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The most common indication for treatment with warfarin is the prevention of ischemic stroke in patients with atrial fibrillation. Time in therapeutic range (TTR) is an important tool to evaluate the quality of anticoagulation treatment. The aim of this study was to investigate the quality of treatment and the incidence of bleeding complications in patients on warfarin treatment treated by the anti

Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant strains. Antimicrobial peptides (AMPs) form an ancient type of innate immunity found universally in all living organisms, providing a principal first-line of defense against the invading pathogens. The unique

Aim: To establish the current level of knowledge of the effect of drinking cessation on the risk of developing oesophageal cancer. Method: A meta-analysis was conducted based on relevant studies identified through a systematic literature review. A Generalised Least Squares model for trend estimation of summarised dose-response data were utilised in order to estimate the effect of years since drink

Background and Methods: Inhaled insulin has recently emerged as an alternative to subcutaneous insulin administration. One inhaled insulin device, AERx (R) (a registered trademark of Aradigm Corp., Hayward, CA, or its affiliates in the United States and other countries) insulin diabetes management system (iDMS) (Novo Nordisk A/S, Bagsvoerd, Denmark), uses a unique liquid human insulin strip to del

Experimental and epidemiological studies suggest that calcium-regulating hormones-parathyroid hormone (PTH) and vitamin D-may be associated with breast cancer risk. No prospective cohort study has investigated the association between pre-diagnostic calcium levels and subsequent risk of breast cancer. We have examined this in a cohort of 7,847 women where serum calcium levels and established risk f

In recent years, considerable advancements have been made in developing in vitro models to better understand the complex dynamics of the blood-brain barrier (BBB) and its critical role in neurological health and disease. Incorporating astrocytes into these models introduces an essential layer of complexity, allowing for a more comprehensive investigation of the cellular interactions and regulatory

Background and objective: The European Association of Urology (EAU) renal cell carcinoma (RCC) guideline panel has updated their evidence-based guidelines and recommendations for the management of RCC. Here we present a summary of the 2025 RCC guidelines updated with standardised methodology to provide reproducible evidence for the management of RCC. Methods: For the 2025 update, a literature sear

The aim of this study was to describe and to analyze needs and social efforts concerning unaccompanied/separated asylum-seeking children. The responsibility for the reception of this target group was transferred on July 1, 2006 from the Swedish Migration Board to the municipalities that sign an agreement with the Swedish Migration Board. Eight qualitative interviews were carried out with represent

Our state of emergency is good - is the public library prepared for the future? Our state of emergency is good! These are the words spoken by Prime Minister Per Albin Hansson in 1939. He claimed that Sweden had nothing to fear from a future war, we were safe. Today we know it was not so. Is this the situation for Swedish public library of today? Is the public library ready to face the future, or

Fountain of Knowledge? The Changing Role of the Library at the Upper Secondary School Level. There have been many changes in the Swedish society in general, and in the school system and hence the school library in particular during the last decade. The aim of this master thesis is then to study what students at the upper secondary school level consider to be the optimal school library to meet thei

This essay is about children who have psychological and social problems. An increase part of children and young people in Sweden describe this kind of difficulties. These problems are at the same time a concern for the school as well as the social welfare. The purpose in this essay is to explore if children with psychological and social problems have the same legal rights to education as other chi

This master thesis? purpose is to examine the role of Swedish universities in the prevention of extremism and terrorism. Depending on how the universities look upon their role in preventing extremism and promoting democracy among their students, extremism can either flourish or be restrained in the higher learning environment. An unclear standpoint against extremism from the universities side coul

The yeast Saccharomyces cerevisiae is characterized by its ability to: (a) degrade glucose or fructose to ethanol, even in the presence of oxygen (Crabtree effect); (b) grow in the absence of oxygen; and (c) generate respiratory-deficient mitochondrial mutants, so-called petites. How unique are these properties among yeasts in the Saccharomyces clade, and what is their origin? Recent progress in g

Respiratory chain Complex I or NADH:quinone oxidoreductase catalyzes oxidation of NADH in the mitochondrial matrix or bacterial cytoplasm and reduction of quinone in the membrane, coupled to pumping of 4H+/2e- across the membrane. The same enzyme complex is also capable of the reverse reaction, i.e. @D@mH+-supported NAD+ reduction. The molecular mechanism that couples electron transfer to proton p

Peroxidases, oxygenases and catalases have similar high-valent metal-ion intermediates in their respective reaction cycles. In this review, haem-based examples will be discussed. The intermediates of the haem-containing enzymes have been extensively studied for many years by different spectroscopic methods like UV-Vis, EPR (electron paramagnetic resonance), resonance Raman, Mossbauer and MCD (magn