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Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors
Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro
Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro. We have examined whether such mAbs have detrimental effects on pre-existing cartilage. Bovine cartilage explants were cultured over 21 days in the presence of two arthritogenic mAbs to