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Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the

Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,

Interactions between metals and natural organic matter (NOM) are of great environmental importance and one of the key factors influencing hydrolysis, solubility, and speciation of the metals. However, studying geochemically relevant metals like Al, Fe, and Cu is sometimes associated with analytical problems; for example Fe and Cu are both redox active. Gallium (Ga) is a non-redox active metal that

Biogenic volatile organic compounds (BVOCs) play an important role in the chemistry of the troposphere, especially in the formation of tropospheric ozone (O3) and secondary organic aerosols (SOA). Ecosystems produce and emit a large number of BVOCs. It is estimated on a global scale that approximately 90% of annual BVOC emissions are from terrestrial sources. In this study, measurements of BVOCs w

The characterization of naturally occurring mutations is one way to approach functionally significant domains of polypeptides. About 10 mutations have been reported in factor XIII (FXIII) A-subunit deficiency, but very little is known about the effects of the mutations on the expression or the structure of this enzyme. In this study, the recent crystallization of FXIII A-subunit and determination

Svensk sammanfattningKraftiga förluster av pollinerare är oroande och det har talats om risken för att en pollineringskris ska uppstå, med konsekvenser för både människor och miljö. De flesta blommande växter och tre av fyra odlade grödor är nämligen insektspollinerade (Box 1). Minskningarna hänger ihop med det moderna jordbrukets utveckling. Många gamla hagmarker och ängsmarker där bin och fjäril

Popular Abstract in Swedish Denna avhandling består av tre olika uppsatser. Den första uppsatsen, Technical Efficiency and Ownership: The Case of Booking Centres on the Swedish Taxi Market” behandlar problemet med konkurrens på lika villkor. Upprinnelsen till uppsatsen var diskussioner mellan privata och offentliga aktörer på den svenska taximarknaden. De privata aktörerna hävdade att de offentligThis thesis consists of three different essays, all of which have arisen from a practical problem. In the first essay, “Technical efficiency and ownership: The case of booking centers in the Swedish Taxi Market” the purpose is to examine the question of competition on an equal basis between privately and publicly owned booking centers in the Swedish taxi market. One way to answer this question is

In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s

Shortcomings of current techniques used for the intracerebral transplantation of ventral mesencephalic dopamine neurons include low graft survival, high variability, considerable implantation trauma and suboptimal graft integration. In order to overcome these limitations, we have adopted a microtransplantation approach which allows precise and reproducible implantation of ventral mesencephalon cel

The work presented in this thesis has aimed to improve the knowledge about the groundwater occurrence in different geological conditions in Mozambique. The main focus in this study has been on the understanding of hydrogeological conditions in area with little background information by use of geophysical investigation. The lack of background information is a problem in many countries because the e

In this thesis I explore the subject on how burial was used by Viking Age population of South-western Scania to express their social identity. As opposed to most earlier research concerning Viking Age burials I utilise regional, mourner-centred and practice-based approach. I am following observations conducted for burials in Denmark by J. Ulriksen (2011), focused on traces of deposition of burned

Currently, policy makers put high attention in supplying global energy demand by focusing on 2°C policy; global temperature anomaly based on the global mean temperature of pre-industrial era (13.7°C). How to keep the 2°C policy at global scope is the main question in climate framework. It is widely believed that primary energy resources (mainly coal, oil and natural gas) with focus on shale gas re

Children affected by the multisystem genetic disorder Hutchinson-Gilford Progeria Syndrome look prematurely aged, suffer from elderly-related conditions and die during adolescence due to cardiovascular complications. The cause of the disease is single point gain-of-function mutations in the LMNA gene, which encodes the lamin A and lamin C proteins, major components of the nuclear lamina. These mut

How will baby fish react to global warming? As most people have been aware of, global warming is just one of many consequences of climate change and increasing CO2-levels in the atmosphere. The oceans are experts at absorbing energy, which makes the ocean temperature rise. In many parts of the world, especially Australia, the sea surface temperatures (SSTs) are increasing rapidly today. This is e

Titel: Placering av europeiskt distributionscentrum för att minska LUL-transporter för företag inom industrin för lagrade alkoholhaltiga drycker Författare: Josefin Berntson, Cecilia Flink Handledare: Sebastian Pashaei, Avdelningen för industriell ekonomi och logistik, Lunds Tekniska Högskola, Lunds universitet. Problembeskrivning: Den ökade efterfrågan av distribution, som ett resultat av den Title: Allocation of a European Distribution Center to Minimize LUL Shipments for Companies within the Aged Alcoholic Beverage Industry Authors: Josefin Berntson, Cecilia Flink Supervisor: Sebastian Pashaei, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: The increased demand for distribution as a result of the globalization has in

Development of environmentally friendly and cost-efficient energy sources has been a challenge for modern society since long ago. Sunlight is an infinite and costless source of energy on Earth, so it would be an enormous advantage to efficiently harvest and transform it into electrical energy used in our everyday life. In nature the process, which converts light energy into chemical energy, is cal

My allotment got me thinking about what wonders nature does to man and our current stressful world we live in. How does the work environment look today and how can we arrange the office to find inspiration and an appetite for knowledge? This led me into the project ”The Working Scene”, the study of the working environments and how we can approve on the office. We are all in some way part of a glo

Stora Enso Nymölla is a pulp and paper mill mainly producing office paper. Their most well-known product is the MultiCopy paper. Every fourth year all large companies are by law required to present an energy audit. This can be done as one large report or by presenting smaller reports during the four-year period. Nymölla Mill has decided to publish short overviewing reports every year and combining