous redox flow batteries (RFBs) as grid-scale energy storage devices hold great potential to accomodate the rising demand for intermittent renewable energy sources. A significant parameter that enhances the sustainability of RFBs is selecting the appropriate redox species. In this study, we investigated the application of lignosulfonate as a redox species for the negolyte of aqueous RFBs becau

BACKGROUND: Heart failure (HF) is characterized by hemodynamic derangements that are likely to mediate systemic metabolic perturbations but limited data are available. Plasma metabolite profiling provides opportunities for comprehensive investigation of such perturbations. Here, we aimed to characterize plasma profiles that associate with HF and their relationship with central hemodynamics, sympto

Within the stroma of pancreatic ductal adenocarcinoma (PDAC), mesenchymal cells differentiate into cancer-associated fibroblast (CAF) subtypes that differentially mediate disease progression. Defining the regulatory mechanism and diversity of CAF subtypes could identify potential therapeutic strategies to harness the tumor-suppressive activities of CAFs. To address this, we utilized single-cell RN

The Hjortspring boat is the only intact example of a prehistoric sewn plank boat ever found in Scandinavia. Built from lime wood planks lashed together with cordage, the boat represents the maritime technology used by some of Northern Europe’s earliest seafarers. This article reports new analysis of the cordage and caulking material used in the construction of the Hjortspring boat. We provide the

Objectives (1) To assess the risk of haematological malignancies in individuals with systemic sclerosis (SSc) compared with individuals without SSc; (2) to explore how the risk varies across groups stratified by sex and age; and (3) to determine when these malignancies present in relation to SSc diagnosis in a population-based setting. Methods We performed a nationwide cohort study using high-qual

Electronic flat bands associated with quenched kinetic energy and heavy electron mass have attracted great interest for promoting strong electronic correlations and emergent phenomena such as high-temperature charge fractionalization and superconductivity. Intense experimental and theoretical research has been devoted to establishing the rich nontrivial metallic and heavy fermion phases intertwine

Biomass gasification gas (BGG), a carbon-neutral renewable fuel and important hydrogen carrier, holds significant promise for sustainable energy systems. However, its practical implementation is challenged by combustion instability and elevated NOx emissions, primarily due to localized high-temperature zones induced by the hydrogen content. MILD (Moderate or Intense Low-oxygen Dilution) combustion

Measurements of inclusive and differential production cross-sections of a top-quark-top-antiquark pair in association with a W boson (tt¯W) are presented. They are performed by targeting final states with two same-sign or three isolated leptons (electrons or muons) and are based on s = 13 TeV proton-proton collision data with an integrated luminosity of 140 fb−1, recorded from 2015 to 2018 with th

Astra och Sirius går ut för att skåda stjärnornaAstra and Sirius go out stargazing

Astra och Sirius utforskar innre solsystemetAstra and Sirius explore the inner solar system

Three searches for the direct production of τ-sleptons or charginos and neutralinos in final states with at least two hadronically decaying τ-leptons are presented. For chargino and neutralino production, decays via intermediate τ-sleptons or W and h bosons are considered. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 139 fb−1, recorded with the ATLAS de

Astra och Sirius utforskar yttre SolsystemetAstra and Sirius explore the outer solar system

Astra och Sirius utforskar exoplaneterAstra and Sirius explore Exoplanets

BACKGROUND AND OBJECTIVES: Addressing the association between early-changing Alzheimer disease (AD) biomarkers and cognition is essential for characterizing preclinical AD. However, few studies have explored this relationship longitudinally, especially across multiple biomarker modalities. The aim of this study was to evaluate longitudinal associations of multimodal core 1 AD biomarkers with cogni

Objective Individuals with SLE commonly report chest pain or discomfort. We performed cardiovascular magnetic resonance (CMR) to differentiate coronary artery disease (CAD), coronary microvascular dysfunction (CMD), pericarditis and myocarditis in individuals with SLE who presented with chest symptoms. We also assessed the clinical utility of CMR. Methods Adults with SLE were included if reporting

Objectives: Endometriosis and Irritable bowel syndrome (IBS) are two common diseases with overlapping symptomatology, causing confusion and delay in the diagnostic process. The objective of this study was to identify differences between endometriosis and IBS diagnosed according to Rome IV, by comparing sociodemographic factors, lifestyle habits, and gastrointestinal symptoms. Materials and methods