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Handeln med piratkopierade och varumärkesförfalskade varor, det vill säga varor som gör intrång i immateriella rättigheter, har ökat kraftigt. Utvecklingen har gått från småskalig verksamhet till en global industri. De intrångsgörande varorna orsakar omfattande skador för rättighetshavare, bland annat genom förlorade intäkter och dåligt rykte. Vidare kan varorna medföra risker för konsumenternas sTrade with pirated and counterfeited goods has increased considerably. The development has transited from small scale production towards becoming a global industry. Infringed goods cause large damage for right holders, not only do they lose revenue, but also the companies’ image and market value is under fire. Furthermore, infringing goods cause damage not only to right holders, but also affect co

Type-2 diabetes (T2D) worsens stroke recovery, amplifying post-stroke disabilities. Currently, there are no therapies targeting this important clinical problem. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are potent anti-diabetic drugs that also efficiently reduce cardiovascular death and heart failure. In addition, SGLT2i facilitate several processes implicated in stroke recovery. However,

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has

Background and purposeDiagnostic information about cell density variations and microscopic tissue anisotropy can be gained from tensor-valued diffusion magnetic resonance imaging (MRI). These properties of tissue microstructure have the potential to become novel imaging biomarkers for radiotherapy response. However, tensor-valued diffusion encoding is more demanding than conventional encoding, and

Understanding and manipulating micelle morphology are key to exploiting surfactants in various applications. Recent studies have shown surfactant self-assembly in a variety of Deep Eutectic Solvents (DESs) where both the nature of surfactants and the interaction of the surfactant molecule with the solvent components influence the size, shape, and morphology of the micelles formed. So far, micelle

The high polymorphism of Major Histocompatibility Complex (MHC) genes is generally considered to be a result of pathogen-mediated balancing selection. Such selection may operate in the form of heterozygote advantage, and/or through specific MHC allele–pathogen interactions. Specific MHC allele–pathogen interactions may promote polymorphism via negative frequency-dependent selection (NFDS), or sele

Background and Aims: There are increasing reports on case series on spontaneous isolated mesenteric artery dissection, that is, dissections of the superior mesenteric artery and celiac artery, mainly due to improved diagnostic capacity of high-resolution computed tomography angiography performed around the clock. A few case–control studies are now available, while randomized controlled trials are

Although, today, jus cogens is a recognized element of international law and international legal discourse alike, many issues of vital importance to a well-functioning jus cogens regime remain unsettled. The current debate centers on the following six questions: (1) What is the source of jus cogens obligations? (2) What is the role of consent in the creation and modification of jus cogens norms? (

Swedish biomass production potential could be increased significantly if new production methods, such as optimised fertilisation, were to be used. Optimised fertilisation on 25% of Swedish forest land and the use of stem wood could almost double the biomass potential from forestry compared with no fertilisation, as both logging residues and large quantities of excess stem wood not needed for indus