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The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases. They are downstream effectors of the Ras/ERK/MAPK signaling cascade. ERK1/2 activation directly results in the phosphorylation of RSKs, which further, through interaction with a variety of different downstream substrates, activate various signaling events. In this context, they have been shown t

The purpose of this study was to understand the type of disciplining and normalizing that includes in the two measures the Development Guarantee and the Employment Guarantee for youth. This study is based on a qualitative content analysis with inspiration from hermeneutics where discipline and normalizing represent the theoretical starting points. Five assessments from governmental agencies regard

Stadsmiljö skiljer sig från det ursprungliga landskapet, som till stor del har lämnats orörd av människan. När mer och mer mark används till att bygga städer eller för att odla mat kan det skapa problem för pollinatörer, då de är anpassade till den naturliga miljön. Pollinatörerna kan däremot ofta överleva inuti städer i parker, rabatter och trädgårdar. Det är viktigt att bevara pollinatörer, då o

A qualitative case study set in Colombo, Sri Lanka focusing on women’s representation in local governance. The essay follows the aftermath of the country’s newly implemented electoral reform, which since 2018 resulted in a mixed- member-proportional electoral system with a gender quota. Throughout an extensive interview process with local politicians and experts alike, six barriers were identified

In January 1990 an expert group was set up by DP2 of TC2, CEC to define the research and development work needed to be undertaken within the community to achieve a robust solution with respect to reaction-to-fire material classification. The expert group delivered in December 1990 its proposal for a 5-year research and development program. But a system of harmonised European fire test methods and

The cholinergic hypothesis of geriatric memory dysfunction suggests that the learning and memory deficits representing the cardinal symptoms of dementia in the aged and in patients suffering from Alzheimer's disease may be attributable to a decline in the function of the cholinergic projection systems of the basal forebrain. Although many studies have addressed the issue of a causal relationship b

The Expansion of Higher Education in the Swedish the Welfare State and the Reconfiguration of its Professional Workforce Gunnar Olofsson The rapid expansion of the Swedish university sector has channelled many students into study programs that lead to employment in new kinds of jobs, occupations and professional groups. There are three main reasons why more and more occupations get their training

Sweden is a country that traditionally respects the freedom of association and the large number of existing trade unions confirms this statement.On the other hand, however, the Swedish trade union system is structured in a way that eliminates almost every sort of competition between different organizations. In fact, for every sector of the economy there is approximately one union for blue collars

Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the

Abstract in French Beaucoup d’hommes et de femmes aymara affirment que le savoir humain, transmis par la langue, n’est qu’un pur ‘siwsawi’, i.e. des paroles, des opinions, des points de vue, des jugements d’individus particuliers. Ainsi, il s’agit d’un savoir particulier ; c’est une connaissance concernant l’opinion de certaines personnes, rien de plus. Ceci est, de manière significative, différenMany Aymara men and women claim that human knowledge as transmitted through language is pure ‘siwsawi’, i.e. talk, opinions, views and judgments of particular individuals. As such it is knowledge of a particular kind; it is knowledge concerning the opinions of other humans, nothing else. It is thereby significantly different from the non-linguistic, experiential knowledge that is lived-through and

T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical

Cellular Neural Networks are characterized by simplicity of operation. The network consists of a large number of nonlinear processing units; called cells; that are equally spread in the space. Each cell has a simple function (sequence of multiply-add followed by a single discrimination) that takes an element of a topographic map and then interacts with all cells within a specified sphere of intere

The access to safe and clean drinking water is a major concern throughout the world. Surface water has become the most common source for raw water, when large quantities of groundwater often are inaccessible, and as surface water requires more treatment, simple, cheap and efficient process methods are necessary. Turbidity removal is essential for treatment of surface water and is often carried out

For a successful project of urban wind power requires wind as well as attachments, sound level and the requirements and regulations should be taken under consideration. But a lot of experience is still lacking and many projects fail therefore. This report covers the aspects described above and a summary of experiences and knowledge gaps have been made with the aim of facilitating the planning phas

This thesis deals with students' constructions of mathematical knowledge in the case of fractions from a radical constructivist perspective. Fractions are the first more abstracted mathematics met by students. Even if they have a rich experience of sharing and partitioning things in their everyday life dealing with fractions often give rise to difficulties in school. The thesis consists of two p