Generation and optimization of cellular models for investigation of mechanisms underlying Parkinson´s disease
Parkinson’s disease (PD) is considered one of the most frequent neurodegenerative disorders amongst elderly people. PD leads to loss of dopaminergic neurons in substantia nigra of the brain giving symptoms such as slowness of movement and dementia. PD brains have been found to contain accumulations of a protein named alpha‐synuclein (α‐syn). Additional to its aggregation propensity in PD it is als
