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Under global warming, flooding has become one of the most destructive natural disasters along the China–Pakistan Economic Corridor (CPEC), which significantly jeopardizes the construction and ongoing stability of the CPEC. The assessment of regional flood potential is, therefore, crucial for effective flood prevention and relief measures. In light of this, our study applied MIKE 11 hydrodynamic mo

BACKGROUND: Epicardial mapping is a powerful tool that has enabled us to gain insight into the electrical phenomena perpetuating atrial fibrillation and has guided the design of surgical and catheter-based therapeutic strategies. However, epicardial data are acquired during abnormal physiological conditions; the patients are anaesthetized, their chests opened, dislocating the heart and exposing it

Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr

There are over 100 different types of cancer, and each is classified based on the type of cell that is initially affected. If left untreated, cancer can result in serious health problems and eventually death. Recently the paradigm of cancer chemotherapy has evolved to use a combination approach, which involves the use of multiple drugs each of which targets an individual protein. Inhibition of hea

Domestication processes tend to release animals from natural selection and favour traits desired by humans, such as food-production and co-operative behaviour. A side effect of such selective breeding is the alteration of unintended traits. In this paper, we investigate how active selection for egg production in chickens has affected the visual system, in particular the optical sensitivity that re

Kamchatka is one of the world's most active volcanic regions and has hosted many explosive eruptions during the Holocene. These eruptions had the potential to disperse tephra over wide areas, forming time-synchronous markers wherever those tephras are found. Recent research in Kamchatka has begun to focus on the geochemical analysis of individual glass shards in order to characterise tephra layers

Objectives & Methods: Diseases of the human urinary tract represent common morbidities characterized by a high prevalence in the population of most westernized countries. The existeince of a significant number of affected patients and the recent increase in scientific attention has resulted in various experimental and clinical efforts in order to evaluate the mechanisms controlling the functio

Thylakoids isolated from tobacco were fragmented by sonication and the vesicles so obtained were separated by partitioning in aqueous polymer two-phase systems. By this procedure, grana vesicles were separated from stroma exposed membrane vesicles. The latter vesicles could be further fractionated by countercurrent distribution, with dextran-polyethylene glycol phase systems, and divided into two

Popular Abstract in Swedish Denna doktorsavhandling i Rättssociologi handlar om barns rättigheter och barnarbete i Paraguay. Problematiken kring barnarbete i Paraguay är central för avhandlingen och författaren har undersökt samt beskrivit de rättsliga ideal som är tänkta att upprätthålla och stärka det rättsliga skyddet för barns rättigheter. De rättsliga idealen kontrasteras sedemera mot den norThe present study is composed of eight chapters relating to children's rights and child labor activity in the Republic of Paraguay. The problem of child labor in Paraguay is central for this study and the legal ideals that are intended to uphold and strengthen the rights of the child are described and contrasted with the present normative reality in which the children work and live. The discrepanc

This chapter explains that the causation inquiry performed by the European Court of Human Rights for determining breach of positive obligations has to be understood in light of the normative structural considerations that underpin state responsibility under the European Convention on Human Rights (ECHR). In particular, the responsibility system is not shaped by the corrective justice rationale tha

INTRODUCTION: An increasing number of sub-Saharan African countries are implementing national health insurance schemes (NHISs) to support the aspiration of universal health coverage (UHC). A growing body of literature recognises the private sector role in improving NHIS equity in service access, public provider complementarity and overall member satisfaction. Zambia has implemented the NHIS since

This chapter explains that the causation inquiry performed by the European Court of Human Rights for determining breach of positive obligations has to be understood in light of the normative structural considerations that underpin state responsibility under the European Convention on Human Rights (ECHR). In particular, the responsibility system is not shaped by the corrective justice rationale tha

The rise of far-right anti-gender movements has become increasingly visible, particularly in Europe, with the surge of far-right actors in last elections. Additionally, we are witnessing the development of various global crises, including wars, genocide, and harshened migration policies in the Global North. This shift coalesces with a time when feminist, queer and anti-racist movements have gather

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous genetic heterogeneity of this disease group. However, the last decade has yielded a wealth of new knowledge on degenerative pathways and their diversity. Notably, a central role of cGMP-signalling has surfaced for photoreceptor cell death triggered by