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Popular Abstract in Swedish När en organism utsätts för stress, t. ex. vid hög temperatur, starkt solljus, torka eller köld, produceras särskilda hjälpar-proteiner, s. k. ¨stress-proteiner¨. Syntesen av cellens normala proteiner stängs av och istället produceras bara stress-proteiner. Dessa stress-proteiner är till för att skydda andra protein som skadas under stress. De s. k. ¨värme-stress¨ proteA specific group of heat shock proteins, the so called small heat shock proteins (sHsps), exists in all organisms but are especially abundant in plants. The sHsps prevent aggregation of other proteins (substrate proteins) during transient heat and oxidative stress. Molten globule forms of the substrate proteins are kept in a re-folding competent state by binding onto the outer surface of the sHsp.

Exaggerated acidosis due to preischemic hyperglycemia shortens the maturation time for cell death and turns selective neuronal damage into pannecrosis. Some issues concerning the mechanisms are yet to be clarified. The present study was designed to define critical thresholds of plasma glucose, to investigate the influence of preischemic hyperglycemia on ion transients, to evaluate the role of calc

BACKGROUND: According to the World Health Organization (WHO) the cost of adverse drug reactions (ADRs) in the general population is high and under-reporting by health professionals is a well-recognized problem. Another way to increase ADR reporting is to let the consumers themselves report directly to the authorities. In Sweden it is mandatory for prescribers to report serious ADRs to the Medical

ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

Every year about 15 million people are injured in traffic, 500,000 of these fatally. Developing countries are badly affected. During the worst years of the war in Nicaragua, more people died in traffic accidents than as a direct result of the war. Transport system and infrastructure have developed rapidly in developing countries, while little has been achieved in preventing accidents or lessening

While several scholars do not consider the anointing of (the feet of) Jesus in Bethany described in the Gospel of John to carry any messianic connotations, some claim that a royal messianic notion is behind the anointing. The hypothesis of this paper is that the anointing is indeed to be understood as messianic, but that it is insufficient to consider only one Christological motif to be in the bac

Popular Abstract in Swedish Salmonella infektion drabbar ca 16 miljoner människor i världen per år. Salmonella sprids genom mat och vatten och fšrekommer främst i länder där god hygien är ett problem. Beroende på vilken typ av Salmonella som man infekteras av, kan man drabbas av magsjuka eller en allvarlig systemisk infektion som i värsta fall kan leda till döden (tyfoid feber). Salmonella tar sigThe immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. Salmonella typhimurium infection in mice is a frequently used model for studying systemic Salmonella infection. O

EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. We have developed a screening method using proteins arrays and validation of targets with surface plasmon resonance. With have applie

Flexible manufacturing puts high demands on industrial automation in terms of affordable and competitive solutions and is of key importance for short-lot production typically found in small and medium sized enterprises, situations where today manual labour is extensively used despite environmental issues and harsh working conditions. Key factors in the successful introduction of new robot automati

One of the common tools for studying the deformation behavior of the microstructure in polycrystalline materials is crystal plasticity models. These are used to describe texture evolution and hardening due to crystallographic slip. A drawback when using crystal plasticity models is that the calculation of the slip requires solving a set of stiff differential equations for each grain in the microst

It’s been 34 years ago now since the iron curtain has parted the European continent and its inhabitants in an East and a West. The analysed area for the following thesis on the border between northern Austria and southern Czechia gives a case example of a region, that is still suffering from an era, where one sky-direction has been erased from people’s everyday living and thinking – leaving the bo

With the climate change and urbanization process, the frequency of the urban flooding’s occurrence has increased in the recent years. It brings great economic losses to the cities, especially to the basements of individual properties. Low Impact Development (LID), which currently advocated by more city planners for managing stormwater, is considered as a more sustainable way to mitigate urban floo

Friedriech's ataxia is a serious neurological condition that is caused by a deficiency in the expression of the protein frataxin. This deficiency is caused by an extension of GAA repeats in the first intron of the frataxin-coding gene. The disease can have an onset as early as five years and by the time the patient has reached 20 years they often require a wheelchair and help to be able to hav

Aims Methadone and buprenorphine diversion by patients in opioid substitution treatment (OST) is a poorly understood phenomenon. We study the norms and attitudes on diversion among OST patients, including the role these norms and attitudes play as diversion risk factors. We also study whether perceived quality of care, social bonds to treatment staff, and deterrence can be associated with diversio

Background: Opioid substitution treatment (OST) with methadone or buprenorphine is the most effective means of treating opioid dependence. If these substances are used by people who are not undergoing OST, they can however carry serious risks. This article examines the lifetime prevalence, motives, and drug sources for such use, as well as geographical differences in these variables. Methods: Stru

A part of the project of transforming the worn down medieval fortress Glimmingehus into a tourist attraction for the people of the 20th century, was to dig out the once filled in moat surrounding it. This very labour intensive project did not only result in a nostalgic atmosphere but also a large amount of fairly well preserved finds, since the moat had once been used as a rubbish dump. A part of

This study looks at the change of the Urban Heat Island (UHI) intensity in Rio Park, Madrid, which during the course of the last 20 years has in essence been retransformed from an urban highway into a flourishing green park along the Manzanares river. The deconstruction of the M-30 highway started in 2005, was completely finished in 2015, and canopy growth in the area continued during the followin

Drainage of peatlands causes changes in water table (WT), vegetation and decomposer community. As a consequence, decomposition patterns and carbon dynamics change, which is visible in altered Dissolved Organic Carbon (DOC) concentrations in ground and soil water. Additional changes in precipitation patterns towards more extreme drought and rain periods, as expected with climate change, cause furth