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Objective: To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development. Methods: We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs a

IMPORTANCE Treatment trials require sound knowledge on the natural course of disease. OBJECTIVE To assess clinical features, genetic findings, and genotype-phenotype correlations in patients with retinitis pigmentosa (RP) associated with biallelic sequence variations in the PDE6A gene in preparation for a gene supplementation trial. DESIGN, SETTING, AND PARTICIPANTS This prospective, longitudinal,

Introduction: Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between s

Objective: To implement artificial neural network (ANN) algorithms for noninvasive lymph node staging (NILS) to a decision support tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. Methods: The NILS tool is a further development of an ANN prototype for the prediction of nodal status. Training and internal validation of the

Nowadays, strengthening of reinforced concrete structures with a new class of sustainable materials is the possible solution to retrofit the aged deteriorated structures. It is difficult to predict the capacity of the strengthened (FRP/FRCM) reinforced concrete elements without considering the bond strength. Therefore, the concrete substrate to Fibre-Reinforced Cementitious Matrix (FRCM) bond is a

BACKGROUND: Sustained intrauterine hypoxia causes some four million perinatal deaths annually worldwide. The condition is predicated by neonatal acidemia, as determined by pH in umbilical cord blood at birth. We aimed to evaluate the association between umbilical cord arterial pH and long-term outcomes up to 20 years of follow-up.STUDY DESIGN: Using a retrospective cohort design, umbilical cord ar

Monoclinic β-Ga2O3 films grown on c-plane sapphire have been shown to exhibit six (2¯01)-oriented domains, which are equally spaced by rotation around the surface normal and equally sized by volume that render the film optical response effectively uniaxial. We derive and discuss an optical model suitable for ellipsometry data analysis of such films. We model mid- and far-infrared ellipsometry data

Genom freden i Roskilde 1658 kunde Sverige tillskansa sig det tidigare danska Skåne. Fredsavtalet garanterade skåningarna rätten till, bland annat, dansk lag och tidigare danska privilegier. Statens arbete mot uniformitet i provinsen, genom att försvenska området, tog dock sakta men säkert vid, och 1683 var arbetet utfört och uniformiteten införd. Huvudsyftet med uppsatsen har varit att klargöra vIn 1658, the former Danish region of Scania was ceded to Sweden due to the Treaty of Roskilde. The treaty also guaranteed the Scanian population its right to maintain their Danish law and retain their former Danish privileges. Despite this, the state soon started to work towards uniformity between Scania and Sweden by a process known as Swedification, a process which was completed in 1683. The mai

Allergic rhinitis is a common disease affecting millions of people worldwide. Biocare Copenhagen A/S, a Danish biotechnology company decided to screen a number of probiotic lysates, with the aim to identify suitable strains with potential anti-allergic properties, that could regulate production of cytokines and divert the immune system in a regulatory or tolerant mode. People suffering from aller

Three-dimensional (3D) models are widely used within the geosciences to provide scientists with conceptual and quantitative models of the earth’s subsurface. As a result, 3D geologic modelling is a growing field, such that scientific research often cannot keep up with technical advancements. Literature often shows conflicting results with respect to which interpolation algorithms produce the best

Aims. Until recently, most high-resolution spectroscopic studies of the Galactic thin and thick discs were mostly confined to objects in the solar vicinity. Here we aim at enlarging the volume in which individual chemical abundances are used to characterise the thin and thick discs, using the first internal data release of the Gaia-ESO survey (GES iDR1). Methods. We used the spectra of around 2000

Differences between ages, sexes and populations in the timing of migration at Falsterbo, Sweden and in the choice of wintering site among raptors in Scania were investigated. Competition and dominance is the best primary explanation to the results. In most cases the more competitive adults winter north of juveniles and the larger females north of males. Moult strategy is probably one of the most i

Objective To develop an accurate method for quantifying differences in the trabecular structure in the tibial bone between subjects with and without knee osteoarthritis (OA). Methods Standard knee radiographs were taken from 26 subjects (seven women) with meniscectomy and radiographic OA Kellgren & Lawrence grade 2 or worse in the medial compartment. Each case knee was individually matched b

Mixed acid phospholipids are valuable compounds, which are used mainly in membrane- and lipoprotein research and in liposome technology. The chemical synthesis of these special lipids is rather difficult and involves both toxic chemicals and harsh reaction conditions, which makes the products less attractive for medical and biological applications. Enzymes in contrast catalyze chemical reactions u

Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. In the work presented in this thesis, two models were analyzed: hormone-sensitive lipase (HSL) null mice and a pancreatic clonal β-cell line to study the mechanisms underlying insulin resistance and insulin secretion pert

Popular Abstract in Swedish Stroke är en sjukdom som främst drabbar äldre och är den största anledningen till att människor får olika slags handikapp såsom förlamning och afasi. Det finns ännu ingen effektiv behandling för att lindra symtom och lidande efter en stroke, förutom rehabilitering, och därför kostar stroke samhället enormt mycket pengar. Befolkningen blir allt äldre, vilket även medför Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative disorders such as stroke. Stroke is

This thesis addresses the impact of glaucoma on the patients’ vision from both a measurement based and a functionally based perspective. The risk of visual disability is probably the most important question for a newly diagnosed glaucoma patient and maintaining vision-related quality of life (VRQOL) has become the ultimate goal of glaucoma treatment. The objectives of the present thesis were to de

The aim of this thesis was to elucidate developments in epidemiology, clinical manifestations and complications in Chlamydia trachomatis (C.trachomatis) and Mycoplasma genitalium (M.genitalium) infection. In study I the frequencies of non-gonococcal salpingitis, gonococcal salpingitis and ectopic pregnancy (EP) were observed over a period of 28 years and correlated to the prevalence of Neisseria g

This thesis has its focus on the interaction between competition law and the public procurement regime. Since the two systems have the same objective of the creation of an internal market it is vital that the two systems reach coherence. Despite this there is now express provision on the importance to fight anti competitive behaviour in the Public Sector Directive 2004/18/EC. On March 28th 2014 th

Background Supply chains in low margin, high innovation speed industries with strong customers generate a highly competitive environment. The conditions for such environment are continuously changing and put high demands on its actors. FlatFrog is a case company, which was founded in 2007 and develops a unique touch technology targeting a wide range of screens sizes and applications. External capi