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Breast cancer is one of the most common cancers in women. It is most commonly treated by the surgical removal of the tumour in combination with (neo)-adjuvant therapy (hormone, chemo- or radio- therapy before or after surgery). However, a large number of patients are over treated, with approximately 60% being given adjuvant therapy when already cured by surgery alone. This causes many undesirable

That Florida is in the midst of an ecological crisis is a perspective increasingly shared by academy, government, private industry and civil society. Ideas about the causes of the state’s environmental problems and how best to address them, however, are not so well aligned. While some are prone to emphasize the primacy of economic growth over environmental conservation, others argue that, like lov

Background: Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. The sensitivity of mammography is lower in dense breasts, and additional imaging techniques are sometimes warranted. Contrast-enhanced mammography (CEM) has shown similar sensitivity and in some cases better specificity, than magnetic resonance imaging (MRI) in small, obser

Even though the validity of x-ray computed tomography in the analysis of biomedical samples is nowadays undisputed, the more recent imaging techniques and more advanced instruments (such as synchrotrons) are still relatively unknown to many medical doctors that could benefit from them.The doctoral work presented in this thesis joins a collective effort from the imaging community to demonstrate pot

Benthic fluxes of dissolved silicon (Si) from sediments into the water column are driven by the dissolution of biogenic silica (bSiO2) and terrigenous Si minerals and modulated by the precipitation of authigenic Si phases. Each of these processes has a specific effect on the isotopic composition of silicon dissolved in sediment pore fluids, such that the determination of pore fluid 30Si values can

Det övergripande syftet med denna licentiatavhandling är att öka kunskapen kring vad som påverkar att jobba som en brandman vars huvudsakliga sysselsättning är utanför räddningstjänsten (exempelvis frivilliga brandmän eller deltidsbrandmän) för att förstå hur utmaningar och engagemang påverkar beslutet att fortsätta vara verksam. Bibehållandet av dessa brandmän är en välkänd utmaning i många ländeThe overarching aim of this licentiate thesis is to increase knowledge about the implications of working as a non-career firefighter in order to understand how challenges and commitment affect retention. Retention of non-career firefighters (for example volunteer or part-time firefighters) is a well-known, multifaceted challenge in several countries. These non-career firefighters account for the m

The molecular sensitivity provided by optical photons has potential advantages in medical diagnostics, for example, in distinguishing healthy from cancerous tissue. However, scattering resulting from inhomogeneities in the refractive index of tissues prevents spatially resolved optical measurements in biological material, except at very shallow depths. This thesis presents research on a medical im

The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LL-37 displays direct antimicrobial activity against a variety of pathogens, but also modulates the immune responses by ac

With an ageing population and a discourse of active ageing guiding welfare policies, initiatives to engage older people in health promoting activities have been established. One growing phenomenon is Senior Summer Camps, arranged all over Sweden in beautiful natural environments close to water. Their main purpose is to enable older people to participate in outdoor activities in an institutionalize

IntroductionAn overview of the different hybrid-processes combining pervaporation with a conventional separation as a tool to recover organic compounds from waste water will be given. Analysing potential applications shows that pervaporation alone will rarely be economical due to the purity required nowadays in waste water treatment. The limitation on flux owing to the activity being the driving f

Popular Abstract in Swedish Antikroppar är proteiner som ingår i kroppens immunförsvar, där de fungerar som bindare för att neutralisera patogena mikroorganismer eller ämnen som infekterat kroppen. Vid en infektion börjar immunceller producera antikroppar genom att på ett smart sätt sätta ihop olika gener. Varje enskild immuncell använder en viss kombination av gener och producerar därmed antikropRecombinant antibody microarrays have advanced into indispensable tools for large-scale, high-throughput multiplexed serum proteomics. This thesis, based upon five original papers, deals with the development of an in-house designed antibody microarray platform, and its applications for serum profiling of pancreatic disease. Pancreatic cancer is the 4th deadliest cancer, with a 5-year survival rat

Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. Classical reaction engineering was combined with genetic engineering to improve the production of chiral alcohols and kinetic resolution of racemic ketones with high enantiomer

Background: Sexual dimorphism occurs widely across the animal kingdom and has profound effects on evolutionary trajectories. Here, we investigate sex-specific gene expression in Ischnura elegans (Odonata: dragonflies and damselflies), a species with pronounced sexual differences including a female-limited colour polymorphism with two female-like gynochrome morphs and one male-mimicking, androchrom

Human CaCo-2 cells were incubated with [14C]linoleic (18:2(n - 6)), [14C]linolenic (18:3(n - 3)) and [3H]eicosapentaenoic acid (20:5(n - 3)), and the interconversion of the radioactive fatty acids to higher homologues and their acylation into triacylglycerols (TG) and phospholipids were examined. An active conversion of [14C]18:3 to [14C]20:5 and [14C]docosapentaenoic acid (22:5(n - 3)) and of [3H

The need for energy in water provision and use is obvious, however the drivers are often complex, difficult to assess, and often inconsistently presented. Here we build a clearer definition and conceptual framework of “water-related energy”. We apply this framework to harmonise data and results across disparate studies so that regional estimates of water-related energy can be compared in a consist

Avhandlingen behandlar den socialistiska respektive den liberala internationella fredsrörelse som agerade under kvartsseklet före första världskrigets utbrott 1914.During the 25 years before the First World War in 1914 two different kinds of peace movements, one bourgeois-liberal and one socialist, were organised to fight militarism and war. The two movements – represented by the International Peace Bureau and the Second International, respectively – grew in size between 1889 and 1914. At the beginning of 1914, IPB organized over 200 peace associations, repr

När vi människor försöker röra på oss skickas elektriska impulser genom nervsystemet från hjärnan ner till de muskler som är inblandade i den tilltänkta rörelsen. Att kunna mäta sådana nervimpulser hade varit av värde för en rad tillämpningar—information hade då kunnat överföras direkt från nervsystemet utan att gå via långsamma, mekaniska gränssnitt så som tangentbord och pekskärmar. OlyckligtvisElectrical activity produced by muscles during voluntary movement is a reflection of the firing patterns of relevant motor neurons and, by extension, the latent motor intent driving the movement. Once transduced via electromyography (EMG) and converted into digital form, this activity can be processed to provide an estimate of the original motor intent and is as such a feasible basis for non-invas