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Background Endometrial adenocarcinoma (womb cancer) is a malignant growth of the lining (endometrium) of the womb (uterus). It is distinct from sarcomas (tumours of the uterine muscle). Survival depends the risk of microscopic metastases after surgery. Adjuvant (postoperative) chemotherapy improves survival from some other adenocarcinomas, and there is evidence that endometrial cancer is sensitive
Popular Abstract in Swedish Mer än hälften av alla kvinnor har haft en urinvägsinfektion. Infektionen uppkommer när bakterier når urinblåsan och börjar växa. Immunförsvaret känner igen bakterierna, reagerar med en inflammation och symptom som sveda, trängningar och smärtor i nedre magtrakten uppstår. Om bakterierna klättrar upp till njurarna sprider sig inflammationen dit och orsakar ryggsmärtor o
Vehicle design is characterized by a high number of compromises. The special role of human factors in the process is to ensure that the compromises do not occur at the expense of the driver and passengers. Within the automotive industry there is a need for the development of inexpensive and efficient ergonomic tools, facilitating a fast and cost effective car development process as well as discuss
Recent investigations of the DNA interactions with cationic surfactants and catanionic Mixtures are reviewed. Several techniques have been used such as fluorescence microscopy, dynamic light scattering, electron microscopy, and Monte Carlo simulations. The conformational behaviour of large DNA molecules in the presence of cationic surfactant was followed by fluorescence microscopy and also by dyna
Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin
The Proton Exchange Membrane (PEM) fuel cell has been investigated for a long time, and is regarded as a new energy source for various applications, such as portable, stationary and automotive ones. However, due to the shortage of the infrastructure in the society, the high cost, the difficulty of the water/thermal management, etc., practical systems have not reached the general public, yet. Of t
Popular Abstract in Swedish Denna avhandling består av tre olika uppsatser. Den första uppsatsen, Technical Efficiency and Ownership: The Case of Booking Centres on the Swedish Taxi Market” behandlar problemet med konkurrens på lika villkor. Upprinnelsen till uppsatsen var diskussioner mellan privata och offentliga aktörer på den svenska taximarknaden. De privata aktörerna hävdade att de offentligThis thesis consists of three different essays, all of which have arisen from a practical problem. In the first essay, “Technical efficiency and ownership: The case of booking centers in the Swedish Taxi Market” the purpose is to examine the question of competition on an equal basis between privately and publicly owned booking centers in the Swedish taxi market. One way to answer this question is
In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. A detailed conformational study of a cyclic p
Popular Abstract in Swedish Med hackspettsögon: att förstå habitatval, revirkvalitet och reproduktionsbeslut utifrån individers beteende Min doktorsavhandling bygger både på teoretiska modeller och på fältstudier av mindre hackspett (Dendrocopos minor). För att slippa språkliga krumbukter eller tvetydigheter kommer jag hädanefter att kalla arten "småspett" i denna sammanfattning. Fältstudierna gjIn this thesis I present some connections between foraging behaviour and reproductive success, time budget, tree species use, and habitat selection. The thesis is based upon both theoretical and empirical work. All empirical studies concern a south Swedish population of lesser spotted woodpeckers Dendrocopos minor, studied between 1990 and 1996. The foraging behaviour of the lesser spotted woodpe
Construction in rock is associated with risks because knowledge of the geology and ground conditions is limited. Unforeseen rock conditions involve a large risk to the project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the c
Load problems in electricity markets occur both on the supply and demand side and can have technical, economic and even political causes. Commonly, such problems have been solved by expanding production and/or distribution capacity, importing electricity or by load management. Load management is a techno-economic measure for harmonizing the relations between supply and demand sides, optimizing pow
Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the
Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,
Interactions between metals and natural organic matter (NOM) are of great environmental importance and one of the key factors influencing hydrolysis, solubility, and speciation of the metals. However, studying geochemically relevant metals like Al, Fe, and Cu is sometimes associated with analytical problems; for example Fe and Cu are both redox active. Gallium (Ga) is a non-redox active metal that
The objective of this thesis is to investigate the synthesis of well-defined polymer nanohybrid materials bearing desirable functionality via surface-initiated atom transfer radical polymerization (SI-ATRP) for potential bioapplications.SI-ATRP is an excellent controlled radical polymerization (CRP) method for the synthesis of polymer nanohybrid by growing polymer brushes (chains) from an interfac
Att planera lokal och regional kollektivtrafik i så kallade ’starka stråk’ – det vill säga att koncentrera infrastruktur och resurser till ett antal färre, men attraktivare stråk i en stad eller en region – är ett standardförfarande i samtida kollektivtrafikplanering. Så har inte alltid varit fallet dock. Denna avhandling visar hur organiseringen av beslutsfattande, planeringspraktiker och den rumPlanning local and regional public transport in so-called ’transit corridors’ – i.e., to concentrate infrastructure and resources to few, but more attractive corridors in a city or a region – is commonplace in contemporary public transport planning. This has not always been the case, however. In this thesis I analyze how transit corridors have come to dominate the policies and planning practices o
The discovery of the CRISPR-Cas9 system has revolutionized several areas of biological research by making genome engineering easy, affordable, fast, accessible and scalable. One field that has not yet benefited from this technological advance is that of mitochondrial DNA research. Study I addresses the challenges associated with adapting CRISPR-Cas9 to the mitochondrial environment, and identifies
Background: Optimal follow-up (FU) strategy to detect potentially curable (PC) recurrences after treatment of localised clear cell renal cell carcinoma (ccRCC) is unclear. This study retrospectively analysed a large international database to determine recurrence patterns and overall survival (OS), as part of a wider project to issue recommendations on FU protocols. Objective: To analyse associatio
