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Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel from cell to cell and spread the pathology through the brain. Throughout the last decade, physiological and pathological tau have become attractive targets for AD therapies. Several therapeut
US-based philanthropies have long contributed to environmental conservation through non-repayable donations, but some are now beginning to embrace novel investment strategies that are profit-orientated. From the vantage points of political economy and geopolitics, this article investigates the potential ramifications of this shift in funding for large-scale marine protected areas (LMPAs), which ha
OBJECTIVE: Familial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified, anxiety in family members; thus the degree of familial clustering of these diseases remains to be established.METHODS: The Multigeneration Register, in which all men (sons) and women (daughters) born in Sweden from 1932 onward are registered together with th
Transfer integrals for oligos with different bases have been calculated using INDO/Koopman's approximation to unveil the charge transport mechanism in DNA. The sequences, G(A)nG, n = 1, 2, …, 10; G(A)xG(A)yG, x + y = 9; and G(A)xG(A)yG(A)zG, x + y + z = 8, were employed to interpret the Guanine (G) and Adenine(A) hopping. Adenine hopping is found to be faster in G(A)nG sequences with longer Adenin
Despite large industrial relevance, the relation between rotor-stator geometry, hydrodynamics and drop breakup is poorly understood, partly since no methods for measuring the fragmenting stresses acting on drops have been established. This study attempts to bridge this gap by developing, applying and evaluating two approaches for estimating local turbulent stresses based on particle image velocime
Monitoring is science keeping our thumb on the pulse of the environment to detect any changes of concern for societies. Basic science is the question-driven search for fundamental processes and mechanisms. Given the firm root of monitoring in human interests and needs, basic sciences have often been regarded as scientifically "purer"-particularly within university-based research communities. We ar
Dopamine replacement therapy effectively relieves the typical motor features of Parkinson disease (PD), but it can cause complications that limit its utility. Dyskinesia (abnormal involuntary movements) and motor fluctuations (abrupt changes in the patients' motor status) occur in most PD patients after a few years of 3,4-dihydroxyphenyl-. l-alanine (l-DOPA) pharmacotherapy. Animal models reproduc
Boreal trees rely on their ectomycorrhizal fungal symbionts to acquire growth-limiting nutrients, such as nitrogen (N), which mainly occurs as proteins complexed in soil organic matter (SOM). The mechanisms for liberating this N are unclear as ectomycorrhizal fungi have lost many genes encoding lignocellulose-degrading enzymes present in their saprotrophic ancestors. We hypothesized that hydroxyl
Evidence that bird odour can encode social information that can be used in chemical communication is growing, but is restricted to a few taxonomic groups. Among birds, diurnal raptors (i.e. birds from the Accipitriformes and Falconiformes order) have always been considered as mainly relying on their visual abilities. Although they seem to have a functional sense of smell, whether their odour can c
Background: Diastasis of the rectus abdominis muscle is a common condition. There are no generally accepted criteria for diagnosis or treatment of diastasis of the rectus abdominis muscle, which causes uncertainty for the patient and healthcare providers alike. Methods: The consensus document was created by a group of Swedish surgeons and based on a structured literature review and practical exper
Ground improvement with lime-cement pillars is becoming increasingly common in the Nordic countries for exploitation of areas with poor stability. However, there is a need for non-destructive methods for volumetric quality control of the ground improvement. The quality control can be divided into two steps where the first include quality control at the installation process with monitoring of produ
The private garden is one of the most important sites for people’s everyday interactions with nature. Although sometimes just consisting of a lawn, a few shrubs and maybe a flower bed, it provides a number of situations where the owner has to reflect on and handle biodiversity and sustainability issues in relation to modern lifestyle. This paper will discuss different aspects of sustainability in
Recent research using repeat photography, long-term ecological monitoring and dendrochronology has documented shrub expansion in arctic, high-latitude and alpine tundra ecosystems. Here, we (1) synthesize these findings, (2) present a conceptual framework that identifies mechanisms and constraints on shrub increase, (3) explore causes, feedbacks and implications of the increased shrub cover in tun
Humans have dramatic, diverse and far-reaching influences on the evolution of other organisms. Numerous examples of this human-induced contemporary evolution have been reported in a number of ‘contexts’, including hunting, harvesting, fishing, agriculture, medicine, climate change, pollution, eutrophication, urbanization, habitat fragmentation, biological invasions and emerging/disappearing diseas
Comprehensive approaches to predict performance of wood products are requested by international standards, and the first attempts have been made in the frame of European research projects. However, there is still an imminent need for a methodology to implement the durability and moisture performance of wood in an engineering design method and performance classification system. The aim of this stud
