Search results

The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. In a single nucleotide polymorphism (SNP) screen of this locus in a Basque population, rs28385692, a rare coding variant substituting Leu for Pro at position 16 emerged significantly (p = 0.02). This variant is located in the signal peptide (SP) shared by the three secreted protei

Molecularly well-designed proton exchange membranes (PEMs) with a high local concentration of strongly acidic groups have the potential to fulfill the strict requirements for fuel cell operation under high temperature and low humidity. Here, we have prepared a series of well-defined and tunable PEMs based on poly(p-phenylene alkylene) backbones functionalized with sulfonated polypentafluorostyrene

Active vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], plays a pivotal role in calcium homeostasis and bone metabolism. Circulating levels of 1,25(OH)(2)D(3) are thought to be dependent mainly on the activity of the renal cytochrome P450 enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), which is potently induced by PTH. However, 1alpha-hydroxylase activity or expressi

All cells of the musculoskeletal system possess transmembrane syndecan proteoglycans, notably syndecan-4. In fibroblasts it regulates integrin-mediated adhesion to the extracellular matrix. Syndecan-4 null mice have a complex wound repair phenotype while their fibroblasts have reduced focal adhesions and matrix contraction abilities. Signalling through syndecan-4 core protein to the actin cytoskel

More than 100 distinct mutations in the gene (SOD1) for human copper-zinc superoxide dismutase (CuZnSOD) have been associated with familial amyotrophic lateral sclerosis (fALS). Studies of these mutant proteins, which often have been performed under far from physiological conditions, have indicated effects on protein stabilities, catalytic activity, and metal binding affinities but with no common

Under 2015 steg andelen konsumenter som handlat på mobilen från 16 % till hela 42 %. Ökningen kan bero på att hemsidor blir mer mobilanpassade. Trots det finns det fortfarande en del användare som uppfattar det som mindre säkert att handla på mobilen i jämfört med på en dator. Förtroenden för e-handel skapas i flera led, där gränssnittet bara en del som påverkar kundens tillit. Detta projekt gjord

I Sverige finns det idag mellan 400 000 – 500 000 geoenergianläggningar och det uppskattas att nettotillskottet energi från geoenergianläggningar är ungefär 18 – 20 TWh per år. Geoenergianläggningar använder markens översta 300 – 500 metrar för att utvinna värme eller kyla. Vid anläggning av geoenergisystem kan man använda olika borrtekniker, mer eller mindre lämpliga beroende på olika geologiska There are about 400 000 – 500 000 shallow geothermal energy systems in Sweden and every year the net additions of energy from geothermal energy systems are about 18 – 20 TWh. Usually it is the upper 300 – 500 meters of the ground that are used for extracting heat or cold from cored strata. When constructing a shallow geothermal energy system, there are different drilling techniques available for u

Caroline Eliasson Avfall – en av framtidens viktigaste resurser Avfallshanteringen har i både Sverige och EU genomgått stora förändringar de senaste åren. Ny lagstiftning och nya styrmedel har implementerats och gett gott resultat genom att minska mängden avfall som deponeras. Nästa utmaning är att kunna utnyttja materialet i avfallet mer än en gång. För det krävs nya strategier. AvfallshanterThe thesis consists of a description of the waste management in Sweden today, related to a case study at IKEA’s warehouses in Älmhult. Waste is globally one of the most important environmental challenges. Waste management in Sweden has developed a lot during the past years and is now standing in front of the next big challenge: to reach higher up in the waste hierarchy. By studying the academic li

Streptomyces is the largest genus in the phylum Actinobacteria, known for their complex life cycle and secondary metabolite production. The model bacterium Streptomyces coelicolor grows _lamentously by tip extension and hyphal branching. The hyphal tip is highly organised, with various structural proteins forming a large assembly termed the polarisome. An essential protein, DivIVA, localises to th

Till skillnad från effekter förknippat med övergödning och marin plast, är få medvetna om den negativa miljöpåverkan sandmuddring kan ha på de marina ekosystemen. Sandmuddring ger stora förluster i livsmiljö, förändringar i salthalt och ökad grumlighet vilket utgör ett potentiellt hot mot ett stort antal marina och bräckvatten arter. Ännu värre är det faktum att få människor vet att sandutvinning Unlike effects associated with eutrophication and marine plastics, few are aware of the negative environmental impacts sand dredging can have on marine ecosystems. Major habitat losses, changes in salinity and increased turbidity impose a potential threat to a large variety of marine and brackish species. Even worse is the fact that few people know that sand extraction currently is taking place wi

Syfte: Syftet med vår studie är att beskriva och analysera utformning av organisation och styrning av akutkliniker. Det är också att undersöka huruvida specifika arbetssätt utmärker sig och utifrån detta skapa ett underlag för framtida diskussion rörande organisation och styrning av akutsjukvård. Metod: Uppsatsens metod grundar sig i en kvalitativ undersökningsdesign där multipla fallstudier anväPurpose: The purpose of this thesis is to describe and analyze the organization of and control tools used at emergency clinics. Futhermore it aims explore whether any methods are better than others to ease the patients’ process through the organization and create a basis for further discussion. Methodology: The thesis method is based on a qualitative research design where multiple case studies ha

Under hösten 2016 utlystes en sluten arkitekttävling om ett nytt kulturhus Bergsjön. Bergsjön är en stadsdel i utkanten av nord-östra Göteborg. Många upplever området som isolerat från resten staden både fysiskt och socialt. Bebyggelsen, som i stort sett är helt intakt från 60-och 70-talet, speglar de dåvarande idealen och bjuder på såväl möjligheter som utmaningar. Samtidigt ligger stadsdelen i mDuring the fall in 2016 the city of Gothenburg announced a competition for a new house of culture located in Bergsjön. Bergsjön is a district in the north east part of the city. A lot of people view the area as isolated from the rest of the city, both physically and socially. The near intact development from the 60s and 70s, reflect the ideals of the time which means both great possibilities and c

In forest biomass estimations, three dimensional (3D) canopy structure data derived from images captured by unmanned aerial vehicles (UAVs), also known as drones, has shown potential due to the flexibility and cost efficiency of the method. However, little research has been done for its applicability in bioenergy forest. In this study, a method was developed with the purpose of remotely estimating