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Popular Abstract in Swedish Forskning om stamceller har fått mycket uppmärksamhet de senaste åren. Mycket av intresset avspeglar möjligheten att använda denna typ av celler som en terapi för att bota olika sjukdomar. En stam cell från hjärnan är en cell som har förmåga att dela sig symmetriskt, varvid två kopior bildas eller asymmetriskt, vilket ger upphov till en ny stam cell samt en progenitorceIn the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). Long-term growth factor-expanded

Popular Abstract in Swedish Inflammatoriska ledsjukdomar, innefattande bl.a. ledgångsreumatism, reumatoid artrit, och ledinflammation vid psoriasis, psoriasisartrit, är vanliga. I västvärlden lider cirka 1 procent av den vuxna befolkningen av reumatoid artrit (RA) medan psoriasisartrit (PsoA) är mindre vanlig. Ett kännetecken för dessa sjukdomar är att de medför en risk att ledernas vävnader brytsThe pathogenesis of inflammatory arthritides include synovial inflammation and joint tissue destruction. Tissue destruction has traditionally been regarded a consequence of inflammation, but recent observations indicate that the processes are not always closely linked and may proceed uncoupled. The ultimate target organs for the destructive process are articular cartilage and bone. This thesis f

Popular Abstract in Swedish Studier av cystatin C's funktion in vitro och in vivo.

In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positiv

Background Exposure to inorganic arsenic increases the risk of cancer and non-malignant diseases. Inefficient arsenic metabolism is a marker for susceptibility to arsenic toxicity. Arsenic may alter gene expression, possibly by altering DNA methylation. Objectives To elucidate the associations between arsenic exposure, gene expression, and DNA methylation in peripheral blood, and the modifying eff

BACKGROUND: Community studies have documented prevalence rates of psychological disorders among older individuals. Further, a growing number of studies have examined depression in older medical patients. However, little is known about the prevalence of a broad range of psychological disorders and psychosocial stressors among older primary care patients. The purpose of the present study was to char

Zebrafish is emerging as a complement to mammals in behavioral studies; however, there is a lack of comparative studies with rodents and humans to establish the zebrafish as a predictive translational model. Here we present a detailed phenotype evaluation of zebrafish larvae, measuring 300-3000 variables and analyzing them using multivariate analysis to identify the most important ones for further

Background and Purpose - Acute stroke patients with unknown time of symptom onset are ineligible for thrombolysis. The diffusion-weighted imaging and fluid-attenuated inversion recovery (FLAIR) mismatch is a reasonable predictor of stroke within 4.5 hours of symptom onset, and its clinical usefulness in selecting patients for thrombolysis is currently being investigated. The accuracy of the visual

Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this study was to examine whether 5 DNA methylation loci in blood DNA (ABCG1, PHOSPHO1, SOCS3, SREBF1, and TXNIP), recently reported to be associated with T2D, migh

BACKGROUND: Aggregate and risk-stratified perioperative mortality rates (POMR) are well-documented in high-income countries where surgical databases are common. In many low-income and middle-income country (LMIC) settings, such data are unavailable, compromising efforts to understand and improve surgical outcomes. We undertook a systematic review to determine how POMR is used and defined in LMICs

microRNAs (miRNAs) are 20-24 nucleotides small, single-stranded, non-coding RNAs. They associate with Argonaute (AGO) proteins and exert their function by inhibition or degradation of messenger RNAs. A single miRNA can target hundreds of genes and one gene can be targeted by several miRNAs, hereby giving rise to a complex post-transcriptional network. In the brain, hundreds of miRNAs are expressed

Sedan mitten på 1900 talet har halvledarmaterial revolutionerat hur vi ser på världen genom uppfinningar som det har gett upphov till, såsom datorer, solceller, och lysdioder. Det är möjligheten att kunna styra halvledarens förmåga att leda ström—mellan att vara nästan metallisk till att vara isolerande—som gör den användbar för tillämpningar inom elektronik. Under de senaste decennierna har elektThis dissertation focus on the atomic-scale characterization of the surface properties and electronic structure of III–V semiconductor nanowires (NWs). Since the early 2000s, the fabrication and characterization of III–V NWs has been a very significant topic within material science due to their potential for applications in lighting, energy harvesting, and electronics. A prominent feature of the N

We used PCR and DNA sequencing to screen for haemosporidian parasites (Haemoproteus and Plasmodium) in 2,488 individual birds from 104 species and 22 families, primarily understory suboscine passerines, captured in a lowland Amazonian forest in Ecuador as a first major step to understanding the transmission dynamics of this cosmopolitan group of parasites in this region. To assess diversity of avi

Purpose: Although advances in Hodgkin lymphoma (HL) treatment have led to improved disease-free survival, this has been accompanied by an increased risk of second cancers. We sought to quantify the second cancer risks and to investigate the impact of family history. Patients and Methods: Using the Swedish Family-Cancer Project Database, we identified 9,522 individuals with primary HL diagnosed bet

Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases re-quires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro dia

The Pleistocene-Holocene transition brought turbulent times to human societies confronted by rapid climatic fluctuations, shifts inbiogeographic zones and the flooding of continental shelves. While the disappearance of Doggerland’s inhabited landscapes underthe grey waters of the North Sea marks the culmination of these changes for European Archaeologists, our aim is this paper is todraw parallels

Objectives: The purpose of this study was to develop a procedure to investigate the occurrence, character and causes of magnetic resonance (MR) imaging incidents. Methods: A semi-structured questionnaire was developed containing details such as safety zones, examination complexity, staff MR knowledge, staff categories, and implementation of EU directive 2013/35. We focused on formally reported inc

This audio paper draws on analysis of a case study within the field of artistic research. In summer 2018, the project sent poet Gunnar D. Hansson, composer Anders Hultqvist and ecological sound artists Stefan Östersjö and Halla Steinunn Stefánsdóttir on a search for the sounds of the book Tapeshavet (Hansson, 2017). The work links to the author’s Activation Series, which employs the artistic metho