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Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to organisms. The detailed mechanism of this enzyme is currently not known, and computational studies are complicated by the fact that different density functional theory (DFT) methods give very different energetic results for calculations involving nitrogenase models. Recently, we designed a [Fe(SH)4H]

Fibril-reinforced poroviscoelastic material models are considered state-of-the-art in modeling articular cartilage biomechanics. Yet, cartilage material parameters are often based on bovine tissue properties in computational knee joint models, although bovine properties are distinctly different from those of humans. Thus, we aimed to investigate how cartilage mechanical responses are affected in t

Herein, we present the synthesis of two new dicobaloxime complexes, [{ClCo(dmgH)2(4-PyCOO)}2Zn(DMF)2] (1) and [{ClCo(dmgH)2(4-PyCOO)}2Cd(H2O)3(DMF)].4H2O (2) bridged by isonicotinate-Zn(ii) and Cd(ii) moieties. These complexes were synthesized upon reaction of a monomeric chlorocobaloxime [ClCo(dmgH)2(4-PyCOOH)] with Zn(NO3)2·6H2O and Cd(OAc)2·2H2O in a methanol/DMF solvent mixture. Both complexes

Monitoring available feed for livestock is a key factor for developing pastoralism in the Sahel, and satellite images has proven useful in monitoring dry mass on large spatial scales. This approach requires field measurements of dry mass (herbaceous and woody plants) to calibrate such models based on Earth observation data. However, the need for representative field measurements can be a challenge

Background: Despite improvements in hemophilia care, challenges remain, including treatment burden and impaired quality of life. Gene therapy may overcome these. However, its introduction presents a challenge. Objectives: To outline a function-based gene therapy working model describing critical milestones associated with gene therapy handling, administration, and follow-up to facilitate and imple

AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga

BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H

Landscape-scale land use is important in driving species communities and interactions. However, despite increasing concerns regarding the ecological consequences of insect declines, our understanding of how the relative proportions of different land cover types influence insect herbivory in species-rich semi-natural habitats remains limited. This study assessed leaf, stem, and flower herbivory acr

The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in GSIS using isolated murine islets. Additionally, the significance of extracellular NO on GSIS was studied. Islets incubated at basal glucose showed modes

In the aftermath of the Covid-19 pandemic, the accelerated shift to remote and hybrid work modes has left many office buildings vacant. Meanwhile, many cities struggle with providing housing. Adaptive reuse (AR) is the process of giving an existing building a new life, typically through an extensive renovation and refurbishment. Residential adaptative reuse specifically refers to adapting for hous

Microorganisms have unique biochemical mechanisms to inhibit the growth or kill other microorganisms in the same environment. Bacterial threat agents (BTA) are more effective than conventional weapons because of these characteristics, therefore, the development and production of biological weapons are still relevant. Early warning signals need to be obtained for fast and accurate detection of BTA

Pool boiling is an effective heat dissipation approach in electronic cooling, battery thermal management, etc. This study used the electrochemical deposition method to fabricate one smooth nickel specimen (named Ni-smooth) and three specimens with a porous nickel-stacked structure. The three porous specimens were created with deposition current densities of 0.5 A·cm–2 (named Ni-0.5), 2.0 A·cm–2 (n

A peptide corresponding to a 13-residue segment of the human protein semenogelin I has been shown to generate a hydrogel consisting of amyloid-like fibrils. The relative chemical diversity (compared to synthetic de novo sequences) with 11 distinct amino acids makes this peptide (P0) an ideal candidate for investigating the role of individual residues in gelation. Herein, the N-terminal residues ha

Crystallization-induced stress within confined spaces of porous materials presents significant challenges across various disciplines, including conservation science, geomorphology, geotechnical engineering, and concrete durability. Despite its significance, understanding how localized, transient, and anisotropic stress is generated in pores due to salt crystallization, along with its mechanisms of

Residents of the Sahel depend on livestock, but harsh environmental conditions during the dry season limit rangeland forage, which is the main source of livestock feed. Al-though operational tools exist for assessing and monitoring forage quantity during the dry season, assessments of forage quality are lacking. We addressed this gap by developing satellite-based monitoring of forage quality acros

A clear understanding of the mechanisms governing the growth of nanowires is crucial to achieving control over their structures and properties. Here, we employ molecular dynamics (MD) simulations to investigate several important phenomena in Au-catalyzed Si nanowires (SiNWs) grown via the vapor–liquid–solid method. MD simulation serves as a complementary tool for uncovering the mechanisms of nanow

This thesis offers a cultural analysis of climate change, modernisation and sustainable development in the pastoral landscape of Baringo, Northern Kenya. For the majority of the pastoralists living there, life is defined by crippling poverty, ethnic violence and an increasingly erratic and unpredictable climate. In response, a growing number of people have moved away from the traditional reliance

OBJECTIVE: This study evaluated the effects of a 6-week osteoarthritis (OA) exercise and education intervention on metabolic health markers, including blood pressure (BP), glycated haemoglobin (HbA1c), high-density lipoprotein (HDL), cholesterol levels and weight in individuals with both OA and diabetes.METHODS: Data originated from the Swedish Osteoarthritis and Diabetes cohort, which is composed

High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale

Vegetation optical depth (VOD) from satellite passive microwave sensors has enabled monitoring of aboveground biomass carbon dynamics by building a relationship with static carbon maps over space and then applying this relationship to VOD time series. However, uncertainty in this relationship arises from changes in water stress, as VOD is mainly determined by vegetation water content, which varies