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Brachytherapy for Pediatric Patients at Gustave Roussy Cancer Campus : A Model of International Cooperation for Highly Specialized Treatments

Purpose: Childhood cancer is rare, and treatment is frequently associated with long-term morbidity. Disparities in survival and long-term side effects encourage the establishment of networks to increase access to complex organ-conservative strategies, such as brachytherapy. We report our experience of an international cooperation model in childhood cancers. Methods and Materials: We examined the o

Savouring the sea: Production and consumption of future seaweed foods

Current food systems pose one of the greatest health and environmental challenges of the21st century. A systemic shift in the food sector can be accelerated by technologies and innovations,such as seaweed food applications. However, introducing and expanding seaweed as a food resourceinto Western markets comes with several challenges.These challenges include its microbial, chemical, and sensory qu

To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis : HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Background: Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year

Transnasal Evaporative Cooling in Out-of-Hospital Cardiac Arrest Patients to Initiate Hypothermia—A Substudy of the Target Temperature Management 2 (TTM2) Randomized Trial

Background: In animal models, early initiation of therapeutic cooling, intra-arrest, or restored circulation has been shown to be neuroprotective shortly after cardiac arrest. We aimed to assess the feasibility and cooling efficacy of transnasal evaporative cooling, initiated as early as possible after hospital arrival in patients randomized to cooling in the TTM2 trial. Methods: This study took t

Multiscale pollen-based reconstructions of anthropogenic land-cover change in Karula Upland, south Estonia

Pollen-based quantitative vegetation reconstructions using multiple sedimentary basins from the same area, along with their quantified relevant pollen source areas, are a powerful means to study how long-term human impact has affected vegetation and shaped the currently protected heritage landscapes at different spatial scales. Our study presents the outcome of a palynological investigation in Kar

Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis

Introduction: High-inflammation subgroups of patients with psychosis demonstrate cognitive deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C-reactive protein may alter functional connectivity within and between resting-state networks, but the cognitive and clinical implications of these alterations remain unknown. We aim to determine the relationships of ele

Polycyclic aromatic hydrocarbons (PAHs) in men and lactating women in Slovenia : Results of the first national human biomonitoring

In the first national human biomonitoring study in the Slovenian population of adults (18–49 years), including men (n = 297) and lactating primiparous women (n = 304), exposure to polycyclic aromatic hydrocarbons (PAHs) was evaluated. Nine urinary metabolites of four parent PAHs were determined. These included 1-hydroxypyrene (1-OHPYR), 2-hydroxynaphthalene (2-OHNAP), 2-hydroxyphenanthrene (2-OHPH

Lecticans in Vascular Remodeling of the Pulmonary and Fetal Circulation : Implications for Children with End-Stage Heart Disease

Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular

Falls Predict Fractures Independently of FRAX Probability : A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study

Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted

Integrated approach to investigate groundwater nitrate nitrogen pollution and remediation simulation in Shimabara Peninsula, Nagasaki, Japan

Groundwater is the general source of drinking water in the Shimabara Peninsula, Nagasaki, Japan, and consequently, occurring nitrate nitrogen (NO3-N) pollution in the groundwater is a significant problem. Although various countermeasures have been implemented, nitrate nitrogen concentrations remain serious. Therefore, it is necessary to evaluate effects of different potentially effective counterme

Applying lean principles during ramp-up of high technology goods - A case study at Axis Communication AB

Bakgrund: Under de senaste åren har Axis Communications vuxit fram som världsledande gällande både försäljning och produktutveckling på marknaden för digitala övervakningskameror. Hög innovationstakt och ökande volymer gör det till en utmaning att bibehålla Axis kärnvärde om hög kvalité. För att hitta och lösa kvalitetsproblem tidigt förläggs all initial produktion av en ny produkt till konfiguratBackground: Leading the way in developing digital surveillance camera systems Axis Communications has experienced remarkable growth during the last decade and is now considered the industry leader. Maintaining the core value of high quality is challenging with ever-increasing volumes and a high rate of new product introductions. To find and resolve issues with new products, and ensure a smooth tra

Att upptäcka eller utesluta brott - En undersökning av brister i förfarandet vid polisiära dödsfallsutredningar

Vid dödsfall som har eller kan ha orsakats av yttre påverkan genom skada eller förgiftning har Polismyndigheten i uppgift att konstatera eller utesluta misstanke om brott. För dessa syften utförs en dödsfallsutredning. Dödsfallsutredning är en särskild undersökningsform, vars underlag kan ligga till grund för beslut att inleda förundersökning. Polismyndigheten har vid flera tillfällen fått utstå kIn cases of deaths that have or may have been caused by another person through injury or poisoning, the police authority is obliged to detect or exclude suspicion of crime. To fulfill these purposes, a death investigation is performed. Death investigations are a special form enquiry that may precede a decision to initiate a preliminary investigation. On several occasions, the police authority has

En pollenanalytisk studie av råhumusprofiler från Säröhalvön i norra Halland

Populärvetenskaplig sammanfattning: Särö Västerskog och Särö Nordanskog i norra Halland utgör de mest värdefulla och artrikaste skogsbestånden längs hela västkusten. De är klassade som riksintresse för naturvården. Den biologiska mångfalden är mycket stor och i skogarna förekommer många sällsynta och rödlistade arter. Som exempel kan nämnas den sällsynta idegranen (Taxus baccata). Särö täcks av reThe aim of this study was to make a pollenanalytical investigation of mor humus-profiles from the peninsula of Särö in northern Halland. The coastal forests are well preserved in this area and often hold a very interesting flora and fauna with many red-listed species. One can for example mention the rare species yew (Taxus baccata). The forests contain a mixture of deciduous and coniferous trees l

Hyperlänken till det förflutna : tre nationalarkivs digitala lärmiljöer

The archival sector of today is geared towards the public more than ever before. Students are now expected to actively participate in a process of life-long learning, to be more conscious about their cultural heritage and to develop an awareness of history. They shall also be able to evaluate different kinds of sources and approach source material critically. The Anglo-Saxon archives are internati

Storage period optimization of a viscous nasal spray suspension

The number of people suffering from the unpleasant symptoms of allergic rhinitis is increasing due to environmental and other factors. This not only makes life difficult for the individual but also places a heavy burden on society, which is why treatment is needed. Rhinocort® is a nasal spray suspension manufactured by McNeil AB to reduce the severity of symptoms, and like all medicines, must und