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We have previously shown that porcine aortic endothelial cells expressing the Y934F platelet-derived growth factor (PDGF) beta-receptor mutant respond to PDGF-BB in a chemotaxis assay at about 100-fold lower concentration than do wild-type PDGF beta-receptor-expressing cells (Hansen, K., Johnell, M., Siegbahn, A. , Rorsman, C., Engstrom, U., Wernstedt, C., Heldin, C.-H., and Ronnstrand, L. (1996)

Popular Abstract in Swedish Under 9 år (1989-1997) studerades individuellt märkta mindre hackspettar i ett undersökningsområde i södra Smålands ädellövskogar. De flesta studierna gjordes i 17 potentiella revir, vilka undersöktes årligen. Följningar av hackspettar försedda med radiosändare visade att fåglarna rörde sig inom ett, i medeltal, 742 ha stort hemområde under vintern. Under häckningstideOver 9 years, 116 breeding attempts made by individually marked lesser spotted woodpeckers (Dendrocopos minor) were followed in a study area in southern Sweden. The home-range area decreased from on average 742 ha in winter to a defended territory of 103 ha prior to breeding and 43 ha during nesting. The annual timing of the breeding varied between years but was each year synchronized with the bu

This thesis presents two new technologies, SIRE technology based biosensors and magneto immunoassays, which can be used for bioanalytical applications. One of the main problems associated with biosensor technology is the instability of the recognition element since it is of biological origin and thus, has a limited lifetime. Conventionally, this problem has been solved by immobilizing the biologic

Technology transfer is important to understand how knowledge is transformed to economic value. Applying a case study approach, this thesis investigates the technology transfer efforts from the University of Dar Es Salaam to indigenous informal SMEs in Tanzania and examines the impact of one of their technology transfer mechanisms on the specific technological capabilities that were acquired at the

New anti-inflammatory drugs with fewer adverse effects than existing drugs may prove to be useful in the treatment of several inflammatory disorders. A critical step in acute inflammation is the infiltration of neutrophils into tissues. Therefore, molecules that target and inhibit this early inflammatory event are attractive to engineer to suit medical needs. The Chemotaxis Inhibitory Protein of

During peritoneal dialysis (PD), a major portion of the osmotically induced water transport to the peritoneum can be predicted to occur through endothelial water-selective channels. Aquaporin-1 (AQP-1) has recently been recognized as the molecular correlate to such channels. Aquaporins can be inhibited by mercurials. In the present study, HgCl2 was applied locally to the peritoneal cavity in rats

MORC2 (Microorchidia CW type Zinc Finger protein 2) is a GHKL (gyrase, heat shock protein 90, histidine kinase, MutL) ATPase involved in chromatin remodeling and is highly conserved in eukaryotes. Mutations in the ATPase domain of MORC2 are known to cause neurodevelopmental disorders. MORC2 is recruited by the HUSH complex to target long, intronless transcription units such as LINE-1 retrotranspos

Background: Estrogen receptor alpha (ERα) is a protein that belongs to the nuclear receptor family. It is regulating the expression of genes involved in cell cycle progression, proliferation, and apoptosis. Approximately 75% of breast cancers express ERα, making it an important target for treatment. Researchers have identified various isoforms of ERα, with the most well-characterized one being a 6

This thesis investigates how AI-generated music challenges traditional systems of cultural legitimacy, identity, and musical taste. Drawing on Bourdieu’s theory of cultural fields and symbolic capital, and supplemented by Simon Frith’s insights into authenticity and identity performance, the study examines how emerging technologies reconfigure creative authority within platform-driven environments

Volcanic eruptions can have severe societal and environmental impacts as shown by ash dispersal and sulphur emissions from recent Icelandic eruptions. However, ice-core sulphur records demonstrate that these events were minor as compared to eruptions of much larger magnitude in recent centuries, with severe implications for past society documented in historical records. Biological and chemical evi

There is a global concern about the decline of wild pollinators and the ecosystem services they provide. Although land-use change is a major threat to biodiversity, it is still poorly understood how land-use heterogeneity (or land-use structure) impacts pollinator communities and entomophilous crop production. Based on a literature review, we performed a meta-analysis to (1) assess how landscape s

Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based

This study constitutes a preliminary survey within the project "Lake and groundwater paleohydrology of the Vomb plain, southern Sweden, for quantitative paleoclimatic calibration". The aim of the study is to describe the Holocene sediment stratigraphy of the former lakes Fönesjön and Kalvsjön (Kalvs mosse), and furthermore to describe and date stratgraphical indications of climatically c

Det kommunala planmonopolet tillåter våra kommuner att reglera mark- och vattenanvändningen samt hur bebyggelsen ska se ut. Detta innebär en stor frihet för kommunens sida men även ett stort ansvar att hantera bygglovsansökningar på ett ansvarsfullt sätt. Det är viktigt att kommunen på ett korrekt och legitimt sätt tar hänsyn till de lagar och regler som en bygglovsprövning innefattar. Åtgärden soMunicipalities have a planning monopoly that allows them to regulate land and water use. With this follows a responsibility to handle building permits in a responsible manner. The building measure must abide by the detailed development plan. Sometimes the building measure deviates from the plan, in such cases the Building committee of the municipality can grant a building permit with a minor devia

I uppsatsen du har framför dig undersöker jag målsägandens ansvar i förhål-lande till en tilltalads uppsåt eller oaktsamhet avseende målsägandens ofrivil-liga deltagande i en sexuell handling. Vi befinner oss alltså i de två första pa-ragraferna av brottsbalkens sjätte kapitel, 6:1 och 6:1 a BrB. Min undersök-ning kretsar dock inte framförallt kring gällande rätt utan kring hovrätternas tillämpninThis essay investigates whether the law or its practice can be said to impose on the plaintiff a responsibility in relation to the defendant’s intent or negli-gence regarding the plaintiff’s involuntary partaking in a sexual act with the defendant. We are hence located in the first two paragraphs of the sixth chap-ter in the Swedish criminal code, 6:1 and 6:1 a Brottsbalk (1962:700). My essay does

TRPA1, är en smärtreceptor på cellmembran vilken aktiveras av skadliga kemiska ämnen, som t.ex. allylisotiocyanater från senap, pepparrot och wasabi och därav kallas TRPA1 även för wasabi-receptorn. Smärta och klåda är tydliga symptom på högre aktivitet hos receptorn. Malariamyggan (Anopheles gambiae), använder denna receptor för att känna av skillnader i miljötemperaturer och receptorn spelar därAnimals monitor environmental ques by translating them into electrical signals through a depolarization of the electric potential over the cell membrane of nerve cells. A way to initiate the depolarization is through activation of receptors that are ion channels. These channels can facilitate the diffusion ions across membranes driven by the differences in concentration and electrical charge on ea

The influence of different drivers on changes in North American and European boreal forests biomass burning (BB) during the Holocene was investigated based on the following hypotheses: land use was important only in the southernmost regions, while elsewhere climate was the main driver modulated by changes in fuel type. BB was reconstructed by means of 88 sedimentary charcoal records divided into s

BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin. METHODS We compared the efficacy and safety of rivaroxaban (at a daily dose of 15 mg) with aspirin (at a daily dose of 100 mg) for th

BACKGROUND: Population-based data on subsequent neoplasms after women are diagnosed with endometrial and ovarian carcinomas are limited, particularly regarding specific histologic tumor types.METHODS: The nationwide Swedish Family-Cancer Database of 10.2 million individuals, which includes 19,128 invasive endometrial carcinomas and 19,440 ovarian carcinomas, was used to calculate standardized inci