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The field of research dealing with the integration of biomolecules with electronic elements to form functional devices is called ‘‘bioelectronics’’. Bioelectronics based on mediated electron transfer (MET) between the biological element and the electrodes are designated as “second generation” while the one based on direct electron transfer (DET) is specified as “third generation”. Implanted bioele
B cell lymphomas (BCLs) are a group of severe cancers, afflicting both men and women at different ages. Gene expression profiling (GEP), have during the latest decades fundamentally contributed to a better classification and biological understanding of the different BCLs. Most studies using GEP have analyzed mRNA from tumor tissue constituted of both tumor cells and non-malignant bystander cells.
IMPORTANCE Standard dosing of chemotherapy based on body surface area results in marked interpatient variation in pharmacokinetics, toxic effects, and efficacy.Whether tailored dosing can improve outcomes is unknown, as is the role of dose-dense adjuvant chemotherapy. OBJECTIVE To determine whether tailored dose-dense adjuvant chemotherapy improves the outcomes of early breast cancer compared with
The human-environment connection in the mostly rural drylands of sub-Saharan Africa forms a complex, interlinked system that provides ecosystem services. This system is susceptible to climatic variability that impacts the supply of its products, and high population growth, which impacts the demand for these products. When plants remove carbon dioxide from the atmosphere through the process of phot
Amelogenin is an extracellular matrix protein involved in formation of enamel during early tooth development. By interacting with the forming enamel crystallites amelogenin affects their growth, so that highly elongated hydroxyapatite crystals are formed. Early during the enamel formation amelogenin is proteolytically processed, which is essential for correct enamel formation. However, the exact m
Mercury (Hg) is regarded as a major environmental concern in many regions, traditionally because of high concentrations in freshwater fish, and now also because of potential toxic effects on soil microflora. The predominant source of Hg in most watersheds is atmospheric deposition, which has increased 2- to >20-fold over the past centuries. A promising approach for supporting current European effo
Uncertainty in our calculations of a system reveals the limits of our knowledge. This limitation makes model representations of the Earth system challenging and our predictions less reliable. However, despite appearing chaotic and non-linear, a system always follows a deterministic trajectory, which can often be expressed probabilistically. Building on this concept, this thesis applies data assimi
Cancer är en vanlig sjukdom i dagens samhälle, och man estimerar att en av tre i Sverige någon gång i livet kommer få en cancerdiagnos. De stora framsteg som skett inom forskning och teknologi har gjort att man har blivit bättre på att behandla så att allt fler överlever sin sjukdom. Det finns dock studier som tyder på att personer med samma diagnos kan reagera olika på samma typ av behandling. VaPurpose: In an era of personalized oncology where the aim is to give every patient the right treatment at the right time an area of promising research is emerging called radiomics, or quantitative image analysis. The main underlying hypothesis is that pathophysiological information can be found in image texture not visible to the bare eye that can improve diagnosis, treatment adaption or be linked
Från och med 2022 ställer Boverket krav på att klimatpåverkan från nyproducerade byggnader ska redovisas uttryckt i kg koldioxidekvivalenter per kvadratmeter bruttoarea. Den s.k klimatdeklarationen utgår från livscyklisk metodik där produktskedet och byggproduktionsskedet omfattas. I klimatdeklarationen ska även periodiskt underhåll och livslängder för klimatskalet noteras. Många branschaktörer arAs of 2022, the Swedish National Board of Housing, Building and Planning (Boverket) is requiring that the climate impact from newly developed buildings has to be calculated and reported in terms of kg carbon dioxide equivalents per m² of gross area. The so-called climate declaration is based on life-cycle methodology and covers the product stage and the construction process stage. Periodic mainten
Slam från konventionell avloppsvattenrening innehåller näringsämnen samt mullbildande ämnen vilket medför att materialet utgör en resurs som växtnäring och jordförbättringsmedel. Problematiken med att använda slam är att det även innehåller främmande ämnen som metaller och svårnedbrytbara organiska föreningar. Syvab är ett kommunalt bolag som driver Himmerfjärdsverket men ansvarar också för någrSludge is produced in conventional waste water treatment. The sludge contains nutrients and humic formaing substances which make it useful as a fertilizer. The problem with using sludge is that it also contains toxicants as heavy metals and persistent organic compounds. Syvab is a municipal owned corporation that manage the wastewater treatment plant Him-merfjärdsverket. Since August 2010 Himmer
Denna uppsats undersöker vilka möjligheter en privat organisation har att använda sig av personuppgifter utan samtycke på grund av ett så kallat ”berättigat intresse” enligt personuppgiftslagen (1998:204) samt lagen om elektronisk kommunikation (2003:389). Ett berättigat intresse föreligger när behandling av en uppgift är nödvändig för ett ändamål hos den personuppgiftsansvarige eller en tredje paThis thesis examines the possibilities of a private entity to use personal data without consent, based on a so called "legitimate interest" in accordance with the personal information act (1998:204) and the electronic communications act (2003:389). A legitimate interest is in effect when processing of a piece of personal information is necessary for the liable party or a third party with
The use of Penman-Monteith (PM) equation in thermal remote sensing based surface energy balance modeling is not prevalent due to the unavailability of any direct method to integrate thermal data into the PM equation and due to the lack of physical models expressing the surface (or stomatal) and boundary layer conductances (g(S) and g(B)) as a function of surface temperature. Here we demonstrate a
Popular Abstract in Swedish Ökat antal patienter som lider av kärlsjukdomar behandlas idag med interventionella metoder istället för kirurgi. Dessa metoder populärt kallade ballong sprängningar, kombineras numera oftast med inläggande av ett metallnät (stent) som hjälper till med att förstärka kärlväggen, så den inte skall falla ihop efter ballong vidgningen. Oavsett vilken metod som används, kompBackground: Restenosis is the most frequently occurring adverse event after percutaneous intravascular treatment of atherosclerotic lesions, which limits long-term patency of the intervention. Objective: The aim of the study was to evaluate if minimizing vascular injury during treatment by insertion of self-expanding stents or modifying the reparative mechanisms by local drug delivery can reduce r
Popular Abstract in Swedish Östersjön är ett grundhav med tillförsel av saltvatten från havet och sötvatten från omgivande floder. De två vattenmassorna är vertikalt skiktade, vilket resulterar i en estuarin cirkulation, vilken har genomgått stora förändringar till följd av landhöjningen efter senaste nedisningen. För att kunna rekonstruera havsmiljöers förändringar bakåt i tiden är det nödvändigtThe Baltic Sea is a continental shelf sea that is influenced by both river runoff and marine water. The two water masses are vertically stratified in the Baltic Sea, resulting in a positive, estuarine circulation system, which has undergone changes in the past due to isostatic uplift of the Baltic basin. For researchers to understand past changes in the marine environment of the Baltic Sea, a soun
Dactylorhiza majalis subsp. sphagnicola is an allotetraploid marsh orchid derived from parents closely similar to present-day D. incarnata and the western European form of D. maculata subsp. maculata, suggesting that it has a postglacial origin. It extends from northwestern continental Europe into areas formerly covered by the Weichselian ice sheet in mid-Scandinavia. Here, we studied the variatio
Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat deposits from the former crater lake Steregoiu in a mid-altitude area in the Gutaiului Mountains in NW Romania in order to provide a detailed reconstruction of the vegetational development of the area during the Late-Glacial and Holocene. The bottom sediments are siliciclastic and were deposited probably duri
The rise in CDOM (coloured dissloved organic matter) is likely to be relatively more pronounced in remote northern regions. However, there is a lack of monitoring to confirm this. For this reason, there is a strong incentive to develop remote sensing-based methods to map CDOM in lakes across broader geographical scales and to include geograghic contex in such analysis. There is a lack of understan
This research is a case study of the social activism experiences of Ai Xiaoming, a literature professor, feminist, rights activist, and independent documentary filmmaker. The research addresses the broad struggle for recognition and representation of feminists, activists, independent filmmakers, public intellectuals and scholars in digital China. The analysis of her case has led to the creation of
1. In the rat hepatic artery, the acetylcholine-induced relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is abolished by a combination of apamin and charybdotoxin, inhibitors of small (SK(Ca)) and large (BK(Ca)) conductance calcium-sensitive potassium (K)-channels, respectively, but not by each toxin alone. The selective BK(Ca) inhibitor iberiotoxin cannot replace charybdot
