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Background: Six different N-terminal amyloid precursor protein (APP) fragments, with molecular weight ∼12 kDa, have previously been identified in human cerebrospinal fluid (CSF). In a pilot study, both the sum of their concentrations, measured by western blot, and the relative abundance pattern, measured by mass spectrometry, were different in Alzheimer's disease (AD) patients compared to healthy
Semi-arid regions play an increasingly important role as a sink within the global carbon (C) cycle and is the main biome driving inter-annual variability in carbon dioxide (CO2) uptake by terrestrial ecosystems. This indicates the need for detailed studies of spatiotemporal variability in C cycling for semi-arid ecosystems. We have synthesized data on the land-atmosphere exchange of CO2 measured w
Directed differentiation of human induced pluripotent stem cells (iPSCs) into retinal pigmented epithelium (RPE) holds great promise in cell replacement therapy for patients suffering from degenerative eye diseases, including age-related macular degeneration (AMD). In this study, we generated iPSCs from human dermal fibroblasts (HDFs) by electroporation with episomal plasmid vectors encoding OCT4,
The budding yeast Naumovozyma castellii (syn. Saccharomyces castellii) has been included in comparative genomics studies, functional analyses of centromere DNA elements, and was shown to possess beneficial traits for telomere biology research. To provide useful tools for molecular genetic approaches, we produced stable haploid heterothallic strains from an early ancestral strain derived from the N
In a population-based, matched case-control study from the South Swedish Health Care Region, which has the highest risk for melanoma in Sweden, the relation between the use of sunbeds or sunlamps and malignant melanoma was investigated. Between July 1, 1988, and June 30, 1990, a total of 400 melanoma patients and 640 healthy controls aged 15-75 years answered a comprehensive questionnaire containi
Whole-tree harvesting, i.e. harvesting of stems, branches and tops, has become increasingly common during recent decades due to the increased demand for renewable energy. Whole-tree harvesting leads to an increase in base cation losses from the ecosystem, which can counteract recovery from acidification. An increase in weathering rates due to higher temperatures is sometimes suggested as a process
Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an
Objective: To systematically evaluate the ability of the CINA® LVO software to detect large vessel occlusions eligible for mechanical thrombectomy on CTA using conventional neuroradiological assessment as gold standard. Methods: Retrospectively, two hundred consecutive patients referred for a brain CTA and two hundred patients that had been subject for endovascular thrombectomy, with an accessible
Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit
Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level
Background: Few individuals with alcohol use disorders receive treatment. Primary care has been suggested as an arena for early treatment for these disorders. Aim: To evaluate whether the presence of a specialized addiction nurse can increase alcohol-related physician consultations in a primary care setting. Method: This controlled intervention study included one intervention and one control prima
Group A Streptococcus (GAS)causes infections ranging from mild sore throats to severe invasive disease; however, no licensed vaccine is currently available. In this thesis, the author leverages streptolysin O (SLO), an important GAS protein and therapeutic/vaccine target, as a model system to develop a multimodal protein mass spectrometry(MS) strategy. Through an integrated approach of MS-based pr
Many studies have underscored the impacts of drought on ecosystems, and some researchers reported the effects of accumulated soil moisture deficit (ASMD) on light use efficiency (LUE) in grassland. However, the potential effects of ASMD on gross primary productivity (GPP) and LUE for both cropland and forest ecosystems are still not understood. This study elucidated the effects of accumulated and
Aims: Increased common carotid artery (CCA) intima media thickness (cIMT) is a well-known risk factor for cardiovascular morbidity and mortality. cIMT thickening has been described in patients with repaired aortic coarctation (CoA), but data on mechanism and clinical relevance in this population are scarce. Our aim was to gain mechanistic insights into cIMT thickening of patients with repaired CoA
Widespread autumn cooling occurred in the northern hemisphere (NH) during the period 2004-2018, primarily due to the strengthening of the Pacific Decadal Oscillation and Siberian High. Yet, while there has been considerable focus on the warming impacts, the effects of natural cooling on autumn leaf senescence and plant productivity have been largely overlooked. This gap in knowledge hinders our un
Background: The tumoricidal complex alpha1-oleate targets bladder cancer cells, triggering rapid, apoptosis-like tumor cell death. Clinical effects of alpha1-oleate were recently observed in patients with non-muscle invasive bladder cancer (NMIBC), using a randomized, placebo-controlled study protocol. Aims: To investigate if there are dose-dependent effects of alpha1-oleate. Materials and Methods
The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic tyrosine kinases, contains Src homology domains (SH2 and SH3), and catalytic kinase domain. SH3 domains are important for the targeting of signal
