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Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif

Human blood group A and B antigens are produced by two closely related glycosyltransferase enzymes. An N-acetylgalactosaminyltransferase (GTA) utilizes UDP-GalNAc to extend H antigen acceptors (Fuc alpha(1-2)Gal beta-OR) producing A antigens, whereas a galactosyltransferase (GTB) utilizes UDP-Gal as a donor to extend H structures producing B antigens. GTA and GTB have a characteristic (DVD213)-D-2

Preterm birth and psychiatric medication prescription in young adulthood: a Swedish national cohort study.

BACKGROUND: Recent studies suggest an increased risk of adverse mental health outcomes among young adults who were born preterm. These studies have been based mainly on hospital data, thus missing large numbers of mental health problems that do not require inpatient treatment. We used national outpatient and inpatient pharmacy data to evaluate whether individuals who were born preterm were more li

Voice Imitation : A Phonetic Study of Perceptual Illusions and Acoustic Success

Popular Abstract in Swedish I denna avhandling presenteras olika studier om röstimitation. Det unika i den individuella rösten och om det är möjligt att förändra sin röst så att man blir till förväxling lik någon annan vad gäller rösten och talet diskuteras. Syftet med studierna var i första hand att ta reda på hur och i vilken omfattning en imitatör förändrar sin egen röst och sitt tal för att blThis thesis is about voice imitations, more specifically impersonation. Questions are raised about the uniqueness of a person’s voice and speech behaviour and if it is possible to get close to another speaker’s voice and speech. Four main research questions are investigated in different studies. The studies focus mainly on how close the imitation is to the target speaker, and addresses to a lesser

Att förhandla litterärt värde – Sami Said och Väldigt sällan fin

This article aims to highlight how literary value is constructed today: how it is created and negotiated. It seeks to develop a perspective that considers the manifold and complex value­negotiation process. In accordance with Barbara Herrnstein Smith, the article argues that literary value is generated by a constant and continuous series of negotiations between production and sale: the institution

Concentration variability of potent allergens of p-tert-Butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR.

Background: p-tert-Butylphenol-formaldehyde resin (PTBP-FR) is a common component of glues used in the manufacturing of many plastic, electronic, rubber, wood, and leather products. Two main allergens of PTBP-FR have been described. Objectives: The objective of this study is to determine the concentrations of the two main allergens of PTBP-FR in diagnostic patch testing preparations and PTBP-FR av

The foot in perspective.

The diabetic foot constitutes a tremendous challenge for patients, caregivers and the health care system. The International Consensus Document of 1999 was a milestone in the recognition of the importance and consequences of the diabetic foot. Since then, many original papers have been published in this area.Large cohort studies have given us a deeper understanding regarding factors related to the

Gene-Viral Cancer Therapy Using Dual-Regulated Oncolytic Adenovirus with Antiangiogenesis Gene for Increased Efficacy.

Conditionally replicative adenovirus (CRAD) represents a promising approach for cancer therapy. Several CRADs controlled by the human telomerase reverse transcriptase promoter have been developed. However, because of their replicative capacity, the importance of cancer specificity for CRADs needs to be further emphasized. In this study, we have developed a novel dual-regulated CRAD, CNHK500-mE, wh

Meeting Diversities in Maritime Education, a blend from World Maritime University

To address a diversified student complement in academic studies is becoming more and more frequent in maritime education and training. Diversity challenges are also the reality onboard ships that muster a multicultural crew complement. This thesis aims at creating awareness on dilemmas and challenges that students and faculty meet when working in a multicultural environment. In order not to have

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease.

Huntington's disease (HD) is the most prevalent polyglutamine expansion disorder. HD is caused by an expansion of CAG triplet in the huntingtin (HTT) gene, associated with striatal and cortical neuronal loss. Central and peripheral metabolic abnormalities and altered insulin-like growth factor-1 (IGF-1) levels have been described in HD. Thus, we hypothesized that restoration of IGF-1-mediated sign

A post-patent-torpedo EU? - An analysis of the Unitary Patent Package’s impact on torpedo actions within the EU

Patent suits are among the more expensive legal endeavours a party can partake in. The best-case scenario for patentees is a cease-and-desist letter, where the threat of an impending suit convinces the alleged infringer stop altogether. If the alleged infringer insists, a court solves the matter and business may continue as usual. In the EU however, this chain of events is complicated by the possi

Staten hör dig: En utredning av hemlig telefonavlyssning i förhållande till rättssäkerhet och integritetsskyddet

De brottsbekämpande myndigheterna har i flera år mottagit hård kritik för brister i deras hantering av hemlig telefonavlyssning. Dessa brister har utgjorts av systematiska fel i myndigheternas rutiner avseende förstöring av material och underrättelse till enskild om användningen av hemlig telefonavlyssning. Myndigheterna har även använt hemlig telefonavlyssning utan erforderligt tillstånd. I ett fFor several years, the law enforcement authorities have received severe criticism for their handling of secret telephone tapping. The criticism concerned systematic errors in their routines regarding both the destroying of materials obtained through secret telephone tapping and in notifying individuals about its use. The authorities have also used secret telephone tapping without the required perm

Maintaining the Court of Justice of the European Union's Legitimacy and Upholding the Rule of Law – an Uneven Equation?

The dismantling of the rule of law in a number of Member States of the EU continues. Recently, the Court of Justice has become the centre of attention of the rule of law crisis, due to the pending case C-619/18 Commission v Poland, concerning the independence of the judiciary in Poland. The Advocate General found in his Opinion to the case that the Polish law that lowered the retirement age of the

Sweden’s implementation of DAC 6 – A proportionate measure to prevent tax avoidance and evasion in the form of aggressive tax planning

After the financial crisis in 2008, governments became more aware about how multinational enterprises exploited gaps in the architecture of the international tax system in the globalized world to artificially shift profits to places where there was little or no taxation. It is estimated that base erosion and profit shifting cost countries 100-240 billion USD in lost revenue annually which is equal

Biblioteket som låntagare : förlorad kontroll eller ny möjlighet? En studie av tre forskningsbiblioteks handhavande och handel med licensierat material

The focus of this thesis is the issues regarding the administration of licensed academic resources in resarch libraries and the role of the research library when trading with these resources. It is explored what possibilities and dangers that comes with the ways that libraries handle academic resources, ways that are closely linked to the market criteria in which external commercial actors in diff

Erkännandets betydelse. Romska kvinnors syn på utbildning som en väg mot inkludering.

Author: Karin Andréasson and Elin Björk Title: The meaning of recognition. –Romani women’s experiences of education as a way to inclusion. Supervisor: Hanna Wittrock Assessor: Elizabeth Martinell Barfoed The aim of this study was to examine the situation of Romani women in Sweden. More specifically, to investigate Romani women’s experiences of and view on education as a way to increase the inclu

Protective Earplug Designed for Water Activities

This report is a result of a Master Thesis in Mechanical Engineering with Product Development at the Faculty of Engineering, Lund University. The Master Thesis was performed during the spring of 2012 at Frankly Development in Malmö. Frankly is Product Creation Company with great knowledge in developing consumer electronics, sports equipment and other type of products. The thesis was initiated by C

Biofilm formation in a large sized experimental set up of a drinking water distribution system consisting on various pipe materials

Populärvetenskaplig sammanfattning: Drick ett glas goda bakterier Man har länge vetat att det i distributionsnät av dricksvatten växer bakterier i form av biofilm. Denna biofilm kan stabilisera vattenkvaliteten men kan också vara orsaken till vissa hälsoproblem eftersom den kan innehålla patogener, virus och protozoer. Djupare förståelse om hur biofilmer är uppbyggda och fungerar är också av int

Problemet med marin påväxt och dess lösningar

With a fuel consumption of up to 150 tons a day for a containership, fuel cost is the main expense for shippers. To decrease expenses, drag reduction is the most important topic to address. The biggest factor that influence the hydrodynamics of a vessel is marine fouling. A heavily fouled ship can consume an additional 40 % of fuel or more. The process of marine fouling is an extremely diverse and