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‘Modern astronomy’ was introduced to Siam (present-day Thailand) when the Belgian Jesuit missionary-astronomer Father Antoine Thomas carried out astronomical observations in 1681 and 1682 in order to determine the latitude and longitude of Ayutthaya. Three years later a contingent of French Jesuit missionary astronomers observed a total lunar eclipse from Lop Buri, which marked the start of an int
Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of
Background: Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes (T1D), but potential underlying mechanisms remain unexplored. We evaluated whether COVID-19 or influenza A infection is characterized by differential DNA methylation at immune and T1D susceptibility genes in young children at risk for T1D. Methods: Epigenome-wide association analysis using t
Gross primary production (GPP) of the vegetation is the largest carbon exchange process of the global carbon cycle. Currently, within satellite-based remote sensing, GPP is generally modelled using linear light use efficiency models where GPP is related to photosynthetically active radiation absorbed by the green vegetation (APAR). These models work well on moderate to low spatiotemporal averaging
The increased demand, driven by a growing population and changing dietary habits, has created immense pressure on agroecosystems throughout the globe. In semi-arid areas, this increased pressure has led to excessive use of agrochemicals in agriculture, which poses a threat of potentially toxic metal (PTM) contamination in agricultural soils. PTMs in agricultural soils result in significant environ
More than 21 million tons of cheese whey are produced annually worldwide, posing an environmental risk if not properly managed. Due to widespread lactose intolerance, cheese whey, which contains lactose, can pose health problems for many individuals. Thus, the management of the cheese whey is necessary to avoid environmental and health problems. This study presents a sustainable approach for whey
Background: A wrist-worn wearable device for acquiring limb and chest ECG leads (wECG) may constitute a promising approach to detection of acute myocardial infarction (AMI). However, it remains to be demonstrated whether the information conveyed by the wECG is sufficient for AMI detection. Objective: To explore explainable machine learning models for detecting AMI using the wECG. Methods: Two type
In recent years, the environmental impact of warfare has made front-page news. Discussions about “ecocide”—a term first proposed in 1970 by Yale biologist Arthur W. Galston to describe the large-scale destruction of ecosystems during the Vietnam War—have come into the spotlight. The preparation and conduct of war, along with the social, economic, and scientific reorganisation that accompany it, of
The Velika Vrbica loess-palaeosol sequence, situated on the south-western bank of the Danube River in northeastern Serbia, represents one of the key Quaternary records in the lower Danube basin, covering the MIS 5-MIS 1 period. Previous investigations of the upper 500 cm established a high-resolution chronology and revealed unexpected patterns of dust accumulation during interstadial phases. In th
Volatile organic compounds (VOCs) include many types of organic compounds, such as alkanes, olefins, aldehydes, etc. They have attracted widespread attention in various fields such as food and flavor analysis, environmental and atmospheric research, safety, or healthcare. Developing efficient, practical, and high-value industrial VOC utilization technologies is crucial for sustainable social and h
Pancreatic polypeptide (PP) is a gut-derived hormone of the neuropeptide Y family that regulates appetite, gastrointestinal motility, and energy homeostasis through activation of the neuropeptide Y4 receptor (Y4R). With the rising prevalence of obesity, understanding the molecular pharmacology and structure-function relationships of PP-Y4R interactions is essential for the development of novel ant
Abstract in UndeterminedBackground The role of allergy in the aetiopathogenesis of chronic rhinosinusitis (CRS) remains controversial. For example, in some cases with sinus fungal infections allergy can be demonstrated by standard tests. In other cases, such signs can be absent despite elevated levels of IgE-positive cells in sinus tissue and the presence of IgE and eosinophils in the sinus mucous
Abstract in UndeterminedStrategic recollection refers to control processes that allow the retrieval of information that is relevant for a specific situation. These processes can be studied in memory exclusion tasks, which require the retrieval of particular kinds of episodic information. In the current study, we investigated strategic recollection in reality monitoring by event-related potentials
Hemophilia patients with inhibitors against FVIII/FIX present with a major challenge in the clinical practice. In the 1970s such patients were treated in association with emergency situations and essential surgery using huge amounts of FVIII/FIX concentrates often preceded by extracorporal adsorption of antibodies against FVIII/FIX. However, moderate to mild bleedings were not effectively treated.
This work proposes methodologies using a model-based approach to gain knowledge on and assist the development of an ion-exchange step in a protein purification process; the separation of IgG from a mixture containing IgG, insulin and transferrin. This approach is suitable for capture and intermediate steps in a process. Both methods involve four consecutive steps. Firstly, the retention of the dif
Popular Abstract in Swedish Biotisk och abiotisk stress hos mikroorganismer och växter.Various forms of stress, such as biotic and abiotic stress, were studied in microorganisms and plants to learn more about the underlying mechanisms of such stress and potential genetic engineering strategies towards stress tolerance. An antifreeze protein from winter flounder, expressed in E. coli, was subjected to directed evolution with NaCl as selective pressure. The resulting clones were teste
Popular Abstract in Swedish När en organism utsätts för stress, t. ex. vid hög temperatur, starkt solljus, torka eller köld, produceras särskilda hjälpar-proteiner, s. k. ¨stress-proteiner¨. Syntesen av cellens normala proteiner stängs av och istället produceras bara stress-proteiner. Dessa stress-proteiner är till för att skydda andra protein som skadas under stress. De s. k. ¨värme-stress¨ proteA specific group of heat shock proteins, the so called small heat shock proteins (sHsps), exists in all organisms but are especially abundant in plants. The sHsps prevent aggregation of other proteins (substrate proteins) during transient heat and oxidative stress. Molten globule forms of the substrate proteins are kept in a re-folding competent state by binding onto the outer surface of the sHsp.
