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Reduction of the anticancer trans platinum(IV) prodrug JM335 by thiols in a moderately alkaline aqueous perchlorate medium is quite rapid and yields trans-[Pt(OH)2(c-C6H11NH2)(NH3)] as the reaction product. The mechanism of reduction involves reductive attack by thiol or thiolate on one of the mutually trans chloride ligands, leading to the formation of a chloride-bridged activated complex.The red

SynopsisOn the basis of kinetic studies of the manganese-catalyzed autoxidation of sulfite and thermodynamic data for iron−manganese redox processes and manganese(II) and -(III) protolysis equilibria, the catalytically active species in the autoxidation is concluded to be a mixed-valence oxo-bridged manganese(II,III) complex. Iron−manganese synergism and triggering of the chain reaction by small c

SynopsisVarious protolytic species of thiols RSH (thioglycolic acid, l-cysteine, dl-penicillamine, and glutathione) in rapid equilibria with each other reduce trans-[Pt(CN)4Cl2]2- in parallel, halide-bridged electron transfer reactions. A linear Brønsted correlation between the reactivity of the thiolate anions RS- and their basicity is observed. The mechanism derived might be used as a model for

Background: Current guidelines recommend androgen deprivation therapy only for men with very high-risk prostate cancer (PCa), but there is little evidence to support this stance. Objective: To investigate the association between radical local treatment and mortality in men with very high-risk PCa. Design, setting, and participants: Semiecologic study of men aged <80 yr within the Prostate Cancer d

The handling of biochemically functionalised beads or particles is becoming increasingly important in µTAS. Bead-based analysis of e.g. proteins can be made sensitive due to the large active surface area and flexible by chemical design of the bead surface. We have developed a microfluidic device utilising an array of integrated and individually controlled ultrasonic microtransducers for particle t

We present the results of 3D high-resolution calculations of the last inspiral stages and the final coalescence of neutron star binary systems. The equations of hydrodynamics are solved using the smoothed particle hydrodynamics method with up to 106 particles. Using Newtonian gravity, but adding the forces emerging from the emission of gravitational waves, we focus on the impact of microphysics on

Popular Abstract in Swedish Stora framsteg har gjort det möjligt att, med dagens teknik, inte bara visualisera enskilda atomer, utan även utföra olika typer av operationer och manipulationer på atomskalan med stor precision rent experimentellt. Detta har möjliggjort tillverkning av komplexa nanostrukturer genom montering av komponenter av nanostorlek till större sammansatta system, vilket i sin tuNanowires constitute one of the fundamental building blocks in assembled nanodevices. Due to the high surface to volume ratio, the fraction of surface atoms is not negligible for nanosized elements. Because of the reduced coordination of surface atoms, the physical properties deviate from those of the bulk, which influences the overall physical properties of nanostructures. Consequently, this prov

The aim was to elucidate the cardiovascular response associated with breath-hold diving, especially the effects of temperature in its elicitation and the effects of different types of training on the human diving response (DR) and breath-holding time (BHT), and to evaluate the human DR in a mammalian perspective. A model for simulated diving by apnea and facial immersion in cold water was develope

Heat transfer in gas turbine related applications is investigated by steady state liquid crystal thermography (LCT) in this thesis. The work presented includes outlet guide vane heat transfer and gas turbine internal cooling.The heat transfer on the outlet guide vane (OGV) surface and its endwall region is investigated experimentally in a linear cascade test facility. The inlet flow angle is varie

The delineation and characterization of fracturing is important in the successful exploitation of many hydrocarbon reservoirs. Such fracturing often occurs in preferentially aligned sets; if the fractures are of subseismic scale, this may result in seismic anisotropy. Thus, measurements of anisotropy from seismic data may be used to delineate fracture patterns and investigate their properties. Her