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Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models

Popular science summary: Predictive model for unbound brain-to-plasma concentration ratio Blood-brain barrier (BBB) is a dynamic interface evolved to protect the brain from exposure to toxic xenobiotics and to maintain homeostasis. Distribution of drugs across BBB is critical for any drug discovery project. A drug designed for a target in brain has to pass through the BBB in sufficient concentr

Knowledge For Sustainable Development Conference 2022 Abstracts

Conference abstracts Knowledge for Sustainable Development – Lund University Research Conference 2 May 2022 | Sustainability Week in Lund 2022 Content Summary of research abstracts presented during the conference. 1. Theme I: Understanding and measuring processes in sustainable development 2. Theme II: Research for sustainability and change 3. Theme III: Implementation – obstacles, challenges, and

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/2022-04/Knowledge%20for%20Sustainable%20Development%20Conference%202022_Abstracts.pdf - 2026-05-15

Yrkesmässig fotografering med drönare och skyddet för enskildas personliga integritet

Drönare är obemannade luftfartyg som vanligtvis fjärrstyrs från marken. Från att ursprungligen ha brukats i militär verksamhet har drönare de senaste åren börjat spridas till civila näringsverksamheter, t.ex. inspektion av fastigheter. Genom HFD 2016 ref. 71 I fastställde Högsta förvaltningsdomstolen att kameror monterade på drönare är övervakningskameror, och därför är tillståndspliktiga enligt kDrones are unmanned aerial vehicles that are controlled from the ground. From having been used at first solely for military purposes, they have spread to civil businesses over the last few years, for example to help at property inspections. Through HFD 2016 ref. 71 I it was decided that cameras mounted on drones are considered as surveillance cameras and require permits according to the camera sur

The treatment costs of ADHD - A framework for future economic evaluations

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurobehavioral problems among both children and adults. Around 5% of the children and 3- 4% of the adults suffers from the condition in Sweden. In general, diagnosed children achieve poorer results on standardized tests, receive lower grades and are more prone to dropout of school. Adults tend to struggle with work-performa

What's Next in Sustainable Acoustic Materials?

Allteftersom företag har börjat att ompröva sättet de designar, tillverkar och avyttrar produkter inom ramarna för hållbar utveckling så har tillverkare av akustiska produkter varit långsamma ur startblocken. Majoriteten av akustiska produkter är fortfarande primärt sammansatta av nyråvara från petrokemiska resurser, vilka har en signifikant påverkan på miljön. Det är problematiskt ur både en miljAs industries have begun to rethink the way they design, make and dispose of products for the purpose of sustainable development, manufacturers of acoustic products have been slow off the mark. The majority of acoustic products are still made of primarily virgin material made from petrochemical resources, which have a significant impact on the environment. This is problematic from an environmental

The Most Delicate Subject : A History of Sex Education Films in Sweden

The aim of this dissertation is to present a history of sex education films in Sweden, from their beginnings until the late 1970s, relating the films to the changing historical context of the Swedish welfare society. Within this framework, the dissertation explores two main sets of questions. First, utilizing a contextual understanding of genre, the dissertation analyzes how the films were produce

HIV disease progression - Impact of HIV-1 intersubtype recombination and association with HIV-2 evolution

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are both causative agents of AIDS, with similar pathogenic characteristics. However, the rate of disease progression is highly variable both within and between HIV-1 and HIV 2, but the mechanisms involved in modulating the rate of disease progression remain poorly understood. Host genetics account for some of the variation within each

Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial

Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adj

Do lighting control and user interface design matter to occupant behaviour? The case of optimal lighting use in non-residential buildings

Popular Abstract in Swedish Att reducera energianvändningen för belysning i byggnader är viktigt för att uppnå målet att minska koldioxidutsläppen. Ett sätt att nå målet är om vi kan förändra människors beteende vilket kan ge en stor energibesparing. Feedback rörande energianvändning har ofta använts för att förändra beteende, men effektiviteten hos detta tillvägagångssätt är mer ifrågasatt för ap

SPECT Imaging using Pinhole Collimation : System Design and Simulation Studies for Pre-Clinical and Clinical Imaging

Nuklearmedicinsk bildtagning med hjälp av radiofarmaka är ett viktigt verktyg för att studera biologiska processer och humansjukdomar. Bildtagning sker ofta med en detektor i kombination med en kollimator. En typ av kollimering är pinnhålskollimering, där ett pinnhål i ett opakt material placeras mellan en källa och en detektor. Pinnhålet fyller samma funktion som en optisk lins då emitterade fotoThe focus of this dissertation is the use of pinhole collimation in Nuclear Medicine. A pinhole is a single aperture in an opaque material that is placed between the detector and source of interest, and photons must pass through the hole to reach the detector. The choices of pinhole parameters, e.g. the pinhole material and size of the opening, are closely linked to the performance of the detector

Comparative study of pheromone production and response in Swedish and Zimbabwean populations of turnip moth, Agrotis segetum

Analysis of female sex pheromone gland extracts of the turnip moth (or common cutworm), Agrotis segetum, from Zimbabwe revealed three compounds previously identified as sex pheromone components in the Swedish population, namely (Z)-5-decenyl acetate (Z5-10:OAc), (Z)-7-dodecenyl acetate (Z7- 12:OAc), and (Z)-9-tetradecenyl acetate (Z9-14:OAc). However, the proportions from the Zimbabwean population

Factors Affecting Rates of Change in Soil Bacterial Communities

Popular Abstract in Swedish Jorden i vår natur är en mycket komplex miljö som innehåller en mängd olika organismer. Bland dessa är bakterier och svampar av störst betydelse eftersom de står för en stor del av nedbrytningen av olika ämnen. Jordbakterierna utför t.ex. många av ämnesomvandlingarna av kväve, svavel och fosfor i marken. Nedbrytningen frigör näringsämnen som sedan kan utnyttjas av växteThe soil bacterial community is under the constant influence of its environment. Changing any of the factors affecting the bacterial community will induce a selection pressure which, with time, will change the community. In this work the effect of changing the temperature or pH on the soil bacterial community was studied. Measurements using the [3H]-thymidine incorporation technique showed that th

The Physical Foundation of the Patterning of Physical Action Verbs : A Study of Chinese Verbs

Popular Abstract in Swedish Den fysiska grunden för fysiska aktionsverbThis work is a study of verbal semantics with a focus on the discussion and illustration of the role of body parts and the semantic incorporation into verbal roots of the actions that involve various body parts. Following a general discussion of the basic issues of language construction and human body actions with the image schemas of force-dynamics presented in line with the framework of cognitiv

The effects of temperature on avian physiology, behavior and development

Popular Abstract in Swedish Omgivningens temperatur är kanske en av de faktorer som i allra störst utsträckning påverkar djur och deras livsmiljö. Detta bottnar givetvis till stor del i temperaturens effekt på naturen. Betänk till exempel årstidsväxlingarna; att vintern blir till vår, och att hösten (i samband med de första snöfallen) allt mer skrider mot ännu en kall och vit vinter bestäms och reTemperature is a property of profound matter in all aspects of animal life, affecting both individual energy budgets and the environments in which animals reside. Thus, a proper understanding of the effects of temperature variation is instrumental in understanding not only animal form and function, but also the structure and dynamics of wild populations. Accordingly, the aims of this thesis were t