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MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion

In this paper the PreAmplifier ShAper (PASA) for the Time Projection Chamber (TPC) of the ALICE experiment at LHC is presented. The ALICE TPC PASA is an ASIC that integrates 16 identical channels, each consisting of Charge Sensitive Amplifiers (CSA) followed by a Pole-Zero network, self-adaptive bias network, two second-order bridged-T filters, two non-inverting level shifters and a start-up circu

Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib

Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel

Evaluation, prioritization and selection of candidate requirements are of tremendous importance and impact for subsequent software development. Effort, time as well as quality constraints have to be taken into account. Typically, different stakeholders have conflicting priorities and the requirements of all these stakeholders have to be balanced in an appropriate way to ensure maximum value of the

Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in

The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl

The aim of this thesis is to critically investigate the discourses of Sweden’s Art and Music Schools (SAMS, kulturskolor in Swedish) connected to policy processes for the democratisation of music education for all children and adolescents. A further aim is to contribute to knowledge on the development and enactment of policy processes for the democratisation of music education. The empirical materThe aim of this thesis is to critically investigate the discourses of Sweden’s Art and Music Schools (SAMS, kulturskolor in Swedish) connected to policy processes for the democratisation of music education for all children and adolescents. A further aim is to contribute to knowledge on the development and enactment of policy processes for the democratisation of music education. The empirical mater

The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh

Ash is produced in combustion of biomass. Sonic part of this matter is called fly ash and is carried by the flow and causes not only air pollution and erosion, but also call affect the thermal radiation. The effects of fly ash particles oil the thermal radiation are considered ill this investigation. By analyzing sampled data in all electrostatic filter, a realistic particle size distribution is f

The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit

Applicant Summary for applicants to LUCAS and LUMES PAGE 1 OF 2 I am applying to start LUCAS and/or LUMES in (year): Applicant Summary for applicants to LUCAS* and LUMES** First register at www.universityadmissions.se to get your application number. *Lund University International Master’s programme in Climate Change and Society, **Lund University International Master’s programme in Environmental S

https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-11/A_S_LUCAS-LUMES.pdf - 2026-05-30

Welcome to the Pufendorf Institute Your administrative guide Here you will find vital, practical and interesting information on fire safety, locks and alarms, our work procedures at the institute, how we can help, whom to contact in various situations and who is responsible for what. Staff at the Pufendorf Institute The staff of the institute are director Ann-Katrin Bäcklund , coordinator Eva Pers

https://www.pi.lu.se/sites/pi.lu.se/files/house_guide_2019.docx - 2026-05-30

Putting Circular Ambitions into Action: The Case of Accus, a Small Swedish Sign Company HERVÉ CORVELLEC, DEPARTMENT OF SERVICE STUDIES, LUND UNIVERSITY, SWEDEN MAIRA BABRI, SCHOOL OF BUSINESS, ÖREBRO UNIVERSITY, SWEDEN HERMAN I. STÅL, UMEÅ SCHOOL OF BUSINESS, ECONOMICS AND STATISTICS, UMEÅ UNIVERSITY, SWEDEN 2 Foreword In June 2017, the sign company Accus in Malmö applies for funding from Vinnova

https://www.ses.lu.se/sites/ses.lu.se/files/corvellec_babri_stal_2019_accus_rapport.pdf - 2026-05-30

Background and aimHypoxic-ischaemic encephalopathy (HIE) is a leading cause of morbidity and mortality in unconscious patients resuscitated after out-of-hospital cardiac arrest. Many patients die after withdrawal of life-sustaining treatments (WLST), often due to a presumed poor prognosis. To minimise the risk of premature WLST, guidelines recommend using a multimodal prognostication. Head compute