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Linear epitopes of bony fish β-parvalbumins

Introduction: Fish β-parvalbumins are common targets of allergy-causing immunity. The nature of antibody responses to such allergens determines the biological outcome following exposure to fish. Specific epitopes on these allergens recognised by antibodies are incompletely characterised. Methods: High-content peptide microarrays offer a solution to the identification of linear epitopes recognised

Free-Energy Landscape and Rate Estimation of the Aromatic Ring Flips in Basic Pancreatic Trypsin Inhibitors Using Metadynamics

Aromatic side chains (phenylalanine and tyrosine) of a protein flip by 180° around the Cβ-Cγ axis (χ2 dihedral of the side chain), producing two symmetry-equivalent states. The study of ring flip dynamics with nuclear magnetic resonance (NMR) experiments helps to understand local conformational fluctuations. Ring flips are categorized as slow (milliseconds and onward) or fast (nanoseconds to near

What happens if we put it on-screen? : Exploring students’ perception of and interaction with representations, feedback, and characters in virtual learning environments

Samhällets storskaliga digitalisering har inte bara påverkat människors vardag och yrkesliv, den har också påverkat undervisning och lärande på ett genomgripande plan – inte minst när det gäller det kunskapsbyggande som tar plats i skolor och klassrum, under ledning av lärare. Under de senaste decennierna har pappersbaserat material och laborationsutrustning ersatts av applikationer och digitala vThis thesis is about learning. It is about how younger students (6–12 years old) usethings on-screen (representations, feedback, or virtual characters) and how they handle digitalised learning environments. I have explored this subject using many perspectives and theories, not only focusing on handheld tools and physical or virtual materials, but also on the social interactions behind the screens,

Glycated Albumin Percentage is Correlated With HbA1c : Theoretic Marker in Patients With Altered Erythrocyte Turnover

INTRODUCTION: The gold standard for monitoring long-term glucose levels in patients with diabetes mellitus is glycated hemoglobin (HbA1c). In conditions where the erythrocyte half-life is decreased, for example, in long-term kidney diseases and hemoglobinopathies, HbA1C may underestimate the long-term glucose exposure. Therefore, in these patient groups, other methods to monitor long-term glucose

Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays

Edoxaban is an oral direct factor Xa inhibitor for prophylaxis and treatment of thromboembolic disorders. The effects on common coagulation assays are clinically valuable information and in certain clinical situations a quick assessment of the anticoagulant is wanted. Our aim was to investigate the effect of edoxaban on routine coagulation methods and evaluate anti-Xa assays, commonly used for oth

Use of non-benzodiazepine hypnotics is associated with falls in nursing home residents : a longitudinal cohort study

BACKGROUND: Falls and related injuries are common among older people, and several drug classes are considered to increase fall risk.AIMS: This study aimed to investigate the association between the use of certain drug classes and falls in older nursing home residents in Sweden, and relate these to different age groups.METHODS: Information on falls that occurred in the previous year and regular use

Predictive Control of Irrigation Channels

The aim of this project is to make a predictive controller of a part of an irrigation channel. The channel is called ``The Haughton Main Channel'' (HMC) and is situated in Queensland. Irrigation channels are used by farmers all around the year and it is important that they deliver water on demand. The project has been made in cooperation with the Department of Electrical and Electronic Eng

Sevesorapport för ny verksamhet - Hur man upprättar en säkerhetsrapport när anläggningen är i planeringsstadiet

To reduce the risk of serious chemical accidents to occur there is a legislation called the Seveso-legislation. One part of this legislation demands that all business that handle certain amounts of chemical compounds to submit a safety report in order to get permission to run their business. The safety report should contain over-all plans of how to handle safety as well as detailed descriptions o

Löneunderlagsregeln och kapitalandelskravet

3:12-reglerna, är beteckning på den samling bestämmelser som reglerar hur stor del av avkastningen delägaren får realisera i inkomstslaget kapital. Utan särregleringen skulle en delägare kunna undvika den progressiva skatten för förvärvsinkomster genom att ta ut förvärvsinkomsten så som utdelning. Genom att fastställa ett gränsbelopp bestäms utrymmet som kan beskattas som kapitalinkomst. I beräkniThe 3:12-rules regulates the proportion of income that a shareholder in a close company is able to tax as capital income. A shareholder in a close company would be able to avoid the progressive tax on earned income if no special regulation existed. By levying earned income as dividends progressive taxation would be avoided. An established threshold determines the amount that may be taxed as capita

Vem bevisar vad? - En utredning av bevisbördans förhållande till rättssäkerheten i avtalstvister

En ovisshet om ett rättsfaktums existens löser domstolarna oftast med att ena parten åläggs en bevisbörda. Det finns ett antal olika teorier och principer för bevisbördeplacering. När ett rättsfaktum utgörs av ett visst påstått avtalsinnehåll har HD emellertid i vissa fall, utan motivering, använt sig av avtalstolkning istället för en bevisbörderegel. Syftet med förevarande uppsats är därför dels The Swedish courts usually solve uncertainties regarding dispositive facts by using the burden of proof. There is no comprehensive, universal principle that is applicable in all cases; instead there are a number of different theories and principles. When a dispositive fact is made up of a certain alleged contractual content, the Swedish Supreme Court sometimes interprets the contract instead of u

Felaktiga domar, hur är det egentligen med rättssäkerheten?

I Sverige råder principen om fri bevisföring, vilken stadgas i 35 kap. 1 § RB. Detta innebär att det inte finns någon begränsning vare sig gällande de kunskapskällor som får användas för att bevisa det inträffade, eller gällande domarens frihet vid själva värderingen av bevisen. I doktrinen finns olika bevisvärderingsmetoder beskrivna. De som ofta diskuteras är temametoden, värdemetoden samt hypotIn Sweden there is the principle of freedom of evidence, witch is provided in chapter 35. 1 § RB. This means that there is no restriction regarding the sources of knowledge that may be used to prove the incident or regarding the judge's discretion in the evaluation of the evidence. There are various evidence-methods described in the doctrine. The most discussed methods are the method of theme,

Inga Ingenjör

All Swedish citizens have the opportunity to continue their education on a university level. However, children with highly educated parents are far more likely to continue their studies after high school than others. The aim of this project is to inspire children to natural science, innovation and engineering at a young age. This to show what different possibilities the future has to offer, no mat

Performance testing of in silico HLA typing tools using a validated next generation sequencing data set, and identification of HLA allele restricted tumour neo-antigens

Datoranalys av cellernas eget flagg-system kan bidra till forskningen kring patient-anpassade cancerbehandlingar Tänk dig att du zoomar in på cellytan utav dina celler. Något som du kommer lägga märke till är uppradade molekyler med små utstickande protein-stumpar (peptider). De står nästan som flaggstänger med viftande flaggor i olika former. Dessa ”flaggstänger” kallas för MHC molekyler och de

Motives to Stay: Gaining Employee Insights for Designing Talent Retention Strategies

This thesis examines the motives of IT employees to stay employed at their current job in an organisation or resign voluntarily and suggests possible factors for organisations to consider while designing retention strategies. The research was conducted as an inductive case study at an IT organisation headquartered in Sweden. A mixed method approach was adopted to gather empirical data through inte

Bakteriedödande medel i kläder

Biocides are chemical and biological pesticides used for preservation and disinfection. It’s being used, both in health care and everyday life, in products such as hand soap, cosmetics and textile fabrics. Studies have shown that, in textiles, a lot of the quantities of the biocides are being washed out during the life cycle of the product. This study aims to map in what extent biocides are being

Barriärer för elbilsintroduktionen i Sverige - Attityder, ekonomi och teknik

Hur går elbilsintroduktionen i Sverige? Det talas allt mer om elbilar i media och bland politiker. Elon Musk, Tesla:s VD är numera en världskänd visionär, men än ser man inte speciellt många elbilar på vägarna. Så hur går elbilsintroduktionen egentligen i Sverige? I denna uppsats ges en bakgrund till möjligheter och barriärer för introduktionen av elbilar i Sverige, samt var vi är idag. Den svenskThe aim of this study has been to investigate the technical, economical and psychological barriers for the market introduction of battery electric vehicles (BEV) in Sweden. The current situation as well as future possibilities for battery electric vehicles in Sweden has also been central to this study. The study is of a qualitative nature, and is largely based on interviews with experts from the b

Effektiv brottsbekämpning till varje pris – En studie av provokativa åtgärders tillåtlighet och förenlighet med artikel 6 EKMR

Användningen av provokativa åtgärder anses i dagsläget som en godtagbar metod inom ramen för brottsbekämpningen. På grund av åtgärdernas känslighet utifrån integritets- och rättsäkerhetsaspekt används metoden endast i undantagsfall och framförallt för att bekämpa den grova organiserade brottsligheten i Sverige. Syftet med denna uppsats är för det första att utreda rättsläget gällande användningenThe use of provocative investigative measures is an acceptable method within Swedish law enforcement. The method is only used in exceptional cases on the basis of integrity and rule of law and particularly to combat organized crimes in Sweden. The purpose of this paper is firstly to investigate the legal position regarding the use of provocative investigative measures in Sweden and secondly to c

Yang-Mills driven Cosmic Expansion

This thesis will investigate the possibility to have SU(2) gauge fields as the source to the Cosmic Inflation and/or to the Dark Energy. It will be explained that, under certain conditions, the Universe can be filled with vector fields without violating its isotropy. Those conditions are naturally fulfilled within the SU(2) gauge theory. Both Einstein's equations and the equations of motion

Överensstämmer den svenska våldtäktslagstiftningen med Europakonventionen? - En kritisk analys av det svenska förhållningssättet till Europadomstolens dom på sexualbrottsområdet

Den gällande svenska våldtäktsregleringen baseras antingen på tvång eller på otillbörligt utnyttjande vid en särskilt utsatt situation. I begreppet tvång ligger såväl våld som hot, vilka båda enligt den svenska regleringen är lågt ställda krav. ”Särskilt utsatt situation” å andra sidan ser bland annat till vissa exemplifierade situationer. I och med att Europadomstolen avkunnade Bulgariendomen, viThe current Swedish rape law is based on either force or improper use of a “particularly vulnerable situation”. The concept of force includes violence and threat, with levels which are fairly easy to achieve, whilst “particularly vulnerable situation” is exemplified in the law. Since the European Court of Human Rights pronounced the judgment against Bulgaria, requiring the criminalisation of any n

Hur ett trovärdigt miljöarbete skapas inom hotell- och konferensbranschen

The study investigates the difficulties small companies experience in implementing a standardized environmental management system or achieving an Eco-label. Further the study evaluates what should be included in an environmental management system to establish credibility. The market for Eco-labels and certifications has generally been adapted for large companies, but since the environmental awaren