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Antibiotic resistance is currently an extensive medical challenge worldwide, with global numbers increasing steadily. Recent data have highlighted wastewater treatment plants as a reservoir of resistance genes. The impact of these findings for human health can best be summarized using a One Health concept. However, the molecular mechanisms impacting resistance spread have not been carefully evalua

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Feedbacks mechanisms are essential components of our climate system, as they either increase or decrease changes in climate-related quantities in the presence of external forcings. In this work, we provide the first quantitative estimate regarding the terrestrial climate feedback loop connecting the increasing atmospheric carbon dioxide concentration, changes in gross primary production (GPP) asso

The interaction of blood coagulation factor X and its Gla-containing fragments with negatively charged phospholipid membranes composed of 25 mol% phosphatidylserine (PtdSer) and 75 mol% phosphatidylcholine (PtdCho) was studied by surface plasmon resonance. The binding to 100 mol% PtdCho membranes was negligible. The calcium dependence in the membrane binding was evaluated for intact bovine factor

This thesis demonstrates the usefulness of sedimentary pigments as biomarkers of environmental change in estuarine systems and as biomarkers in lakes in relation to climate change. These are two fields where sediment pigment records as measured by high-performance liquid chromatography (HPLC) are emerging areas of study. A detailed study was undertaken to examine the effects of different storage o

Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b

The rise of Social Network Sites (SNS) has had a huge impact on the field of public relations in that brands must now consider online branding as part of their strategy. This is a growing area of interest in both academia and practice as we strive to learn more about how to use the new platforms most effectively. In particular, SNS have encouraged the social role of brands and allow consumers enga

Stability is a fundamental property affecting function, activity, and regulation of biomolecules. Stability changes are often found for mutated proteins involved in diseases. Stability predictors computationally predict protein-stability changes caused by mutations. We performed a systematic analysis of 11 online stability predictors' performances. These predictors are CUPSAT, Dmutant, FoldX, I-Mu

Background: Health professions education programs are tasked with designing curricula to effectively andefficiently equip their graduates with the required competences and life-long learning skills needed fortoday’s fast-paced, knowledge intensive society. Continuous monitoring and improving of educationalquality is essential to attain these goals. Quality assurance is multi-faceted and requires t

Groundwater is a major source of drinking and agricultural water supply in arid and semiarid regions. Poor groundwater quality can be a threat to human health especially when it is combined with hazardous pollutants like heavy metals. In this study, an innovative method involving entropy weighted groundwater quality index for both physicochemical and heavy metal content was used for a semiarid reg

During the 1990s several kinds of reorganization has taken place in public services in Sweden. Reorganizations according to the idea of market economy have been most salient and debated. In many municipalities private companies have started to organize home care service for elderly, financed by tax. Public home care organizations have reorganized the working organization and managing structure, pa

Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b

Purpose: Recent studies have highlighted the importance of adopting a contingency approach to configuring omnichannel warehouses. Nonetheless, research on how various contextual factors influence the selection of warehouse configuration is scarce. This study fills this knowledge gap by exploring how and why certain configurations fit in different omnichannel contexts. Design/methodology/approach:

Matching habitat choice is a habitat preference mechanism based on self-assessment of local performance, such that individuals settle in the habitats that are best suited to their phenotypes, promoting local adaptation. Despite the important evolutionary implications of matching habitat choice, examples from natural populations are rare. One possible reason for this apparent rarity is that phenoty

Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host–pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick-transmitted bacterium Borrelia afzelii. We determined prevalence an

Brevmall Postal address Sölvegatan 37, 223 62 Lund Internal mailing code 50 Visiting address Ekologihuset, Sölvegatan 37 Telephone +46 46 222 00 00 E-mail Eivor.Terne@cec.lu.se Centre for Envi ronmenta l and Cl imate Research Work environment policy for Norunda research station Approved by the CEC board 12 May 2014. Revised 25 November 2016. Norunda is a unit within Lund University’s Centre for En

https://www.cec.lu.se/sites/cec.lu.se/files/work_environment_policy_norunda_2016.pdf - 2026-05-27

Creating an individual study planThe Higher Education Ordinance states that an individual study plan must be drawn up and established for each PhD student. The individual study plan must:define the content and implementation of the programme in terms of the scientific project, courses and seminars, etc.include a timetable for the student's PhD education and specify how the student's supervision is

https://www.intramed.lu.se/en/phd-studies/admission-examination/planning-your-phd-studies/individual-study-plans - 2026-05-25

Reliable information on solar activity over the Holocene period is important to predict the Sun in the future and to understand the mechanism behind the Sun-climate linkage. Presently, there are discrepancies in the proxy data of solar activity due to reasons that are not yet understood. This leads to major uncertainties in Holocene solar reconstructions. This PhD project aims to improve the Holoc

The effects of data uncertainty in applications of the critical loads concept were investigated on different spatial resolutions in Sweden and northern Czech Republic. Critical loads of acidity (CL) were calculated for Sweden using the biogeochemical model PROFILE. Three methods with different structural complexity were used to estimate the adverse effects of SO2 concentrations in northern Czech R

Popular Abstract in Swedish Vad är det för något i human mjölk som dödar cancer celler? Kan “fel” veckade proteiner vara nyttiga? Kan fett vara inblandat i protein veckning? Det är några av frågorna som tas upp i denna avhandling. Allt levande består av proteiner som i sin tur är uppbyggda av amino syror. Det finns 20 st. olika amino syror som på olika sätt kan länkas samman till proteinkedjor. DBy varying its secondary or tertiary structure a single protein can attain new biological functions. The amyloid forming proteins are the best known examples where a change in conformation leads to the formation of amyloid fibrils that accumulate in tissues and cause disease. a-lactalbumin in contrast, is an example of a protein that acquires a beneficial function when the conformation is altered