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Seasonal dynamics of haemosporidian (Apicomplexa, Haemosporida) parasites in house sparrows Passer domesticus at four European sites : comparison between lineages and the importance of screening methods

Infectious diseases often vary seasonally in a predictable manner, and seasonality may be responsible for geographical differences in prevalence. In temperate regions, vector-borne parasites such as malaria are expected to evolve lower virulence and a time-varying strategy to invest more in transmission when vectors are available. A previous model of seasonal variation of avian malaria described a

The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions

Multifunctional proteins, which play a critical role in many biological processes, have typically evolved through the recruitment of different domains that have the required functional diversity. Thus the different activities displayed by these proteins are mediated by spatially distinct domains, consistent with the specific chemical requirements of each activity. Indeed, current evolutionary theo

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Majorana sweet spots in three-site Kitaev chains

Minimal Kitaev chains, composed of two quantum dots connected via a superconductor, have emerged as an attractive platform to realize Majorana bound states (MBSs). These excitations exist when the ground state is degenerate. The additional requirement of isolating the MBS wave functions further restricts the parameter space to discrete sweet spots. While scaling up to Kitaev chains with more than

Spatiotemporal photon distribution control on active sites enables bio-inspired methane-to-methanol conversion

Direct catalytic conversion of methane to methanol offers a pathway for transforming a potent greenhouse gas into a portable clean liquid fuel, thereby mitigating carbon emissions and supporting sustainable energy. However, this process faces challenges from thermodynamically favorable methanol overoxidation. Here, we show that spatiotemporal regulation of photogenerated charge carriers on enginee