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Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. In an effort to stratify EGFRwt tumors, our group discovered in previous

Den 1 juli 2018 trädde den så kallade samtyckeslagstiftningen ikraft, vilket innebar en stor förändring i den svenska regleringen av våldtäktsbrottet. Lagstiftningen blev nu frivillighetsbaserad och samtidigt infördes ett nytt brott, oaktsam våldtäkt. Straffansvar i våldtäktsmål är därmed även aktuellt då den tilltalade agerat grovt oaktsamt. Denna uppsats syftar till att klargöra hur domstolar reIn 2018, Sweden passed a new law regarding rape, which is based on consent. Prior to this, a certain amount of force or threat was required, but the current legislation is based on the lack of voluntary participation. A new offense was passed, negligent rape. Thus, criminal liability for rape does not only come in question in cases of intent, but also in cases of gross negligence. The main purpose

Background: Repolarization prolongation can be the earliest electrophysiological change in ischemia, but its role in arrhythmogenesis is unclear. The aim of the present study was to evaluate the early ischemic action potential duration (APD) prolongation concerning its causes, expression in ECG and association with early ischemic ventricular fibrillation (phase 1A VF). Methods: Coronary occlusion

Core-shell nanoparticles have gathered much attention of the scientific community owing to their potential applications in various fields including biomedical imaging and catalysis. Predicting core-shell preference1-3 is, however, still largely based on a few experimental observations and limited theorical studies, and hence development of new core-shell nanoparticles is normally built on a trial-

Lärares praktiska yrkeskunskaper bjuder motstånd mot förspråkligande. Detta problem föreligger inte minst i lärarutbildningen, där det i verksamhetsförlagda delar kan råda både osäkerhet och skilda uppfattningar om vad studenterna behöver göra eller prestera för att uppnå de mål som (bokstavligen) föreskrivits dem. Syftet med avhandlingen har varit att beskriva och förstå villkor och förutsättningTeachers' practical professional skills offer resistance to advocacy. This problem exists not least in teacher education, where in work-based parts there can be both uncertainty and different perceptions of what the students need to do or perform in order to achieve the goals that are (literally) prescribed for them. The purpose of the dissertation has been to describe and understand conditions an

This paper summarized the efforts performed to understand decay heat estimation from existing spent nuclear fuel (SNF), under the auspices of the Working Party on Nuclear Criticality Safety (WPNCS) of the OECD Nuclear Energy Agency. Needs for precise estimations are related to safety, cost, and optimization of SNF handling, storage, and repository. The physical origins of decay heat (a more correc

Denna uppsats undersöker räckvidden av det straffrättsliga ansvaret för försök till sexualbrott mot barn på nätet när polisen uppträder som barn, samt hur detta ansvar förhåller sig till rätten till en rättvis rättegång enligt artikel 6 i EKMR. Rättsläget har förändrats påtagligt under de senaste åren. Genom NJA 2023 s. 393 ”Vapenattrappen” preciserade Högsta domstolen det straffbara området för This thesis examines the scope of criminal liability for attempted sexual offences against children online when a police officer impersonates a child, and how this liability relates to the right to a fair trial under Article 6 of the ECHR. The legal position has shifted markedly in recent years. In NJA 2023 p. 393 "Vapenattrappen" (The weapon replica), the Supreme Court of Sweden clarif

We find ourselves in the midst of a remarkable technological revolution, with rapid advancements in fields such as artificial intelligence, robotics and information technology. Consequently, there is a pressing need for low-power technologies that are not reliant on continuous power supply. The field of spintronics aims to resolve this by coupling electric and magnetic properties. To pave the way

Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical AD

Här behandlas Sveriges förbindelser med andra politisk-territoriella enheter, frånmedeltidens dynastiska unioner över de tidigmoderna konglomeratstaterna till1800-talets union av två nationalstater. Med hjälp av befintlig forskning fokuserasstatens växlande sammansättning och vikten av att skilja mellan riket och staten.Ett sådant perspektiv visar nya aspekter och ställer frågor som ett traditioneDuring most of the period from 1319 to 1905, the kingdom of Sweden formed part of a larger state, either through union with other states or through the possession of provinces that were not part of the kingdom proper. This is a neglected theme in Swedish historiography, where Sweden is described as a trans-historical entity, sometimes larger and sometimes smaller than the present state but still b

Popular Abstract in Swedish Förbränning förknippas av många som förlegat. Att utvinna energi genom att ”elda” har människan gjort under årtusenden, men trots det bestod Sveriges totala energiproduktion 2004 till 52 % av förbränning. De flesta bilar, båtar, flyg och i vissa fall även tåg utnyttjar den kemiskt lagrade energin i fossila bränslen. Uppvärmningen av bostäder är inte heller att förringa,The thesis work, aimed at the development of laser-spectroscopic detection schemes, consists of three parts, concerned with the development and application of different techniques. The development of UV filtered Rayleigh scattering (FRS) for thermometry and fuel/air ratio measurements, using a frequency tripled, single-longitudinal-mode alexandrite laser at ~254 nm together with an isotopically en

This report is the thesis of the research and development project entitled: Development of a Resource Saving Concept for the Establishment of a Climate Suitable for the Storage of Objects Worthy of Preservation in Storerooms at Museums and in Archives. In short: The ZEPHYR project. This work is the result of a research and development project. The aim is to improve the possibilities of using pass

Both the EU and Member States in treatment of third-country nationals have to follow so-called “international minimum standard of treatment of aliens”, meaning that states are allowed to treat aliens in the same way as their own nationals, but in no case such treatment to be less than fundamental human rights stipulated in contemporary international instruments. Such standard is not stipulated in

Syftet med uppsatsen är att utreda gränsdragningen av ett samtyckes ansvarsbefriande verkan vid misshandelsfall av normalgraden i sexuella sammanhang. Dessa fall rör sig i gränslandet mellan det straffbara och det straffria. Uppsatsen utreder gränslandet genom att se till hur ett ansvarsbefriande samtycke är uppbyggt. Det konstateras att det krävs ett giltigt samtycke och att själva gärningen inteThe purpose of this bachelor thesis is to investigate the boundary of a consent exonerating effect on assaults of the normal degree made in a sexual context. Such cases are located at the boundary between the criminal and impunity. The paper investigates the boundary area by looking at how an exonerating consent is constructed. It is noted that there is a need for a valid consent and that the act

Abstract Authors: Ingrid Leandersson, Malin Jönsson Title: The situation of children at women’s shelters – A qualitative study of the work with children in women’s shelters based on the staff’s perspective Supervisor: Malinda Andersson Assessor: Mikael Sandgren The purpose of our essay was to highlight the situation among children in women's shelters in Sweden in addition to inquire into t

General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investig

The first paper, Pharmaceutical R&D: a real option approach, considers the process of pharmaceutical R&D analyzed with real option theory. This process is analyzed as an opportunity to research and develop a new pharmaceutical. Contrary to other models using real option analysis I use an option that takes time to exercise. Thus, the important aspect of long R&D processes when developin

The aim of this thesis was to study onlay bone grafting in the adult rat to improve graft incorporation and perservation of graft size. In 167 adult isogeneic lewis rats, the size maintenance and bone formation at the graft-host interface of uni- and bicortical onlays positioned in various environments and treatments were investigated. The findings were assessed after four, 12 and 20 weeks with ro

To date, it is widely accepted that several disorders of the male and female urogenital tract, such as erectile dysfunction, bladder overactivity, urinary stone disease and the benign prostatic syndrome, can be therapeutically approached by influencing the function of the smooth musculature of the respective organs. In order to achieve a pronounced drug effect without significant adverse events, e

Whitewater from production of packaging board was treated in a combined anaerobic/aerobic biokidney, both in laboratory scale and pilot plant experiments. Both the laboratory experiments and the pilot plant trial demonstrate that a combined anaerobic/aerobic process is suitable for treating whitewater from a packaging mill. It is also possible to operate the process at the prevailing whitewater te