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BACKGROUND: Recent reports have shown that, although rare, findings of mucosal ulcers and perforations of the nasal septum in some cases may be associated with the use of topical nasal glucocorticosteroids (GCS). It can been speculated that, a reduction in septal mucosal blood flow causing ischemia may eventually induce septal perforations. AIM: To evaluate whether a single dose of a potent nasal

Understanding the molecular mechanisms behind beta cell dysfunction is essential for the development of effective and specific approaches for diabetes care and prevention. Physiological human beta cell models are needed for this work. We review the possibilities and limitations of currently available human beta cell models and how they can be dramatically enhanced using genome-editing technologies

This work focuses on the optimization of the Nuclear Reaction Analysis (NRA) technique to determine the content of lithium and fluorine in geological materials. Measuring low concentration of these isotopes is of great relevance in many fields such as geological, astrophysical, biological and material sciences. Light elements as lithium and fluorine are considered as geochemical tracers in various

Kidney transplant candidates may be incompatible with their intended living donors because of the presence of antibodies against HLA and/or ABO. To increase the possibility of finding an acceptable kidney donor for these patients, the Scandiatransplant Exchange Program (STEP) program within Scandiatransplant was launched in 2019. Methods. This is a retrospective review of our experiences from the

Recent progress in chemical vapour deposition (CVD) technology has enabled synthesis of metastable cubic Ti1−xAlxN coatings with x as high as 0.8–0.9. These coatings have unique micro- and nano-structures consisting of grains with epitaxially grown nanolamellae with different Al/Ti ratios, and exhibit exceptional hardness and resistance to wear and oxidation. Here, the thermal stability and decomp

Gas-liquid mass transfer in wastewater treatment processes has received considerable attention over the last decades from both academia and industry. Indeed, improvements in modelling gas-liquid mass transfer can bring huge benefits in terms of reaction rates, plant energy expenditure, acid-base equilibria and greenhouse gas emissions. Despite these efforts, there is still no universally valid cor

In both the Geo and BIM domains, it is widely acknowledged that the integration of geo-data and BIM-data is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - broadly termed as GeoBIM - has a range of potential uses from district study to road safety. However, from the data perspective, this integration raises the qu

The implications of professionalization of civil society organizations have seldom been explored in relation to the governance structure of organizations’ and leaders’ different terms of engagement. This study draws on a survey targeting leaders of Swedish welfare-oriented civil society organizations (N. 140) and compares the motives for engagement and leadership ideals of two groups of leaders: b

Background: Adults with congenital heart disease (ACHD) are a group with an increased risk of thromboembolic complications and arrhythmias. Vitamin K antagonists are the most commonly used thromboprophylaxis therapy in this population. Studies on the efficacy and safety of novel oral anticoagulants (NOAC) are scare in ACHD. A retrospective study on ACHD patients on NOAC treatment registered in the

The death of a parent during childhood is a major traumatic event. While there is a good understanding of the early-life effects of parental loss, the evidence regarding its impact on adult mortality is still scarce. Accordingly, the aim of this article is to study the long-term consequences of parental loss on mortality with a particular focus on differences by socioeconomic status (SES) of the f

As a promising carbon-free fuel, iron powder can directly combust with air and has great potential to provide clean and high-grad heat for various applications. The combustion characteristics of iron particles are of great significance for developing iron combustion model, designing efficient combustor, and optimizing combustion technologies. In this work, the micro-explosion behavior of burning i

The semiconductor technology has enabled the fabrication of integrated circuits (ICs), which may include billions of transistors and can contain all necessary electronic circuitry for a complete system, so-called System-on-Chip (SOC). In order to handle design complexity and to meet short time-to-market requirements, it is increasingly common to make use of a modular design approach where an SOC i

The PHENIX experiment has performed a systematic study of identified charged-hadron (π±, K±, p, p¯) production at midrapidity in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and U+U collisions at sNN=193GeV. Identified charged-hadron invariant transverse-momentum (pT) and transverse-mass (mT) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle