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The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic facto

This dissertation deals with the transferability of an evidence-based treatment method from one cultural context to another, with Multisystemic Therapy (MST) in Sweden as an example. The primary research question is whether the evidence-based treatment intervention MST can be transferred from the US to Sweden with retained treatment effects. This thesis is organized around four separate but interr

Deep sternal wound infection (DSWI) following cardiothoracic surgery is a rare but potentially life-threatening complication with high morbidity and mortality. DSWI is associated with a significant increase in the length of hospital stay and the cost of hospitalization. The socioeconomic impact of DSWI is considerable. Conventional treatment includes reexploration, surgical debridement, mediastin

Colorectal cancer (CRC) is the third most common cancer worldwide with more than 700,000 deaths every year. Prognosis mostly depends on disease stage at diagnosis, however, outcome may vary considerably even within the same stage. Thus, there is a great need for new prognostic biomarkers to better identify patients with a high risk of developing metastases and select right patients for adjuvant tr

Background: The production of bioethanol from lignocellulose hydrolysates requires a robust, D-xylose-fermenting and inhibitor-tolerant microorganism as catalyst. The purpose of the present work was to develop such a strain from a prime industrial yeast strain, Ethanol Red, used for bioethanol production. Results: An expression cassette containing 13 genes including Clostridium phytofermentans Xyl

Arctic soils hold large amounts of nutrients in the weatherable minerals and the soil organic matter, which slowly decompose. The decomposition processes release nutrients to the plant-available nutrient pool as well as greenhouse gases to the atmosphere. Changes in climatic conditions, for example, changes in the distribution of snow, water balance and the length of the growing season, are likely

Popular Abstract in Swedish Studien behandlar den sydsvenske bonadsmålaren Johannes Nilssons måleri. Denne produktive målare levde och verkade i Breareds socken i södra Halland 1757­1827. En analys av hans bonader visar att han i många stycken frångick sina föregångares traditionella, imiterande framställning och begränsade motivkrets. Den övergripande frågan i avhandlingen är: varför målade JohanThe aim of this dissertation is to find relationships between folk art, an artist's personal life and influential factors originating in the context. Christmas wall hangings by the peasant painter Johannes Nilsson (1757­1827) are the focus of the study. The fact that he had a special approach to the painting tradition raises two questions: Why did he paint the way he did? How can his hangings be i

Popular Abstract in Swedish Huvud- hals cancer Studier kring betydelsen av kärltäthet, svar på strålbehandling och tumörmetabolism, undersökt med positron emissions tomografi ( PET) Bakgrund Cancer i huvud-hals området är ovanligt i Sverige och utgör c:a 2,5% av alla nya cancerfall (40 000) per år. Beteckningen är ett samlingsnamn för tumörer med sinsemellan skilda egenskaper, uppkomna från i förTreatment options of head and neck squamous cell carcinoma (HNSCC) usually include combinations of radiotherapy and surgery, and in some cases addition of chemotherapy. In locally advanced cases cure rates are low. Current prognostic factors cannot foresee the outcome for the individual patient. There is consequently a need for reliable prognostic and predictive factors. Through identification of

Popular Abstract in Swedish Därför får man sockersjuka (Felix Mulder, 6 år): ”Det är inte bra att äta för mycket socker. Socker är vasst och skär sönder blodkropparna. Då kan man inte göra insulin och man blir sjuk.” Islet amyloid polypeptide (förkortat: IAPP) är ett medelstort äggviteämne - peptid - som upptäcktes 1986 av Per Westermark i Uppsala. Denna upptäckt har en intressant bakgrund. Det h

Popular Abstract in Swedish Den vertikala fördelningen av näringsupptaget hos gran (Picea abies (L.) Karst.), bok (Fagus sylvatica L.) och skogsek (Quercus robur L.) och har undersökts i södra Skandinavien. Två olika metoder har används. Med den första metoden uppskattades trädets näsringsupptag på olika markdjup genom att bestämma fördelningen av rötterna och det externa ectomycorrhizamycelet (EE

General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data fro

Popular Abstract in Swedish Homocystein är en aminosyra som bildas genom nedbrytning av aminosyran metionin, som tillförs kroppen via födan. Förhöjda blodnivåer av homocystein kan orsakas av medfödda enzymrubbningar, brist på vitaminerna folsyra och B12, och vissa sjukdomar, t ex njursvikt. Medfödd enzymbrist kan ge mycket höga blodnivåer av homocystein, vilket bland annat leder till kärlskada och

Infertility, defined as the inability to conceive after one year of unprotected regular intercourse, affects up to 15% of all couples of reproductive age. The infertility can originate from female, male or both partners. In up to 50% of the affected couples, a male factor is the cause of infertility. Semen analysis is the cornerstone of male infertility assessment and an abnormal result often trig

Collagen-induced arthritis (CIA) is one of the most commonly used animal models for Rheumatoid arthritis (RA). CIA is induced in susceptible mouse strains after immunization with heterologous type II collagen (CII). In mice of the H-2q haplotype rat CII (rCII) is used whereas in mice of the H-2r haplotype bovine CII is utilized. The broad objective of this thesis was to gain an understanding of th

Background: Both aging and Alzheimer's disease (AD) affect brain networks, with early disruptions occurring in regions involved in episodic memory. Few studies have, however, focused on distinguishing region-specific effects of AD-biomarker negative “normal” aging and early amyloid- and tau pathology on functional connectivity. Further, longitudinal studies combining imaging, biomarkers, and cogni