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OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Din semester bidrar till den globala uppvärmningen Avfall är ett växande globalt miljöproblem och en aspekt som orsakar svårigheter är deponering av matavfall som är den tredje största utsläppskällan av metangas i världen. Metangasen kan istället nyttjas som fordonsgas vilket skulle bidra till en minskad användning av fossila bränslen. Därför är en god avfallshantering av största vikt men det ärWaste is a growing environmental problem, especially organic waste that decomposes and generates large emissions of methane. In controlled environments, the methane emissions could instead be used to reduce the use of virgin substances, example fossil fouls. A good waste management is therefore of most importance which sometimes can be difficult to achieve. The waste management is particularly dif

Division of Engineering Logistics The Division of Engineering Logistics offers around 10 courses each year. The concentration starts with the basic Logistics course for Industrial and Mechanical Engineering students. The course is open for additional students if they fulfil the prerequisite course criteria (see course syllabi).Functionally oriented coursesThe Division then offers a number of funct

https://www.ims.lth.se/en/about/engineering-logistics/education - 2026-05-09

Att ängs – och betesmarker ger ett öppet landskap och är trevliga att ströva i är ett av skälen till att bevara dessa marker. Att ängs- och betesmarker är nödvändiga för en stor mängd växter och djur är kanske ännu viktigare. Markerna är trots allt bland de artrikaste landytorna vi har idag. På en äng kan det finnas upp till 50 olika växtarter på bara 1 kvadratmeter och man jämför ibland dessa mar

Ersättning enligt entreprenadavtal utgår i huvudsak som fast ersättning eller enligt löpande räkning. Enligt svensk rätt är entreprenadavtal inte lagreglerade utan istället tillämpas standardavtal. Standardavtalet AB 04 reglerar ersättning enligt löpande räkning genom självkostnadsprincipen som anges i AB 04 kap. 6 § 9-10. Enligt självkostnadsprincipen utgår ersättning enligt en av AB 04 kap. 6 §Construction Contracts are not regulated by Swedish law. Instead, the construction industry uses standard agreements. Construction Contracts usually state that compensation shall be paid as a fixed award or performed on an open account basis. The Swedish standard agreement AB 04 regulates compensation performed on an open account basis in AB 04 chapter 6 paragraphs 9-10. AB 04 chapter 6 paragraph