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What Became of the New Public Diplomacy? : Recent Developments in British, U.S. & Swedish Public Diplomacy Policy and Evaluation Methods

This article examines the relationship between theories of the ‘new’ public diplomacy and recent attemptsby foreign ministries in the United Kingdom, United States and Sweden to develop public diplomacystrategies for the early twenty-first century. It provides a summary of policy debates in each nation alongsideanalysis of the evaluation methods that have been designed to support them. The article

Can we identify a 'high risk' patient profile to determine who will experience rapid progression of osteoarthritis?

Disease modifying drugs for osteoarthritis (OA) that may halt or retard joint destruction and at the same time possibly improve symptoms are being developed and tested at various stages in clinical trials. This has, for at least two reasons, focused attention on the need for identification of patient groups at high risk for incident or progressive OA. First, well characterized such groups may be u

Induction of the nuclear proto-oncogene c-fos by the phorbol ester TPA and v-H-Ras.

TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interac

Usage-Based Reading - An Experiment to Guide Reviewers with Use Cases

Reading methods for software inspections are used for aiding reviewers to focus on special aspects in a software artefact. Many experiments have been conducted for checklist-based reading and scenario-based reading concluding that the focus is important for software reviewers. This paper describes and evaluates a reading technique called usage-based reading (UBR). UBR utilises prioritised use case

Organizational factors affecting product innovation capability: Findings from the Med-Tech industry

Research in innovation has resulted in much applicable knowledge in terms of tools, methods and processes. However, the challenge of allowing “space”, time and competence for innovation capability development is sparsely reported. The purpose of this research is to identify how organizational and behavioral factors affect product innovation capability and its development in organizations. The rese

Stability of HAMLET--A kinetically trapped {alpha}-lactalbumin oleic acid complex.

The stability toward thermal and urea denaturation was measured for HAMLET (human -lactalbumin made lethal to tumor cells) and -lactalbumin, using circular dichroism and fluorescence spectroscopy as well as differential scanning calorimetry. Under all conditions examined, HAMLET appears to have the same or lower stability than -lactalbumin. The largest difference is seen for thermal denaturation o

Interactions between n-octyl and n-nonyl beta-D-glucosides and alpha- and beta-cyclodextrins as seen by self-diffusion NMR

In this work H-1 NMR self-diffusion experiments have been performed to determine the self-diffusion coefficients of n-octyl beta-D-glucoside and n-nonyl beta-D-glucoside in alpha-cyclodextrin and beta-cyclodextrin solutions at 25 degreesC. Two questions are addressed. The first concerns the general influence on nonionic surfactant transport properties when cyclodextrins are present in solution. Th

Structure of SP-B/DPPC Mixed Films Studied by Neutron Reflectometry.

The structures of films of SP-B and mixtures of SP-B and DPPC at the air/water interface have been studied by neutron reflectometry (NR) and Langmuir film balance methods. From the film balance studies we observe that at very high pressures the isotherms of pure DPPC and SP-B/DPPC mixtures very nearly overlay one another, suggesting that the SP-B is being excluded from the film. The use of multipl

The modular organisation and stability of a thermostable family 10 xylanase

The thermophilic marine bacterium Rhodothermus marinus produces a modular family 10 xylanase (Xyn10A). It consists of two N-terminal family 4 carbohydrate binding modules (CBMs) followed by a domain of unknown function (D3), and a catalytic module (CM) flanked by a small fifth domain (D5) at its C-terminus. Several truncated mutants of the enzyme have been produced and characterised with respect t

Simultaneous inference of a binary composite endpoint and its components

Binary composite endpoints offer some advantages as a way to succinctly combine evidence from a number of related binary endpoints recorded in the same clinical trial into a single outcome. However, as some concerns about the clinical relevance as well as the interpretation of such composite endpoints have been raised, it is recommended to evaluate the composite endpoint jointly with the involved

Experimental Confirmation of Transformation Pathways between Inverse Double Diamond and Gyroid Cubic Phases

A macroscopically oriented double diamond inverse bicontinuous cubic phase (Q(II)(D)) of the lipid glycerol monooleate is reversibly converted into a gyroid phase (Q(II)(G)). The initial Q(II)(D) phase is prepared in the form of a film coating the inside of a capillary, deposited under flow, which produces a sample uniaxially oriented with a < 110 > axis parallel to the symmetry axis of the sample

Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.

Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) pop

Formation of extended covalently bonded Ni porphyrin networks on the Au(111) surface

The growth and ordering of {5,10,15,20-tetrakis(4-bromophenyl)porphyrinato}nickel(II) (NiTBrPP) molecules on the Au(111) surface have been investigated using scanning tunnelling microscopy, X-ray absorption, core-level photoemission, and microbeam low-energy electron diffraction. When deposited onto the substrate at room temperature, the NiTBrPP forms a well-ordered close-packed molecular layer in

Dendroclimatology in Fennoscandia - from past accomplishments to future potential

Fennoscandia has a strong tradition in dendrochronology, and its large tracts of boreal forest make the region well suited for the development of tree-ring chronologies that extend back several thousands of years. Two of the world's longest continuous (most tree-ring chronologies are annually resolved) tree-ring width chronologies are found in northern Fennoscandia, with records from Tornetrask an

Body part terms in Kammu

This article is a study of words for body parts in the Mon-Khmer language Kammu. It contains one descriptive part, presenting some 200 thematically ordered entries of words related to the body, with belonging elucidation and illustrations. In a more theoretical and comparative part, the data are used to relate Kammu to a wider debate concerning the semantic domain of body parts. Cross-linguistic s

Inhibition of Galectins with Small Molecules

Evidence that the galectin family of proteins plays crucial roles in cancer, inflammation, and immunity has accumulated over the last decade. The galectins have consequently emerged as interesting drug targets. A majority of galectin functions occurs by means of cross-linking glycoproteins and by doing so controlling gly-coproteirl cellular localization and residence times. The glycoprotein cross-

On the Treatment of Finance – Specific Factors Within the OLI Paradigm

This article argues that the body of foreign direct investment (FDI) literature in general and the ownership, location, and internalization (OLI) paradigm in particular would be enriched if finance-specific factors are explicitly incorporated as drivers of FDI. We suggest that financial strategies involving factors such as debt/equity swaps or equity listings in foreign equity markets affect the f

Parental Grief and Prayer in the Middle Ages : Religious Coping in Swedish Miracle Stories

This article focuses on expressions of bereavement and religious coping in medieval miracle stories from Sweden. The stories come from the collections of St. Birgitta (Bridget) of Sweden, the Blessed Bishop Nicolaus Hermanni (Sw. Nils Hermansson) of Linköping and the Blessed Katarina of Vadstena, and were recorded in the fourteenth and fifteenth centuries. Catherine M. Sanders’s modern five stages