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Calcitonin gene-related peptide (CGRP) has a key role in the pathophysiology of migraine and is associated with activation of the trigeminovascular system. Recently, CGRP receptor antagonists have been developed with clinical efficacy. The present thesis aimed therefore to investigate the distribution of CGRP and the CGRP receptor in the trigeminovascular system and in parts of the CNS. In the tri
Glioblastoma multiforme (GBM) is the most common brain tumor in adults. It presents an extremely challenging clinical problem, and treatment very frequently fails due to the infiltrative growth, facilitated by extensive angiogenesis and neovascularization. Pericytes constitute an important part of the GBM microvasculature. The contribution of endogenous brain pericytes to the tumor vasculature in
This paper investigates the decision-making processes of mayors on the municipal level in Brandenburg, Germany, to support 100% renewable energy policies as well as the respective key success factors. Three different cases and their specific settings are examined: (1) Turnow-Preilack with Germany's largest solar power plant, (2) Prenzlau, a town claiming the title 'City of Renewable Energy’ and (3
Nucleoside phosphorylases are essential for the salvage and catabolism of nucleotides in bacteria and other organisms, and members of this enzyme superfamily have been of interest for the development of antimicrobial and cancer therapies. The nucleotide phosphorylase superfamily 1 encompasses a number of different enzymes which share a general superfold and catalytic mechanism, while they differ i
Statistical analyses of health effects of air pollution have increasingly used GIS-based covariates for prediction of ambient air quality in "land use" regression models. More recently these spatial regression models have accounted for spatial correlation structure in combining monitoring data with land use covariates. We present a flexible spatio-temporal modeling framework and pragmatic, multi-s
Regional, national and global cities are disproportionately located on small islands and archipelagos. The spatial turn' within island and urban geography increasingly privileges abstract notions of space, yet the prevalence of big cities on small islands suggests that sensitivity to place-specific spatial factors is necessary if we are to understand both islands and the urban. Whereas previous st
Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples in clinical decision-making is highly dependent on their quality and integrity. New procedures that better preserve sample integrity and reduce degradation are being developed to meet the need
A lysimeter method was evaluated for its suitability in gas emission studies by studying the effect of temperature on CO2 emissions (dark respiration) from cultivated peat soils. The study was carried out with organic soils from two locations in Sweden, a typical cultivated fen peat with low pH and high organic matter content (Orke) and a more uncommon fen peat with high pH and low organic matter
This paper investigates how vascular plants affect carbon flow and the formation and emission of the greenhouse gas methane (CH4 ) in an arctic wet tundra ecosystem in NE Greenland. We present a field experiment where we studied, in particular, how species-specific root exudation patterns affect the availability of acetate, a hypothesized precursor of CH4 formation. We found significantly higher a
The root/organic soil concentration ratio; R/S) of 50 cationic mineral elements was related to their ionic properties, including ionic radius (r), ionic charge (z), and ionic potential (z/r or z(2)/r). The materials studied were ectomycorrhizal beech (Fagus sylvatica L.) roots and their almost purely organic soil substrate, the O-horizon (mor; raw humus) of a Podzol in South Sweden, developed in a
This study investigates the genetic structure of an eukaryotic microorganism, the toxic dinoflagellate Alexandrium ostenfeldii, from the Baltic Sea, a geologically young and ecologically marginal brackish water estuary which is predicted to support evolution of distinct, genetically impoverished lineages of marine macroorganisms. Analyses of the internal transcribed spacer (ITS) sequences and Ampl
Motivated by growing considerations of the scale, severity, and risks associated with human exposure to indoor particulate matter, this work reviewed existing literature to: (i) identify state-of-the-art experimental techniques used for personal exposure assessment; (ii) compare exposure levels reported for domestic/school settings in different countries (excluding exposure to environmental tobacc
The diffusion of digital technologies has strongly affected the way scholars and researchers use and perceive the archaeological information detected during the field investigation process. Archaeologists are still only beginning to realize the full potential of these applications beyond the attraction of providing visually engaging documentation and focus on the analytical and interpretive power.
Popular Abstract in Swedish Populärvetenskaplig sammanfattning: (Popularized summary in swedish) I den här avhandlingen har vi studerat bindväven i brosk. Bindväv är ett samlingsnamn för de stödjevävnader som ger form och struktur åt brosk, ben, senor, hud etc. Bindväven skyddar även inre organ från yttre påverkan. Det är bindväven som ger brosket dess speciella egenskaper och som gör att brosketThis thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. Here we show that chondroadherin also have a different exon-intron organization and chromosomal localiz
Highly sensitive biosensors were developed for environmental and medical applications. The biosensors were based on bioengineered proteins as biorecognition elements coupled to a highly sensitive capacitive transducer. Heavy metal binding proteins like the metallothionein SmtA, regulatory protein MerR, periplasmic protein MerP and the synthetic phytochelatin EC20 were used for designing, construc
Introduction: Intraperitoneal adhesions are common after abdominal surgery and may lead to serious clinical complications. Previous studies have investigated the possible effects of the polypeptides poly-L-lysine (αPL) and poly-L-glutamate (PG) forming a polymer complex that prohibits local peritoneal adhesions after surgery. The aim of this study was to examine whether the normal process of perit
