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The cone snail is the only invertebrate system in which the vitamin K-dependent carboxylase (or gamma-carboxylase) and its product gamma-carboxyglutamic acid (Gla) have been identified. It remains the sole source of structural information of invertebrate gamma-carboxylase substrates. Four novel Gla-containing peptides were purified from the venom of Conus textile and characterized using biochemica
Silver birch and common oak are known to be sensitive to standard practices in nurseries and they often show poor establishment when transplanted in urban areas. Lifting date and time in cold storage have a strong influence on stress tolerance and plant vitality. This study was carried out to assess the effect of lifting date and storage time on partial photosynthesis measured by chlorophyll fluor
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined this relationship in European cohorts comprising altogether almost 22,000 subjects, in the framework of a European collaborative project (CancerRiskBiomarkers). The present paper gives an overview of some of the results of
The aim of the present study was to analyse quantitatively, on a cat gastrocnemius preparation in vivo, the effects of i.a. or i.v. administered glyceryl trinitrate (GTN), sodium nitroprusside (SNP) or nitric oxide (NO dissolved in saline) on vascular resistance (tone) in the following consecutive vascular sections: Large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 micr
Popular Abstract in Swedish Våtmarker är en naturtyp som man finner i övergångszoner mellan land och vatten. Idag talas det mycket om våtmarkers positiva natur- och miljövärden i avrinningsområden i det moderna jordbrukslandskapet. Våtmarker ger omväxling i landskapet och är viktiga biotoper för växter och djur. I våtmarker ansamlas mycket dött växtmaterial och tillsammans med en god tillgång på vIn this thesis, I have studied nitrogen turnover processes in watermeadows. A watermeadow is a wetland where water infiltrates through the soil of a grassland field. It is hypothesized that infiltration of water through the soil matrix promotes nutrient transformations compared to surface flow of water, by increasing the contact between water, nutrients, soil organic matter and bacteria. I have st
Study Design. Biomechanical analysis of the movement of the lumbar spinal nerve roots (NRs). Objectives. The characteristics of the movement of lumbar spinal NRs corresponding to the change of posture were three-dimensionally analyzed in nonsimulated and simulated adhesion conditions using a porcine model. Summary of Background Data. There is a paucity of data on the movement of NRs. Materials and
The pine sawfly, Diprion jingyuanensis Xiao et Zhang, is a serious pest of Chinese pine (Pinus tabulaeformis Carr.) in the northern parts of China. The general biology of this recently described sawfly species is little known and in the present study we used a synthetic pheromone to monitor its flight period and to evaluate the possibility to use pheromone traps as a tool for estimating and predic
Invariant NKT cells (iNKT cells) are characterized by a semi-invariant TCR comprising an invariant a-chain paired with beta-chains with limited BV gene usage which are specific for complexes of CD1d and glycolipid Ags like a-galactosylceramide (a-GalCer). iNKT cells can be visualized with a-GalCer-loaded CD1d tetramers, and the binding of mouse CD1d tetramers to mouse as well as to human iNKT cell
Testicular germ cell tumours (TGCT) exhibit remarkable ability to differentiate into virtually all somatic tissue types. In this study, we investigated changes in mucin-type O-glycosylation, which have been associated with somatic cell differentiation and cancer. Expression profile of simple mucin-type O-glycans (Tn, sialyl-Tn, T), histo-blood group H and A variants and six polypeptide Ga1NAc-tran
Dynamic models complement existing time series of observations and static critical load calculations by simulating past and future development of chemistry in forest and lake ecosystems. They are used for dynamic assessment of the acidification and to produce target load functions, that describe what combinations of nitrogen and sulfur emission reductions are needed to achieve a chemical or biolog
Popular Abstract in Swedish Det mesta av det genetiska materialet i en eukaryot cell finns samlat till kärnan och är organiserat i kromosomer. Varje gång en cell delas kopieras kromosomerna så att de båda resulterande cellerna får ett bibehållet kromosomantal. Den mekanism som styr denna replikeringsprocess förmår dock inte kopiera de yttersta kromosomändarna, vilket resulterar i att dessa blir koTelomeres are specialized complexes of DNA and proteins that cap and confer stability to the ends of eukaryotic chromosomes. The telomeric DNA of most eukaryotes is composed of tandemly arranged short repeats. Within the budding yeasts these repeats are diverged in length as well as in nucleotide composition. However, they contain a sequence resembling the consensus binding sequence of the major t
Popular Abstract in Swedish Denna avhandling visar att jordgubbar innehåller ett allergen, proteinet Fra a 1, som är mycket likt det allergen som orsakar besvär vid björkpollen-allergi. Den som får allergiska besvär av jordgubbar, t.ex. att det kliar och blir irriterat i munhålan och svalget när man äter , har ofta en björkpollen-allergi sen tidigare. Motsvarande allergen finns också i en del andrStrawberry (Fragaria ananassa) is an economically important crop, and recognised as an important source of antioxidants and bioactive compounds with health promoting effects. Yet increased incidence of allergy puts a limit to the choice of food for an increasing percentage of the population. As part of this thesis a strawberry allergen termed Fra a 1 was identified, which is related to a major bi
Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf
The neural correspondence between the systems responsible for the execution and recognition of actions has been suggested both in humans and non-human primates. Apart from being a key region of this visuo-motor observation-execution matching (OEM) system, the human inferior frontal gyrus (IFG) is also important for speech production. The functional overlap of visuo-motor OEM and speech, together w
