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Background: Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been shown to affect the epigenome in whole blood, pancreatic islets, and adipose tissue in humans, and genome-wide DNA methylation studies have linked epigenetic ch
Hemicelluloses are a group of abundant polymers found in all plants and constitute about one third of the total plant biomass. These polymers can be used in many different products, such as oxygen barrier films, emulsifiers, foams and probiotic food additives. However, the commercial development and use of new products utilizing hemicelluloses has been limited due to the high production cost. Incr
Background: Squamous cell cancer of the anus (SCCA) is a rare malignancy, but the incidence is increasing. It isassociated with humman papilloma virus infection. The standard treatment is radiotherapy (RT) combined withchemotherapy, usually 5-fluorouracil (5FU)/Mitomycin C (MMC). This treatment is relatively effective, butrecurrence still represents a problem especially in locally advanced SCCA.Th
The GHG-CCI project is one of several projects of the European Space Agency's (ESA) Climate Change Initiative (CCI). The goal of the CCI is to generate and deliver data sets of various satellite-derived Essential Climate Variables (ECVs) in line with GCOS (Global Climate Observing System) requirements. The "ECV Greenhouse Gases" (ECV GHG) is the global distribution of important climate relevant ga
Droplet microfluidics has emerged as a promising platform for miniaturisation of biological assays on-chip. In droplet microfluidics small water droplets (nL-pL) surrounded by an immiscible carrier oil are generated at high throughput. In these droplets particles such as cells or microbeads can be encapsulated, and the idea is that each of these droplets can be used as small reaction chambers for
Concerns regarding environmental issues have led to increasing efforts for investigating sustainable production routes for the future industry that is based on renewable resources. Among the biobased chemicals, the C3-chemicals 3-hydroxypropionaldehyde (3-HPA), 1,3-propanediol (1,3-PDO) and 3-hydroxypropionic acid (3-HP), have been identified as top candidates for the chemical industry. Lactobacil
Context. Streaming instability is a key mechanism in planet formation, clustering pebbles into planetesimals with the help of self-gravity. It is triggered at a particular disk location where the local volume density of solids exceeds that of the gas. After their formation, planetesimals can grow into protoplanets by feeding from other planetesimals in the birth ring as well as by accreting inward
Nature-based solutions (NBS) focus on the material functioning of ecosystems as part of a transformative response to societal challenges. NBS represent a growing response to climate change with a range of interventions emerging across the world to address the causes and effects of climate change. The adoption of NBS is claimed to address a range of Sustainable Development Goals, including empowerm
Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and
The ability of intrahippocampal grafts of fetal septal-diagonal band tissue, rich in developing cholinergic neurons, to ameliorate cognitive impairments induced by bilateral fimbria-fornix transections in rats was examined in three experiments using the Morris water-maze to test different aspects of spatial memory. Experiment 1. Rats with fimbriafornix lesions received either septal cell suspensio
Importance: Nonsuicidal self-injury is prevalent in adolescence and associated with adverse clinical outcomes. Effective interventions that are brief, transportable, and scalable are lacking. Objective: To test the hypotheses that an internet-delivered emotion regulation individual therapy for adolescents delivered adjunctive to treatment as usual is superior to treatment as usual only in reducing
Consumer research has a long tradition of examining the limits of consumer society (e.g. Schor & Holt, 2000). Overconsumption refers to a harmful and excessive type of consumption practice, which is typical of contemporary consumerism (Kjellberg, 2008). In the past, overconsumption was used synonymously with more theoretical concept such as hyper-consumption (Kilbourne et al., 1997) and afflue
BACKGROUND: A comprehensive overview of treatments of common fractures is missing, although it would be important for shared decision-making in clinical practice. The aim was to determine benefits and harms of surgical compared to non-surgical treatments for traumatic skeletal fractures. METHODS: We searched Medline, Embase, CINAHL, Web of Science, and CENTRAL until November 2018, for randomized t
Objective: Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVneo) was exposed to various concentrations of PM2.5 (PM2.5) in order to elucidate the effect of urban
We know now that discs of gas and dust, so-called protoplanetary discs, form planets as side-products of the naturally occurring star formation process throughout the Milky Way. Young, growing planets in such discs are commonly referred to as protoplanets. In about 10\% of the so-far observed stars, this planet formation process leads to the occurrence of giant planets, such as Saturn, Jupiter, or
Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with t
The purpose of this thesis is to evaluate and deduce the varied lifeways of Early Holocene foragers in southern Scandinavia. By taking an interdisciplinary approach, zooarchaeological data have been applied to the study of different aspects of Early and Middle Mesolithic subsistence, in order to frame a discussion concerning our current understanding of culture and life in early north European soc
Visst vore det fint om vi kunde producera nödvändiga kemikalier mer effektivt, förse alla människor med de läkemedel de behöver till en lägre kostnad än vad som är möjligt idag, och förhindra översvämningar i stadsmiljö? Men vad har dessa tre ting gemensamt, egentligen? Jo, att man kan optimera de olika processer som ligger bakom alla tre! Processer finns i princip överallt i världen, komplexa som eComplex processes can be seen as a series of actions, changes, and/or events that are related in different temporospatial manners, and thus are potentially difficult to understand. Optimizing such a process is therefore not necessarily a simple feat, and doing it experimentally may become both time-consuming and expensive. Computer-aided optimization therefore lends itself as a viable alternative,
